Results 11 to 20 of about 128,436 (385)
Journal of Biological Chemistry, 1986 Diacylglycerol kinase is though to play a central role in the metabolism of diacylglycerol second messengers in agonist-stimulated cells. A series of diacylglycerol analogs were tested for their ability to act as substrates or inhibitors of diacylglycerol kinase with the goal of determining the substrate specificity of the enzyme, and of discovering ...
Barry R. Ganong +2 more
openaire +4 more sources
Evidence for a compartmentation of brain microsomal diacylglycerol
Journal of Lipid Research, 1982 Phosphatidylcholine synthesis from CDP-[methyl-14C]choline and membrane-bound diacyl-[U-14C]-sn-glycerol, formed through the glycerol phosphate pathway, has been examined in vitro in rat brain microsomes.
L Binaglia +3 more
doaj +2 more sources
Diacylglycerol as messenger [PDF]
Nature, 1990 Ole H. Petersen, Claes B. Wollheim
openaire +3 more sources
The role of diacylglycerol in the exocytosis of the sperm acrosome. Studies using diacylglycerol lipase and diacylglycerol kinase inhibitors and exogenous diacylglycerols [PDF]
Biochemical Journal, 1992 When ram spermatozoa were treated with Ca2+ and the ionophore A23187 to induce acrosomal exocytosis, a rise in diacylglycerol (DAG) mass was observed, concomitant with a rapid breakdown of [32P]P1-labelled phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 4-phosphate and a rise in [32P]Pi-labelled phosphatidate. Inclusion of the DAG lipase
R A P Harrison, E R S Roldan
openaire +3 more sources
Diacylglycerol kinase η1 is a high affinity isozyme for diacylglycerol [PDF]
FEBS Letters, 2015 Diacylglycerol kinase (DGK) η plays important roles in various patho‐physiological events such as oncogenesis. In this study, we performed an enzymological characterization of DGKη splice variant 1 (DGKη1). The K m value for diacylglycerol was 0.14 mol%.
Hiromichi Sakai +3 more
openaire +3 more sources
Foods, 2022 Diacylglycerols (DAGs) display huge application prospectives in food industries. Therefore, new strategies to produce diacylglycerides are needed. Malassezia globose lipase (SMG1) could be used to synthesize DAGs. However, the poor thermostability of SMG1 seriously hampers its application.
Lilang Li +4 more
openaire +3 more sources
Insulin Action on Polyunsaturated Phosphatidic Acid Formation in Rat Brain: An “In Vitro” Model with Synaptic Endings from Cerebral Cortex and Hippocampus [PDF]
, 2009 The highly efficient formation of phosphatidic acid from exogenous 1-stearoyl-2-arachidonoyl-sn-glycerol (SAG) in rat brain synaptic nerve endings (synaptosomes) from cerebral cortex and hippocampus is reported.
Giusto, Norma Maria +2 more
core +1 more source
Journal of Lipid Research, 2019 Phosphatidic acid (PA) phosphatase is an evolutionarily conserved enzyme that plays a major role in lipid homeostasis by controlling the cellular levels of its substrate, PA, and its product, diacylglycerol.
George M. Carman, Gil-Soo Han
doaj +1 more source
Cell Reports, 2017 Hepatic lipid accumulation has been implicated in the development of insulin resistance, but translational evidence in humans is limited. We investigated the relationship between liver fat and tissue-specific insulin sensitivity in 133 obese subjects ...
Kasper W. ter Horst +13 more
doaj +1 more source
Induced hyperlipaemia and immune challenge in locusts [PDF]
, 2004 Injections of immunogens, such as β-1,3-glucan or lipopolysaccharide (LPS), bring about a marked hyperlipaemia with associated changes in lipophorins and apolipophorin-III in the haemolymph of Locusta migratoria.
Ashida +39 more
core +1 more source