Results 21 to 30 of about 59,986 (162)

Liver-specific loss of lipin-1-mediated phosphatidic acid phosphatase activity does not mitigate intrahepatic TG accumulation in mice

Journal of Lipid Research, 2015
Lipin proteins (lipin 1, 2, and 3) regulate glycerolipid homeostasis by acting as phosphatidic acid phosphohydrolase (PAP) enzymes in the TG synthesis pathway and by regulating DNA-bound transcription factors to control gene transcription.
George G. Schweitzer, Zhouji Chen, Connie Gan, Kyle S. McCommis, Nisreen Soufi, Roman Chrast, Mayurranjan S. Mitra, Kui Yang, Richard W. Gross, Brian N. Finck   +9 more
doaj   +1 more source

Hepatic insulin sensitivity is improved in high‐fat diet‐fed Park2 knockout mice in association with increased hepatic AMPK activation and reduced steatosis

Physiological Reports, 2019
Park2 is an E3 ubiquitin ligase known for its role in mitochondrial quality control via the mitophagy pathway. Park2 KO mice are protected from diet‐induced obesity and hepatic insulin sensitivity is improved in high‐fat diet (HFD)‐fed Park2 KO mice even
Lia R. Edmunds, Brydie R. Huckestein, Mario Kahn, Dongyan Zhang, Yanxia Chu, Yingze Zhang, Stacy G. Wendell, Gerald I. Shulman, Michael J. Jurczak   +8 more
doaj   +1 more source

Sesame oil inhibits the formation of glycidyl ester during deodorization

International Journal of Food Properties, 2021
Glycidyl ester (GE) has attracted worldwide attention due to its potential harm to human health. The GE in edible oil forms during the deodorization process of the oil refining, where antioxidants are used to inhibit its formation.
Lipeng Han, Jiahui Li, Shujie Wang, Weiwei Cheng, Lukai Ma, Guoqin Liu, Dongxue Han, Li Niu   +7 more
doaj   +1 more source

Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance

Cell Reports, 2017
Serine hydrolases are a large family of multifunctional enzymes known to influence obesity. Here, we performed activity-based protein profiling to assess the functional level of serine hydrolases in liver biopsies from lean and obese humans in order to ...
Maxwell A. Ruby, Julie Massart, Devon M. Hunerdosse, Milena Schönke, Jorge C. Correia, Sharon M. Louie, Jorge L. Ruas, Erik Näslund, Daniel K. Nomura, Juleen R. Zierath   +9 more
doaj   +1 more source

Immobilized Lipase in the Synthesis of High Purity Medium Chain Diacylglycerols Using a Bubble Column Reactor: Characterization and Application

Frontiers in Bioengineering and Biotechnology, 2020
Novozym® 435, an immobilized lipase from Candida antarctica B. (CALB), was used as a biocatalyst for the synthesis of high purity medium chain diacylglycerol (MCD) in a bubble column reactor.
Jiazi Chen, Wan Jun Lee, Chaoying Qiu, Shaolin Wang, Guanghui Li, Yong Wang   +5 more
doaj   +1 more source

Changes in Plasma Bioactive Lipids and Inflammatory Markers during a Half-Marathon in Trained Athletes

Applied Sciences, 2021
Background: Exercise may affect lipid profile which in turn is related to inflammation, although changes of ceramides, diacylglycerols-DAG and sphingomyelin-SM and their relationship with inflammatory parameters following a half-marathon have never been ...
Melania Gaggini, Cristina Vassalle, Fabrizia Carli, Maristella Maltinti, Laura Sabatino, Emma Buzzigoli, Francesca Mastorci, Francesco Sbrana, Amalia Gastaldelli, Alessandro Pingitore   +9 more
doaj   +1 more source

Regulation of Signaling and Metabolism by Lipin-mediated Phosphatidic Acid Phosphohydrolase Activity

Biomolecules, 2020
Phosphatidic acid (PA) is a glycerophospholipid intermediate in the triglyceride synthesis pathway that has incredibly important structural functions as a component of cell membranes and dynamic effects on intracellular and intercellular signaling ...
Andrew J. Lutkewitte, Brian N. Finck
doaj   +1 more source

Onset of Senescence and Steatosis in Hepatocytes as a Consequence of a Shift in the Diacylglycerol/Ceramide Balance at the Plasma Membrane

Cells, 2021
Ceramide and diacylglycerol (DAG) are bioactive lipids and mediate many cellular signaling pathways. Sphingomyelin synthase (SMS) is the single metabolic link between the two, while SMS2 is the only SMS form located at the plasma membrane. SMS2 functions
Gergana Deevska, Patrick P. Dotson, Mihail Mitov, D. Allan Butterfield, Mariana Nikolova-Karakashian   +4 more
doaj   +1 more source

The MprF homolog LysX synthesizes lysyl-diacylglycerol contributing to antibiotic resistance and virulence

Microbiology Spectrum, 2023
Lysyl-diacylglycerol (Lys-DAG) was identified three decades ago in Mycobacterium phlei, but the biosynthetic pathway and function of this aminoacylated lipid have since remained uncharacterized.
Cameron P. Gill, Christopher Phan, Vivien Platt, Danielle Worrell, Thomas Andl, Hervé Roy   +5 more
doaj   +1 more source

Lipídeos na nutrição de cães e gatos: metabolismo, fontes e uso em dietas práticas e terapêuticas Lipids in dogs and cats nutrition: metabolism, sources and application in practical and therapeutic diets

Revista Brasileira de Zootecnia, 2009
A partir do desenvolvimento de métodos mais precisos para a avaliação de lipídeos, diversos compostos têm sido descobertos e estudados como forma de enriquecer e melhorar dietas para atender às necessidades dos animais.
Luciano Trevizan, Alexandre de Mello Kessler   +1 more
doaj   +1 more source