Results 21 to 30 of about 73,981 (291)

Monogalactosyl Diacylglycerol Synthase 3 (OsMGD3) affects phosphate utilization and acquisition in rice

, 2022
Galactolipids are essential for compensating for the loss of phospholipids by "membrane lipid remodeling" in plants under phosphorus (P) deficiency. Monogalactosyl diacylglycerol (MGDG) synthases catalyze the synthesis of MGDG which is further converted ...
Singh, S., Panchal, P., Giri, J., Bhatia, C., Eastmond, P. J., Verma, L., Bhadouria, J., Bhunia, R.   +7 more
core   +1 more source

Perilipin 3 promotes the formation of membrane domains enriched in diacylglycerol and lipid droplet biogenesis proteins

Frontiers in Cell and Developmental Biology, 2023
Lipid droplets (LDs) serve as intracellular stores of energy-rich neutral lipids. LDs form at discrete sites in the endoplasmic reticulum (ER) and they remain closely associated with the ER during lipogenic growth and lipolytic consumption.
Rasha Khaddaj, Jiri Stribny, Stéphanie Cottier, Roger Schneiter   +3 more
doaj   +1 more source

Diverse antidepressants increase CDP-diacylglycerol production and phosphatidylinositide resynthesis in depression-relevant regions of the rat brain

BMC Neuroscience, 2008
Background Major depression is a serious mood disorder affecting millions of adults and children worldwide. While the etiopathology of depression remains obscure, antidepressant medications increase synaptic levels of monoamine neurotransmitters in brain
Undieh Ashiwel S, Vongtau Habiba OU, Tyeryar Kimberly R   +2 more
doaj   +1 more source

The essential roles of cytidine diphosphate-diacylglycerol synthase in bloodstream form Trypanosoma brucei [PDF]

, 2014
Funded by Wellcome Trust: Senior Research Fellowship, Grant Number: 067441 and Wellcome Trust, Grant Numbers: 082596, 093228.Lipid metabolism in Trypanosoma brucei, the causative agent of African sleeping sickness, differs from its human host in several ...
Lilley, Alison C., Smith, Terry K., Smith, Terry K, Young, Simon, Stark, Michael J. R., Lilley, Alison Catherine, Major, Louise Laura, Major, Louise   +7 more
core   +1 more source

A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters

Journal of Lipid Research, 2005
Acyl-CoA-dependent O-acyltransferases catalyze reactions in which fatty acyl-CoAs are joined to acyl acceptors containing free hydroxyl groups to produce neutral lipids.
Chi-Liang Eric Yen, Charles H. Brown, IV, Mara Monetti, Robert V. Farese, Jr.   +3 more
doaj   +1 more source

Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans

Cell Reports, 2017
Hepatic lipid accumulation has been implicated in the development of insulin resistance, but translational evidence in humans is limited. We investigated the relationship between liver fat and tissue-specific insulin sensitivity in 133 obese subjects ...
Kasper W. ter Horst, Pim W. Gilijamse, Ruth I. Versteeg, Mariette T. Ackermans, Aart J. Nederveen, Susanne E. la Fleur, Johannes A. Romijn, Max Nieuwdorp, Dongyan Zhang, Varman T. Samuel, Daniel F. Vatner, Kitt F. Petersen, Gerald I. Shulman, Mireille J. Serlie   +13 more
doaj   +1 more source

Inhibition of native TRPC6 channel activity by phosphatidylinositol 4,5-bisphosphate in mesenteric artery myocytes [PDF]

, 2008
The present work investigates the effect of phosphatidylinositol-4,5-bisphosphate (PIP2) on native TRPC6 channel activity in freshly dispersed rabbit mesenteric artery myocytes using patch clamp recording and co-immunoprecipitation methods.
Saleh, Sohag N., Albert, Anthony P., Large, William A., Large, WA, Saleh, SN, Albert, AP   +5 more
core   +1 more source

Fat-regulating phosphatidic acid phosphatase: a review of its roles and regulation in lipid homeostasis

Journal of Lipid Research, 2019
Phosphatidic acid (PA) phosphatase is an evolutionarily conserved enzyme that plays a major role in lipid homeostasis by controlling the cellular levels of its substrate, PA, and its product, diacylglycerol.
George M. Carman, Gil-Soo Han
doaj   +1 more source

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez   +22 more
wiley   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source