Results 41 to 50 of about 73,981 (291)

Effects of Fish Oil and Grape Seed Extract Combination on Hepatic Endogenous Antioxidants and Bioactive Lipids in Diet-Induced Early Stages of Insulin Resistance in Rats

Marine Drugs, 2020
Diacylglycerols (DAG) and ceramides have been suggested as early predictors of insulin resistance. This study was aimed to examine the combined effects of fish oil (FO) and grape seed extract (GSE) on hepatic endogenous antioxidants, DAG and ceramides in
Núria Taltavull, Bernat Miralles-Pérez, Maria Rosa Nogués, Sara Ramos-Romero, Lucía Méndez, Isabel Medina, Josep Lluís Torres, Marta Romeu   +7 more
doaj   +1 more source

Diacylglycerol hydrolysis in rat liver lysosomes [PDF]

, 1986
The matrix of rat liver lysosomes exhibits high hydrolytic activity towards 1,2-diacylglycerol with an optimum at pH 4.0. The lipolytic reaction follows Michaelis-Menten kinetics (apparent Vmax 470 nmol hydrolysedmin per mg protein; apparent Km71 μM 1,2 ...
Kunze, Hans, Bernd-Michael Löffler, Bernd Hesse, Löffler, Bernd-Michael, Hesse, Bernd, Hans Kunze   +5 more
core   +1 more source

A New Targeted Lipidomics Approach Reveals Lipid Droplets in Liver, Muscle and Heart as a Repository for Diacylglycerol and Ceramide Species in Non-Alcoholic Fatty Liver

Cells, 2019
Obesity is frequently associated with excessive accumulation of lipids in ectopic tissue and presents a major risk factor for type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD). Diacylglycerols (DAGs) and ceramides (CERs) were identified
Christina Preuss, Tomas Jelenik, Kálmán Bódis, Karsten Müssig, Volker Burkart, Julia Szendroedi, Michael Roden, Daniel F. Markgraf   +7 more
doaj   +1 more source

Lipid activation of protein kinases

Journal of Lipid Research, 2009
Lipids acutely control the amplitude, duration, and subcellular location of signaling by lipid second messenger-responsive kinases. Typically, this activation is controlled by membrane-targeting modules that allosterically control the function of kinase ...
Alexandra C. Newton
doaj   +1 more source

Liver-specific loss of lipin-1-mediated phosphatidic acid phosphatase activity does not mitigate intrahepatic TG accumulation in mice

Journal of Lipid Research, 2015
Lipin proteins (lipin 1, 2, and 3) regulate glycerolipid homeostasis by acting as phosphatidic acid phosphohydrolase (PAP) enzymes in the TG synthesis pathway and by regulating DNA-bound transcription factors to control gene transcription.
George G. Schweitzer, Zhouji Chen, Connie Gan, Kyle S. McCommis, Nisreen Soufi, Roman Chrast, Mayurranjan S. Mitra, Kui Yang, Richard W. Gross, Brian N. Finck   +9 more
doaj   +1 more source

Hepatic insulin sensitivity is improved in high‐fat diet‐fed Park2 knockout mice in association with increased hepatic AMPK activation and reduced steatosis

Physiological Reports, 2019
Park2 is an E3 ubiquitin ligase known for its role in mitochondrial quality control via the mitophagy pathway. Park2 KO mice are protected from diet‐induced obesity and hepatic insulin sensitivity is improved in high‐fat diet (HFD)‐fed Park2 KO mice even
Lia R. Edmunds, Brydie R. Huckestein, Mario Kahn, Dongyan Zhang, Yanxia Chu, Yingze Zhang, Stacy G. Wendell, Gerald I. Shulman, Michael J. Jurczak   +8 more
doaj   +1 more source

Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance

Cell Reports, 2017
Serine hydrolases are a large family of multifunctional enzymes known to influence obesity. Here, we performed activity-based protein profiling to assess the functional level of serine hydrolases in liver biopsies from lean and obese humans in order to ...
Maxwell A. Ruby, Julie Massart, Devon M. Hunerdosse, Milena Schönke, Jorge C. Correia, Sharon M. Louie, Jorge L. Ruas, Erik Näslund, Daniel K. Nomura, Juleen R. Zierath   +9 more
doaj   +1 more source

Sesame oil inhibits the formation of glycidyl ester during deodorization

International Journal of Food Properties, 2021
Glycidyl ester (GE) has attracted worldwide attention due to its potential harm to human health. The GE in edible oil forms during the deodorization process of the oil refining, where antioxidants are used to inhibit its formation.
Lipeng Han, Jiahui Li, Shujie Wang, Weiwei Cheng, Lukai Ma, Guoqin Liu, Dongxue Han, Li Niu   +7 more
doaj   +1 more source

Molecular analysis of a novel Drosophila diacylglycerol kinase, DGKϵ [PDF]

, 2001
Diacylglycerol kinase plays a central role in the metabolism of diacylglycerol by converting diacylglycerol into phosphatidic acid thus initiating resynthesis of phosphatidylinositols.
Birchler, James A, Frolov, Maxim V, Maxim V Frolov, James A Birchler, Benevolenskaya, Elizaveta V, Elizaveta V Benevolenskaya   +5 more
core   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source