Results 21 to 30 of about 128,436 (385)

Insights into Activation Mechanisms of Store-Operated TRPC1 Channels in Vascular Smooth Muscle. [PDF]

, 2020
In vascular smooth muscle cells (VMSCs), the stimulation of store-operated channels (SOCs) mediate Ca2+ influx pathways which regulate important cellular functions including contraction, proliferation, migration, and growth that are associated with the ...
Albert, AP, Baudel, MASM-A, Large, WA, Shi, J   +3 more
core   +1 more source

Acid sphingomyelinase activity is regulated by membrane lipids and facilitates cholesterol transfer by NPC2[S]

Journal of Lipid Research, 2014
During endocytosis, membrane components move to intraluminal vesicles of the endolysosomal compartment for digestion. At the late endosomes, cholesterol is sorted out mainly by two sterol-binding proteins, Niemann-Pick protein type C (NPC)1 and NPC2.
Vincent O. Oninla, Bernadette Breiden, Jonathan O. Babalola, Konrad Sandhoff   +3 more
doaj   +1 more source

Photoswitchable diacylglycerols enable optical control of protein kinase C. [PDF]

, 2016
Increased levels of the second messenger lipid diacylglycerol (DAG) induce downstream signaling events including the translocation of C1-domain-containing proteins toward the plasma membrane. Here, we introduce three light-sensitive DAGs, termed PhoDAGs,
A Betz, A Burgalossi, A Nadler, A Nadler, A Wuttke, AC Newton, Alexander Gottschalk, C Yang, Carsten Schultz, CI Bargmann, CJ Nolan, D Toullec, DA Jacobson, DA Jacobson, David J Hodson, DB Konrad, Dirk Trauner, Dmytro A Yushchenko, E Oancea, F Plenge-Tellechea, F Varoqueaux, FM Ashcroft, G Reither, GA Rutter, Guy A Rutter, H Fliegl, H Ishihara, J Basu, J Das, JA Frank, JA Lewis, James Allen Frank, Jatin Nagpal, JD Violin, JD Violin, JE Toettcher, Jeong-Seop Rhee, JM Herbert, JS Rhee, JT Fleming, KDB Wierda, L Coussens, M Almena, M Putyrski, MA Ravier, MA Ravier, MS Pessin, N Brose, N Brose, N Brose, Nils Brose, Noa Lipstein, P Bergsten, PA Marignani, PA Wender, PK Dadi, RJ Davis, S Brenner, S Corbalán-García, S Feng, T Hofmann, TR Mahoney, U Kikkawa, X Lou, Y Kurohane Kaneko, Y Zhao   +65 more
core   +3 more sources

Lipídeos na nutrição de cães e gatos: metabolismo, fontes e uso em dietas práticas e terapêuticas Lipids in dogs and cats nutrition: metabolism, sources and application in practical and therapeutic diets

Revista Brasileira de Zootecnia, 2009
A partir do desenvolvimento de métodos mais precisos para a avaliação de lipídeos, diversos compostos têm sido descobertos e estudados como forma de enriquecer e melhorar dietas para atender às necessidades dos animais.
Luciano Trevizan, Alexandre de Mello Kessler   +1 more
doaj   +1 more source

Liver-specific loss of lipin-1-mediated phosphatidic acid phosphatase activity does not mitigate intrahepatic TG accumulation in mice

Journal of Lipid Research, 2015
Lipin proteins (lipin 1, 2, and 3) regulate glycerolipid homeostasis by acting as phosphatidic acid phosphohydrolase (PAP) enzymes in the TG synthesis pathway and by regulating DNA-bound transcription factors to control gene transcription.
George G. Schweitzer, Zhouji Chen, Connie Gan, Kyle S. McCommis, Nisreen Soufi, Roman Chrast, Mayurranjan S. Mitra, Kui Yang, Richard W. Gross, Brian N. Finck   +9 more
doaj   +1 more source

A pilot study comparing the metabolic profiles of elite-level athletes from different sporting disciplines [PDF]

, 2018
Background: The outstanding performance of an elite athlete might be associated with changes in their blood metabolic profile. The aims of this study were to compare the blood metabolic profiles between moderate- and high-power and endurance elite ...
A Boldyrev, A Leibowitz, AA Ferrando, AA Smith, B Lecka-Czernik, C Fasolato, C Harteneck, C Morris, CL Hoppel, D Belelli, D Fietz, E Asmussen, E Chorell, E Pohjanen, G Lac, G Van Hall, GC Bogdanis, GD Lewis, GJ Rietjens, H Budde, H Budde, H Karlic, H Yokoyama, J Henriksson, JB Walker, JH Mitchell, JK Nicholson, JM Peake, JS Fuqua, K Goto, K Sahlin, K Sahlin, K Sato, K Sato, KR Howarth, LS Eriksson, ME Powers, MH Jacob, MH Williams, MJ Ormsbee, ML Circu, ML Goodwin, P Yin, PC Tullson, R Berton, RF Coburn, S Naz, SC Lu, SK Powers, TE Graham, W Dudzinska, YP Pitsiladis   +51 more
core   +1 more source

DIACYLGLYCEROL ACYLTRANSFERASE and DIACYLGLYCEROL KINASE Modulate Triacylglycerol and Phosphatidic Acid Production in the Plant Response to Freezing Stress1

Plant Physiology, 2018
DGAT1 and DGK2/3/5 modulate the conversion of DAG to TAG and PA, respectively, and determine cold stress tolerance in Arabidopsis. Plants accumulate the lipids phosphatidic acid (PA), diacylglycerol (DAG), and triacylglycerol (TAG) during cold stress ...
Wei-Juan Tan, Yi-Cong Yang, Ying Zhou, Liping Huang, Le Xu, Qin-Fang Chen, Lujun Yu, S. Xiao   +7 more
semanticscholar   +1 more source

Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance

Cell Reports, 2017
Serine hydrolases are a large family of multifunctional enzymes known to influence obesity. Here, we performed activity-based protein profiling to assess the functional level of serine hydrolases in liver biopsies from lean and obese humans in order to ...
Maxwell A. Ruby, Julie Massart, Devon M. Hunerdosse, Milena Schönke, Jorge C. Correia, Sharon M. Louie, Jorge L. Ruas, Erik Näslund, Daniel K. Nomura, Juleen R. Zierath   +9 more
doaj   +1 more source

Fabrication of Concentrated Palm Olein-Based Diacylglycerol Oil–Soybean Oil Blend Oil-In-Water Emulsion: In-Depth Study of the Rheological Properties and Storage Stability

Foods, 2020
The present study focused on investigating the storage stability of oil-in-water (O/W) emulsions with high oil volume fractions prepared with palm olein-based diacylglycerol oil (POL-DAG)/soybean oil (SBO) blends at 25 °C.
Siou Pei Ng, Yih Phing Khor, Hong Kwong Lim, Oi Ming Lai, Yong Wang, Yonghua Wang, Ling Zhi Cheong, Imededdine Arbi Nehdi, Lamjed Mansour, Chin Ping Tan   +9 more
doaj   +1 more source

Comparative membrane lipidomics of hepatocellular carcinoma cells reveals diacylglycerol and ceramide as key regulators of Wnt/β‐catenin signaling and tumor growth

Molecular Oncology, 2023
Hepatocellular carcinoma (HCC) is largely associated with aberrant activation of Wnt/β‐catenin signaling. Nevertheless, how membrane lipid composition is altered in HCC cells with abnormal Wnt signaling remains elusive.
Yagmur Azbazdar, Yeliz Demirci, Guillaume Heger, Dogac Ipekgil, Mustafa Karabicici, Gunes Ozhan   +5 more
doaj   +1 more source