Loss of Diacylglycerol Kinase α Enhances Macrophage Responsiveness [PDF]
Frontiers in Immunology, 2021 The diacylglycerol kinases (DGKs) are a family of enzymes responsible for the conversion of diacylglycerol (DAG) to phosphatidic acid (PA). In addition to their primary function in lipid metabolism, DGKs have recently been identified as potential ...
Laryssa C. Manigat +7 more
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Diacylglycerol kinase alpha regulates post-hepatectomy liver regeneration [PDF]
Scientific ReportsDiacylglycerol kinases (DGKs) phosphorylate diacylglycerol to generate phosphatidic acid, which plays important roles in intracellular signal transduction. DGKα is reportedly associated with progression of tumors, including hepatocellular carcinomas, but
Hiroki Nakamoto +5 more
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Structure of membrane diacylglycerol kinase in lipid bilayers [PDF]
Communications Biology, 2021 Jianping Li et al. present the homo-trimeric structure of the small integral membrane protein diacylglycerol kinase (DgkA) in phospholipid bilayers determined by magic angle spinning solid-state NMR spectroscopy.
Jianping Li +9 more
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The Role of Diacylglycerol Kinase in the Amelioration of Diabetic Nephropathy [PDF]
Molecules, 2022 The drastic increase in the number of patients with diabetes and its complications is a global issue. Diabetic nephropathy, the leading cause of chronic kidney disease, significantly affects patients’ quality of life and medical expenses.
Daiki Hayashi, Yasuhito Shirai
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Targeting diacylglycerol kinase α impairs lung tumorigenesis by inhibiting cyclin D3 [PDF]
Thoracic Cancer, 2023 Background Diacylglycerol kinase α (DGKA) is the first member discovered from the diacylglycerol kinase family, and it has been linked to the progression of various types of tumors. However, it is unclear whether DGKA is linked to the development of lung
Dong Zhou +9 more
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Diacylglycerol kinase η colocalizes and interacts with apoptosis signal-regulating kinase 3 in response to osmotic shock [PDF]
Biochemistry and Biophysics Reports, 2021 Diacylglycerol kinase (DGK) η translocates from the cytoplasm to punctate vehicles via osmotic shock. Apoptosis signal-regulating kinase (ASK) 3 (MAP kinase kinase kinase (MAPKKK) 15) is also reported to respond to osmotic shock.
Yuji Suzuki +3 more
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Diacylglycerol kinase δ is required for skeletal muscle development and regeneration [PDF]
FASEB BioAdvancesDiacylglycerol kinase δ (DGKδ) phosphorylates diacylglycerol to produce phosphatidic acid. Previously, we demonstrated that down‐regulation of DGKδ suppresses the myogenic differentiation of C2C12 myoblasts.
Hiromichi Sakai +4 more
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SEC14 phospholipid transfer protein is involved in lipid signaling-mediated plant immune responses in Nicotiana benthamiana. [PDF]
PLoS ONE, 2014 We previously identified a gene related to the SEC14-gene phospholipid transfer protein superfamily that is induced in Nicotiana benthamiana (NbSEC14) in response to infection with Ralstonia solanacearum. We here report that NbSEC14 plays a role in plant
Akinori Kiba +5 more
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DGKζ exerts greater control than DGKα over CD8+ T cell activity and tumor inhibition
OncoImmunology, 2021 Two isoforms of diacylglycerol kinases (DGKs), DGKα and DGKζ, are primarily responsible for terminating DAG-mediated activation of Ras and PKCθ pathways in T cells.
Junchen Gu +11 more
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Insights into Activation Mechanisms of Store-Operated TRPC1 Channels in Vascular Smooth Muscle. [PDF]
, 2020 In vascular smooth muscle cells (VMSCs), the stimulation of store-operated channels (SOCs) mediate Ca2+ influx pathways which regulate important cellular functions including contraction, proliferation, migration, and growth that are associated with the ...
Albert, AP +3 more
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