Results 11 to 20 of about 73,225 (285)
Regulation of Macropinocytosis by Diacylglycerol Kinase ζ.
PLoS ONE, 2015 Macropinosomes arise from the closure of plasma membrane ruffles to bring about the non-selective uptake of nutrients and solutes into cells. The morphological changes underlying ruffle formation and macropinosome biogenesis are driven by actin ...
Ryan Ard +6 more
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The Immunomodulatory Functions of Diacylglycerol Kinase ζ [PDF]
Frontiers in Cell and Developmental Biology, 2016 The generation of diacylglycerol (DAG) is critical for promoting immune cell activation, regulation, and function. Diacylglycerol kinase ζ (DGKζ) serves as an important negative regulator of DAG by enzymatically converting DAG into phosphatidic acid (PA)
Brenal Singh, Taku Kambayashi
doaj +4 more sources
Editorial: Diacylglycerol Kinase Signalling [PDF]
Frontiers in Cell and Developmental Biology, 2017 Isabel Merida +3 more
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Diacylglycerol Kinase-ε: Properties and Biological Roles [PDF]
Frontiers in Cell and Developmental Biology, 2016 In mammals there are at least 10 isoforms of diacylglycerol kinases (DGK). All catalyze the phosphorylation of diacylglycerol (DAG) to phosphatidic acid (PA). Among DGK isoforms, DGKε has several unique features.
Richard M Epand +7 more
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Prokaryotic Diacylglycerol Kinase and Undecaprenol Kinase [PDF]
Annual Review of Biophysics, 2012 Prokaryotic diacylglycerol kinase (DAGK) and undecaprenol kinase (UDPK) are the lone members of a family of multispan membrane enzymes that are very small, lack relationships to any other family of proteins—including water soluble kinases—and exhibit an unusual structure and active site architecture.
Charles R. Sanders, Wade D. Van Horn
openaire +3 more sources
Phosphatidylinositol (4,5)-bisphosphate turnover by INP51 regulates the cell wall integrity pathway in "Saccharomyces cerevisiae" [PDF]
, 2004 Signal transduction pathways are important for the cell to transduce external or internal stimuli where second messengers play an important role as mediators of the stimuli. One important group of second messengers are the phosphoinositide family present
Morales-Johansson, Helena
core +2 more sources
Diacylglycerol Kinases in Signal Transduction
International Journal of Molecular Sciences, 2022 In recent years, the significant research efforts put into the clarification of the PI3K/AKT/mTOR pathway resulted in the approval of the first targeted therapies based on lipid kinase inhibitors [...]
Sara Centonze, Gianluca Baldanzi
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Scientific Reports, 2023 Stimulation of glucose uptake in response to ischemic metabolic stress is important for cardiomyocyte function and survival. Chronic exposure of cardiomyocytes to fatty acids (FA) impairs the stimulation of glucose uptake, whereas induction of lipid ...
Ettore Vanni +3 more
doaj +1 more source
RalA, PLD and mTORC1 Are Required for Kinase-Independent Pathways in DGKβ-Induced Neurite Outgrowth
Biomolecules, 2021 Diacylglycerol kinase β (DGKβ) is an enzyme that converts diacylglycerol to phosphatidic acid and is mainly expressed in the cerebral cortex, hippocampus and striatum.
Takuya Kano +7 more
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Insulin Action on Polyunsaturated Phosphatidic Acid Formation in Rat Brain: An “In Vitro” Model with Synaptic Endings from Cerebral Cortex and Hippocampus [PDF]
, 2009 The highly efficient formation of phosphatidic acid from exogenous 1-stearoyl-2-arachidonoyl-sn-glycerol (SAG) in rat brain synaptic nerve endings (synaptosomes) from cerebral cortex and hippocampus is reported.
Giusto, Norma Maria +2 more
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