Diacylglycerol kinase η colocalizes and interacts with apoptosis signal-regulating kinase 3 in response to osmotic shock [PDF]
Biochemistry and Biophysics Reports, 2021 Diacylglycerol kinase (DGK) η translocates from the cytoplasm to punctate vehicles via osmotic shock. Apoptosis signal-regulating kinase (ASK) 3 (MAP kinase kinase kinase (MAPKKK) 15) is also reported to respond to osmotic shock.
Yuji Suzuki +3 more
doaj +3 more sources
Loss of Diacylglycerol Kinase α Enhances Macrophage Responsiveness [PDF]
Frontiers in Immunology, 2021 The diacylglycerol kinases (DGKs) are a family of enzymes responsible for the conversion of diacylglycerol (DAG) to phosphatidic acid (PA). In addition to their primary function in lipid metabolism, DGKs have recently been identified as potential ...
Laryssa C. Manigat +7 more
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Diacylglycerol kinase alpha regulates post-hepatectomy liver regeneration [PDF]
Scientific ReportsDiacylglycerol kinases (DGKs) phosphorylate diacylglycerol to generate phosphatidic acid, which plays important roles in intracellular signal transduction. DGKα is reportedly associated with progression of tumors, including hepatocellular carcinomas, but
Hiroki Nakamoto +5 more
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Structure of membrane diacylglycerol kinase in lipid bilayers [PDF]
Communications Biology, 2021 Jianping Li et al. present the homo-trimeric structure of the small integral membrane protein diacylglycerol kinase (DgkA) in phospholipid bilayers determined by magic angle spinning solid-state NMR spectroscopy.
Jianping Li +9 more
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The Role of Diacylglycerol Kinase in the Amelioration of Diabetic Nephropathy [PDF]
Molecules, 2022 The drastic increase in the number of patients with diabetes and its complications is a global issue. Diabetic nephropathy, the leading cause of chronic kidney disease, significantly affects patients’ quality of life and medical expenses.
Daiki Hayashi, Yasuhito Shirai
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A dual diacylglycerol kinase (DGK) alpha/zeta inhibitor augments the activity of human tumor infiltrating lymphocytes in in vivo and ex vivo models [PDF]
OncoImmunologyEndogenous or adoptively transferred tumor-infiltrating lymphocytes (TILs) often lose their functional capacity due to the activation of intrinsic inhibitory pathways, which then limits their ability to control tumor growth.
Phurin Areesawangkit +20 more
doaj +2 more sources
Targeting diacylglycerol kinase α impairs lung tumorigenesis by inhibiting cyclin D3 [PDF]
Thoracic Cancer, 2023 Background Diacylglycerol kinase α (DGKA) is the first member discovered from the diacylglycerol kinase family, and it has been linked to the progression of various types of tumors. However, it is unclear whether DGKA is linked to the development of lung
Dong Zhou +9 more
doaj +2 more sources
Diacylglycerol kinase δ is required for skeletal muscle development and regeneration [PDF]
FASEB BioAdvancesDiacylglycerol kinase δ (DGKδ) phosphorylates diacylglycerol to produce phosphatidic acid. Previously, we demonstrated that down‐regulation of DGKδ suppresses the myogenic differentiation of C2C12 myoblasts.
Hiromichi Sakai +4 more
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Editorial: Diacylglycerol Kinase Signalling [PDF]
Frontiers in Cell and Developmental Biology, 2017 Isabel Merida +3 more
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<i>Staphylococcus aureus</i> uses a GGDEF protein to recruit diacylglycerol kinase to the membrane for lipid recycling. [PDF]
Proc Natl Acad Sci U S AMychack A +4 more
europepmc +3 more sources