Results 21 to 30 of about 76,688 (279)

DGKζ exerts greater control than DGKα over CD8+ T cell activity and tumor inhibition

OncoImmunology, 2021
Two isoforms of diacylglycerol kinases (DGKs), DGKα and DGKζ, are primarily responsible for terminating DAG-mediated activation of Ras and PKCθ pathways in T cells.
Junchen Gu, Cindy Wang, Carolyn Cao, Jinwen Huang, Sandra Holzhauer, Heshani Desilva, Erin M. Wesley, Douglas B. Evans, Joseph Benci, Michael Wichroski, Susan Wee, Matthew J. Riese   +11 more
doaj   +1 more source

SEC14 phospholipid transfer protein is involved in lipid signaling-mediated plant immune responses in Nicotiana benthamiana. [PDF]

PLoS ONE, 2014
We previously identified a gene related to the SEC14-gene phospholipid transfer protein superfamily that is induced in Nicotiana benthamiana (NbSEC14) in response to infection with Ralstonia solanacearum. We here report that NbSEC14 plays a role in plant
Akinori Kiba, Ivan Galis, Yuko Hojo, Kouhei Ohnishi, Hirofumi Yoshioka, Yasufumi Hikichi   +5 more
doaj   +1 more source

Phosphatidylinositol (4,5)-bisphosphate turnover by INP51 regulates the cell wall integrity pathway in "Saccharomyces cerevisiae" [PDF]

, 2004
Signal transduction pathways are important for the cell to transduce external or internal stimuli where second messengers play an important role as mediators of the stimuli. One important group of second messengers are the phosphoinositide family present
Morales-Johansson, Helena
core   +2 more sources

Prokaryotic Diacylglycerol Kinase and Undecaprenol Kinase [PDF]

Annual Review of Biophysics, 2012
Prokaryotic diacylglycerol kinase (DAGK) and undecaprenol kinase (UDPK) are the lone members of a family of multispan membrane enzymes that are very small, lack relationships to any other family of proteins—including water soluble kinases—and exhibit an unusual structure and active site architecture.
Wade D, Van Horn, Charles R, Sanders
openaire   +2 more sources

Insights into Activation Mechanisms of Store-Operated TRPC1 Channels in Vascular Smooth Muscle. [PDF]

, 2020
In vascular smooth muscle cells (VMSCs), the stimulation of store-operated channels (SOCs) mediate Ca2+ influx pathways which regulate important cellular functions including contraction, proliferation, migration, and growth that are associated with the ...
Albert, AP, Baudel, MASM-A, Large, WA, Shi, J   +3 more
core   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Differential intracellular management of fatty acids impacts on metabolic stress-stimulated glucose uptake in cardiomyocytes

Scientific Reports, 2023
Stimulation of glucose uptake in response to ischemic metabolic stress is important for cardiomyocyte function and survival. Chronic exposure of cardiomyocytes to fatty acids (FA) impairs the stimulation of glucose uptake, whereas induction of lipid ...
Ettore Vanni, Karina Lindner, Anne-Claude Gavin, Christophe Montessuit   +3 more
doaj   +1 more source

RalA, PLD and mTORC1 Are Required for Kinase-Independent Pathways in DGKβ-Induced Neurite Outgrowth

Biomolecules, 2021
Diacylglycerol kinase β (DGKβ) is an enzyme that converts diacylglycerol to phosphatidic acid and is mainly expressed in the cerebral cortex, hippocampus and striatum.
Takuya Kano, Ryosuke Tsumagari, Akio Nakashima, Ushio Kikkawa, Shuji Ueda, Minoru Yamanoue, Nobuyuki Takei, Yasuhito Shirai   +7 more
doaj   +1 more source

Insulin Action on Polyunsaturated Phosphatidic Acid Formation in Rat Brain: An “In Vitro” Model with Synaptic Endings from Cerebral Cortex and Hippocampus [PDF]

, 2009
The highly efficient formation of phosphatidic acid from exogenous 1-stearoyl-2-arachidonoyl-sn-glycerol (SAG) in rat brain synaptic nerve endings (synaptosomes) from cerebral cortex and hippocampus is reported.
Giusto, Norma Maria, Ilincheta, Monica Graciela, Zulian, Sandra Edith   +2 more
core   +1 more source

Photoswitchable diacylglycerols enable optical control of protein kinase C. [PDF]

, 2016
Increased levels of the second messenger lipid diacylglycerol (DAG) induce downstream signaling events including the translocation of C1-domain-containing proteins toward the plasma membrane. Here, we introduce three light-sensitive DAGs, termed PhoDAGs,
A Betz, A Burgalossi, A Nadler, A Nadler, A Wuttke, AC Newton, Alexander Gottschalk, C Yang, Carsten Schultz, CI Bargmann, CJ Nolan, D Toullec, DA Jacobson, DA Jacobson, David J Hodson, DB Konrad, Dirk Trauner, Dmytro A Yushchenko, E Oancea, F Plenge-Tellechea, F Varoqueaux, FM Ashcroft, G Reither, GA Rutter, Guy A Rutter, H Fliegl, H Ishihara, J Basu, J Das, JA Frank, JA Lewis, James Allen Frank, Jatin Nagpal, JD Violin, JD Violin, JE Toettcher, Jeong-Seop Rhee, JM Herbert, JS Rhee, JT Fleming, KDB Wierda, L Coussens, M Almena, M Putyrski, MA Ravier, MA Ravier, MS Pessin, N Brose, N Brose, N Brose, Nils Brose, Noa Lipstein, P Bergsten, PA Marignani, PA Wender, PK Dadi, RJ Davis, S Brenner, S Corbalán-García, S Feng, T Hofmann, TR Mahoney, U Kikkawa, X Lou, Y Kurohane Kaneko, Y Zhao   +65 more
core   +3 more sources