Results 31 to 40 of about 916,035 (361)
DGKζ exerts greater control than DGKα over CD8+ T cell activity and tumor inhibition
OncoImmunology, 2021 Two isoforms of diacylglycerol kinases (DGKs), DGKα and DGKζ, are primarily responsible for terminating DAG-mediated activation of Ras and PKCθ pathways in T cells.
Junchen Gu +11 more
doaj +1 more source
SEC14 phospholipid transfer protein is involved in lipid signaling-mediated plant immune responses in Nicotiana benthamiana. [PDF]
PLoS ONE, 2014 We previously identified a gene related to the SEC14-gene phospholipid transfer protein superfamily that is induced in Nicotiana benthamiana (NbSEC14) in response to infection with Ralstonia solanacearum. We here report that NbSEC14 plays a role in plant
Akinori Kiba +5 more
doaj +1 more source
The Emerging Roles of Diacylglycerol Kinase (DGK) in Plant Stress Tolerance, Growth, and Development
Agronomy, 2020 Diacylglycerol kinase (DGK) is recognized as the key enzyme of the lipid signaling pathway, which involves the transduction of messages from hormones, neurotransmitters, and immunologic and growth factors.
Idrice Carther Kue Foka +5 more
semanticscholar +1 more source
Definitions, 2020 Diacylglycerol kinase zeta (1117 aa, ~124 kDa) is encoded by the human DGKZ gene. This protein is involved in the phosphorylation of the second messenger molecule diacylglycerol.
semanticscholar +1 more source
Definitions, 2020 Diacylglycerol kinase eta (1220 aa, ~135 kDa) is encoded by the human DGKH gene. This protein plays a role in the phosphorylation of diacylglycerol.
semanticscholar +1 more source
The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression
Hepatology, EarlyView., 2022 Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro +14 more
wiley +1 more source
Diacylglycerol Kinases in Signal Transduction
International Journal of Molecular Sciences, 2022 In recent years, the significant research efforts put into the clarification of the PI3K/AKT/mTOR pathway resulted in the approval of the first targeted therapies based on lipid kinase inhibitors [...]
Sara Centonze, Gianluca Baldanzi
openaire +3 more sources
Scientific Reports, 2023 Stimulation of glucose uptake in response to ischemic metabolic stress is important for cardiomyocyte function and survival. Chronic exposure of cardiomyocytes to fatty acids (FA) impairs the stimulation of glucose uptake, whereas induction of lipid ...
Ettore Vanni +3 more
doaj +1 more source
RalA, PLD and mTORC1 Are Required for Kinase-Independent Pathways in DGKβ-Induced Neurite Outgrowth
Biomolecules, 2021 Diacylglycerol kinase β (DGKβ) is an enzyme that converts diacylglycerol to phosphatidic acid and is mainly expressed in the cerebral cortex, hippocampus and striatum.
Takuya Kano +7 more
doaj +1 more source
Diacylglycerol kinase δ is required for skeletal muscle development and regeneration. [PDF]
FASEB BioadvDiacylglycerol kinase δ (DGKδ) phosphorylates diacylglycerol to produce phosphatidic acid. Previously, we demonstrated that down‐regulation of DGKδ suppresses the myogenic differentiation of C2C12 myoblasts.
Sakai H +4 more
europepmc +2 more sources