Results 31 to 40 of about 73,225 (285)
Journal of Lipid Research, 1986 The stereospecificity of monoacylglycerol acyltransferase from rat intestinal mucosa and suckling rat liver microsomes was examined using sn-1,2-diacylglycerol kinase from Escherichia coli.
R A Coleman +3 more
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Quantitative Analysis of Cellular Diacylglycerol Content
Bio-Protocol, 2014 Diacylglycerol (DAG) is a bioactive lipid with diverse biological roles. DAG transiently accumulates in a membrane upon receipt of an appropriate stimulus that activates phospholipase C to cleave phospholipids.
Fikadu Tafesse +2 more
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Cell Death and Disease, 2022 Diacylglycerol kinase ζ (DGKZ) is a diacylglycerol kinase that metabolizes diacylglycerol to yield phosphatidic acid, and its function in breast cancer progression remains unclear. In this study, via screening of a CRISPR-Cas9 knockout library containing
Yuanyuan Zhao +6 more
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Endocannabinoids and diacylglycerol kinase activity
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2011 Mammalian diacylglycerol kinases are a family of enzymes that catalyze the phosphorylation of diacylglycerol to produce phosphatidic acid. The extent of interaction of these enzymes with monoacylglycerols is the focus of the present study. Because of the structural relationship between mono- and diacylglycerols, one might expect the monoacylglycerols ...
Matthew K. Topham +4 more
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Diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities. [PDF]
PLoS ONE, 2010 Diacylglycerol kinase (DGK) is an enzyme that phosphorylates diacylglycerol (DG) to produce phosphatidic acid (PA). DGKβ is widely distributed in the central nervous system, such as the olfactory bulb, cerebral cortex, striatum, and hippocampus.
Kenichi Kakefuda +10 more
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Diacylglycerol kinases: Relationship to other lipid kinases [PDF]
Advances in Biological Regulation, 2019 Lipid kinases regulate a wide variety of cellular functions and have emerged as one the most promising targets for drug design. Diacylglycerol kinases (DGKs) are a family of enzymes that catalyze the ATP-dependent phosphorylation of diacylglycerol (DAG) to phosphatidic acid (PtdOH).
Sandra B. Gabelli +2 more
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Signaling roles of diacylglycerol kinases [PDF]
Journal of Cellular Biochemistry, 2005 AbstractDiacylglycerol kinases (DGKs) attenuate diacylglycerol signaling by converting this lipid to phosphatidic acid (PA). The nine mammalian DGKs that have been identified are widely expressed, but each isoform has a unique tissue and subcellular distribution.
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Dual effect of reduced type I diacylglycerol kinase activity on insulin secretion from MIN6 β-cells
Journal of Pharmacological Sciences, 2019 The role of type I diacylglycerol kinases (DGKs) in the regulation of insulin secretion was investigated in MIN6 β-cells. In intracellular Ca2+ concentration ([Ca2+]i) measurement experiments, 1 μM R59949, a type I DGK inhibitor, and 10 μM DiC8, a ...
Toshiaki Sawatani +2 more
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Cochlioquinone A, an Inhibitor of Diacylglycerol Kinase.
The Journal of Antibiotics, 1995 The effects of cochlioquinone A, isolated from Drechslera sacchari, were studied in vitro and in vivo. This compound specifically inhibited diacylglycerol kinase activity with Ki = 3.1 microM. The kinetics revealed that cochlioquinone A inhibited diacylglycerol kinase in competition with ATP, and non-competitively with diacylglycerol.
Toshiki Machida +2 more
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Lipid second messengers and related enzymes in vertebrate rod outer segments
Journal of Lipid Research, 2010 Rod outer segments (ROSs) are specialized light-sensitive organelles in vertebrate photoreceptor cells. Lipids in ROS are of considerable importance, not only in providing an adequate environment for efficient phototransduction, but also in originating ...
Norma M. Giusto +3 more
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