Results 41 to 50 of about 73,225 (285)
Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase. [PDF]
, 1994 Intracellular pathways leading from membrane receptor engagement to apoptotic cell death are still poorly characterized. We investigated the intracellular signaling generated after cross-linking of CD95 (Fas/Apo-1 antigen), a broadly expressed cell ...
Azuma, M +7 more
core +2 more sources
Diacylglycerol kinase control of protein kinase C
Biochemical Journal, 2019 Abstract The diacylglycerol kinases (DGK) are lipid kinases that transform diacylglycerol (DAG) into phosphatidic acid (PA) in a reaction that terminates DAG-based signals. DGK provide negative regulation to conventional and novel protein kinase C (PKC) enzymes, limiting local DAG availability in a tissue- and subcellular-restricted ...
Isabel Mérida +3 more
openaire +4 more sources
Diacylglycerol kinase zeta positively controls the development of iNKT-17 cells. [PDF]
PLoS ONE, 2013 Invariant natural killer T (iNKT) cells play important roles in bridging innate and adaptive immunity via rapidly producing a variety of cytokines. A small subset of iNKT cells produces IL-17 and is generated in the thymus during iNKT-cell ontogeny.
Jinhong Wu +4 more
doaj +1 more source
MicroRNA-34a enhances T cell activation by targeting diacylglycerol kinase ζ. [PDF]
PLoS ONE, 2013 The engagement of the T cell receptor (TCR) induces the generation of diacylglycerol (DAG), an important second messenger activating both the Ras/Erk and PKCθ/NFκB pathways.
Jinwook Shin, Danli Xie, Xiao-Ping Zhong
doaj +1 more source
Diacylglycerol Kinase Signalling
, 2017 Diacylglycerol kinases (DGKs) phosphorylate diacylglycerol (DG), catalyzing its conversion into phosphatidic acid (PA). This reaction attenuates membrane DG levels, limiting the localization/activation of signaling proteins that bind this lipid. Initially recognized as modulators of classical and novel PKC family members, the function of the DGK has ...
Isabel Mérida +2 more
openaire +3 more sources
Diacylglycerol Kinase Delta Promotes Lipogenesis [PDF]
Biochemistry, 2013 We have studied the relationship between diacylglycerol kinase delta (DGKδ) and lipogenesis. There is a marked increase in the expression of DGKδ during the differentiation of 3T3-L1 cells to adipocytes, as well as in the synthesis of neutral and polar lipids.
Yulia V. Shulga +12 more
openaire +3 more sources
Diacylglycerol kinases as sources of phosphatidic acid [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2009 There are ten mammalian diacylglycerol kinases (DGKs) whose primary role is to terminate diacylglycerol (DAG) signaling. However, it is becoming increasingly apparent that DGKs also influence signaling events through their product, phosphatidic acid (PA).
Jinjin Cai +4 more
openaire +3 more sources
Cell Reports, 2016 Synaptic transmission relies on coordinated coupling of synaptic vesicle (SV) exocytosis and endocytosis. While much attention has focused on characterizing proteins involved in SV recycling, the roles of membrane lipids and their metabolism remain ...
Hana L. Goldschmidt +5 more
doaj +1 more source
Light Activation of the Phosphoinositide Cycle in Intrinsically Photosensitive Chicken Retinal Ganglion Cells [PDF]
, 2010 Purpose: In vertebrates, intrinsically photosensitive retinal ganglion cells (ipRGCs) acting as nonvisual photoreceptors transmit environmental illumination information to the brain, regulating diverse non–image-forming tasks.
Contin, Maria Ana +5 more
core +1 more source
Arachidonoyl-specific diacylglycerol kinase ε and the endoplasmic reticulum
Frontiers in Cell and Developmental Biology, 2016 The endoplasmic reticulum (ER) comprises an interconnected membrane network, which is made up of lipid bilayer and associated proteins. This organelle plays a central role in the protein synthesis and sorting.
Tomoyuki Nakano +6 more
doaj +1 more source