Results 41 to 50 of about 76,688 (279)
Diacylglycerol kinases regulate TRPV1 channel activity [PDF]
Journal of Biological Chemistry, 2020 The transient receptor potential vanilloid 1 (TRPV1) channel is activated by heat and by capsaicin, the pungent compound in chili peppers. Calcium influx through TRPV1 has been shown to activate a calcium-sensitive phospholipase C (PLC) enzyme and to lead to a robust decrease in phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] levels, which is a major
Luyu Liu, Yevgen Yudin, Tibor Rohacs
openaire +2 more sources
Regulation of Macropinocytosis by Diacylglycerol Kinase ζ.
PLoS ONE, 2015 Macropinosomes arise from the closure of plasma membrane ruffles to bring about the non-selective uptake of nutrients and solutes into cells. The morphological changes underlying ruffle formation and macropinosome biogenesis are driven by actin ...
Ryan Ard +6 more
doaj +1 more source
Cell Death and Disease, 2022 Diacylglycerol kinase ζ (DGKZ) is a diacylglycerol kinase that metabolizes diacylglycerol to yield phosphatidic acid, and its function in breast cancer progression remains unclear. In this study, via screening of a CRISPR-Cas9 knockout library containing
Yuanyuan Zhao +6 more
doaj +1 more source
Diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities. [PDF]
PLoS ONE, 2010 Diacylglycerol kinase (DGK) is an enzyme that phosphorylates diacylglycerol (DG) to produce phosphatidic acid (PA). DGKβ is widely distributed in the central nervous system, such as the olfactory bulb, cerebral cortex, striatum, and hippocampus.
Kenichi Kakefuda +10 more
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Dual effect of reduced type I diacylglycerol kinase activity on insulin secretion from MIN6 β-cells
Journal of Pharmacological Sciences, 2019 The role of type I diacylglycerol kinases (DGKs) in the regulation of insulin secretion was investigated in MIN6 β-cells. In intracellular Ca2+ concentration ([Ca2+]i) measurement experiments, 1 μM R59949, a type I DGK inhibitor, and 10 μM DiC8, a ...
Toshiaki Sawatani +2 more
doaj +1 more source
Quantitative Analysis of Cellular Diacylglycerol Content
Bio-Protocol, 2014 Diacylglycerol (DAG) is a bioactive lipid with diverse biological roles. DAG transiently accumulates in a membrane upon receipt of an appropriate stimulus that activates phospholipase C to cleave phospholipids.
Fikadu Tafesse +2 more
doaj +1 more source
Lipid second messengers and related enzymes in vertebrate rod outer segments
Journal of Lipid Research, 2010 Rod outer segments (ROSs) are specialized light-sensitive organelles in vertebrate photoreceptor cells. Lipids in ROS are of considerable importance, not only in providing an adequate environment for efficient phototransduction, but also in originating ...
Norma M. Giusto +3 more
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Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase. [PDF]
, 1994 Intracellular pathways leading from membrane receptor engagement to apoptotic cell death are still poorly characterized. We investigated the intracellular signaling generated after cross-linking of CD95 (Fas/Apo-1 antigen), a broadly expressed cell ...
Azuma, M +7 more
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The Immunomodulatory Functions of Diacylglycerol Kinase ζ
Frontiers in Cell and Developmental Biology, 2016 The generation of diacylglycerol (DAG) is critical for promoting immune cell activation, regulation, and function. Diacylglycerol kinase ζ (DGKζ) serves as an important negative regulator of DAG by enzymatically converting DAG into phosphatidic acid (PA)
Brenal Singh, Taku Kambayashi
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Diacylglycerol Kinase-ε: Properties and Biological Roles
Frontiers in Cell and Developmental Biology, 2016 In mammals there are at least 10 isoforms of diacylglycerol kinases (DGK). All catalyze the phosphorylation of diacylglycerol (DAG) to phosphatidic acid (PA). Among DGK isoforms, DGKε has several unique features.
Richard M Epand +7 more
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