Results 41 to 50 of about 916,035 (361)
British Journal of Pharmacology, EarlyView., 2023 Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi +6 more
wiley +1 more source
Gαq signalling from endosomes: A new conundrum
British Journal of Pharmacology, EarlyView., 2023 Abstract G‐protein‐coupled receptors (GPCRs) constitute the largest family of membrane receptors, and are involved in the transmission of a variety of extracellular stimuli such as hormones, neurotransmitters, light and odorants into intracellular responses.
Carole Daly, Bianca Plouffe
wiley +1 more source
Plant Physiology, 2018 DGAT1 and DGK2/3/5 modulate the conversion of DAG to TAG and PA, respectively, and determine cold stress tolerance in Arabidopsis. Plants accumulate the lipids phosphatidic acid (PA), diacylglycerol (DAG), and triacylglycerol (TAG) during cold stress ...
Wei-Juan Tan +7 more
semanticscholar +1 more source
Diacylglycerol kinases in membrane trafficking [PDF]
Cellular Logistics, 2015 Diacylglycerol kinases (DGKs) belong to a family of cytosolic kinases that regulate the phosphorylation of diacylglycerol (DAG), converting it into phosphatidic acid (PA). There are 10 known mammalian DGK isoforms, each with a different tissue distribution and substrate specificity.
Shuwei Xie +2 more
openaire +3 more sources
Diacylglycerol kinase η colocalizes and interacts with apoptosis signal-regulating kinase 3 in response to osmotic shock. [PDF]
Biochem Biophys Rep, 2021 Diacylglycerol kinase (DGK) η translocates from the cytoplasm to punctate vehicles via osmotic shock. Apoptosis signal-regulating kinase (ASK) 3 (MAP kinase kinase kinase (MAPKKK) 15) is also reported to respond to osmotic shock.
Suzuki Y +3 more
europepmc +2 more sources
Diacylglycerol kinase η1 is a high affinity isozyme for diacylglycerol [PDF]
FEBS Letters, 2015 Diacylglycerol kinase (DGK) η plays important roles in various patho‐physiological events such as oncogenesis. In this study, we performed an enzymological characterization of DGKη splice variant 1 (DGKη1). The K m value for diacylglycerol was 0.14 mol%.
Hiromichi Sakai +3 more
openaire +3 more sources
Phosphatidic acid production regulated by receptors with liganddependent tyrosine kinase activity
Grasas y Aceites, 1995 The present study deals with the most recent and important studies on the relationship between transmembrane receptors with ligand-dependent tyrosine kinase activity and cellular lipid metabolism, predominantly in generating phosphatidic acid (PA) as a ...
Fco. J. G. Muriana, V. Ruiz-Gutiérrez
doaj +1 more source
Diacylglycerol Kinases in the Coordination of Synaptic Plasticity [PDF]
Frontiers in Cell and Developmental Biology, 2016 Synaptic plasticity is activity-dependent modification of the efficacy of synaptic transmission. Although, detailed mechanisms underlying synaptic plasticity are diverse and vary at different types of synapses, diacylglycerol (DAG)-associated signaling has been considered as an important regulator of many forms of synaptic plasticity, including long ...
Dongwon Lee +3 more
openaire +4 more sources
Endocannabinoids and diacylglycerol kinase activity
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2011 Mammalian diacylglycerol kinases are a family of enzymes that catalyze the phosphorylation of diacylglycerol to produce phosphatidic acid. The extent of interaction of these enzymes with monoacylglycerols is the focus of the present study. Because of the structural relationship between mono- and diacylglycerols, one might expect the monoacylglycerols ...
Matthew K. Topham +4 more
openaire +3 more sources
Quantitative Analysis of Cellular Diacylglycerol Content
Bio-Protocol, 2014 Diacylglycerol (DAG) is a bioactive lipid with diverse biological roles. DAG transiently accumulates in a membrane upon receipt of an appropriate stimulus that activates phospholipase C to cleave phospholipids.
Fikadu Tafesse +2 more
doaj +1 more source