Results 51 to 60 of about 73,225 (285)
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Diacylglycerol Kinase Inhibition and Vascular Function [PDF]
Current Enzyme Inhibition, 2009 Diacylglycerol kinases (DGKs), a family of lipid kinases, convert diacylglycerol (DG) to phosphatidic acid (PA). Acting as a second messenger, DG activates protein kinase C (PKC). PA, a signaling lipid, regulates diverse functions involved in physiological responses.
R. Clinton Webb +3 more
openaire +3 more sources
Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells
FEBS Letters, EarlyView.Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan +2 more
wiley +1 more source
Lipid activation of protein kinases
Journal of Lipid Research, 2009 Lipids acutely control the amplitude, duration, and subcellular location of signaling by lipid second messenger-responsive kinases. Typically, this activation is controlled by membrane-targeting modules that allosterically control the function of kinase ...
Alexandra C. Newton
doaj +1 more source
Diacylglycerol kinase θ: Regulation and stability [PDF]
Advances in Biological Regulation, 2013 Given the well-established roles of diacylglycerol (DAG) and phosphatidic acid (PtdOH) in a variety of signaling cascades, it is not surprising that there is an increasing interest in understanding their physiological roles and mechanisms that regulate their cellular levels.
Elizabeth J. Petro +3 more
openaire +3 more sources
Genetic Engineering Methods in Primary T Cells
Advanced Therapeutics, EarlyView.Primary T cells can be engineered to confer them with novel therapeutic functions, allowing them to treat a variety of conditions. Genetic engineering can be either stable or transient, aiming to either express or inhibit a target gene. This review discusses the various genetic engineering tools available as well as their characteristics and ...
Anthony Youssef, Hui‐Shan Li
wiley +1 more source
Advanced Science, EarlyView.Chen et al. identified a metabolic gene prognostic signature with machine‐learning framework and assessed the prognostic value in independent CRC cohorts. The metabolic signature subtypes are characterized by specific metabolic and proteomic characteristics, and associated with distinct molecular pathway and therapeutic potential.
Hao Chen +12 more
wiley +1 more source
Exercise and MEF2–HDAC interactions.
, 2007 Exercise increases the metabolic capacity of skeletal muscle, which improves whole-body energy homeostasis and contributes to the positive health benefits of exercise.
McGee, Sean L.
core +1 more source
Effect of diet-induced obesity on protein expression in insulin signalling pathways of skeletal muscle in male Wistar rats [PDF]
, 2012 BACKGROUND: The prevalence of diet-induced obesity is increasing globally, and posing significant health problems for millions of people worldwide. Diet-induced obesity is a major contributor to the global pandemic of type 2 diabetes mellitus.
Abubakari, Abdul-Razak +5 more
core +2 more sources
Diacylglycerol kinases in the regulation of dendritic spines [PDF]
Journal of Neurochemistry, 2010 J. Neurochem. (2010) 112, 577–587.AbstractDiacylglycerol (DAG) is an important lipid‐signaling molecule that binds and activates various downstream effectors. Tight control over the production and removal of DAG is important in maintaining the dynamic responses of the DAG signaling system to a changing environment.
Kim, K, Yang, J, Kim, E Kim, Eunjoon
openaire +4 more sources