Results 51 to 60 of about 76,688 (279)
Diacylglycerol Kinase Inhibition and Vascular Function [PDF]
Current Enzyme Inhibition, 2009 Diacylglycerol kinases (DGKs), a family of lipid kinases, convert diacylglycerol (DG) to phosphatidic acid (PA). Acting as a second messenger, DG activates protein kinase C (PKC). PA, a signaling lipid, regulates diverse functions involved in physiological responses.
Hyehun, Choi +3 more
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Nuclear diacylglycerol kinases: regulation and roles [PDF]
Frontiers in Bioscience, 2007 The diacylglycerol-kinases are a family of related lipid kinases. There are currently 10 known isoforms of diacylglycerol kinases that are categorized into five groups based on similarities in their primary sequence. All of these enzymes catalyze the transfer of the gamma-phosphate of ATP to one lipid second messenger, diacylglycerol, thereby ...
M. Raben Daniel
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Signaling roles of diacylglycerol kinases [PDF]
Journal of Cellular Biochemistry, 2005 AbstractDiacylglycerol kinases (DGKs) attenuate diacylglycerol signaling by converting this lipid to phosphatidic acid (PA). The nine mammalian DGKs that have been identified are widely expressed, but each isoform has a unique tissue and subcellular distribution.
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Diacylglycerol kinase zeta positively controls the development of iNKT-17 cells. [PDF]
PLoS ONE, 2013 Invariant natural killer T (iNKT) cells play important roles in bridging innate and adaptive immunity via rapidly producing a variety of cytokines. A small subset of iNKT cells produces IL-17 and is generated in the thymus during iNKT-cell ontogeny.
Jinhong Wu +4 more
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MicroRNA-34a enhances T cell activation by targeting diacylglycerol kinase ζ. [PDF]
PLoS ONE, 2013 The engagement of the T cell receptor (TCR) induces the generation of diacylglycerol (DAG), an important second messenger activating both the Ras/Erk and PKCθ/NFκB pathways.
Jinwook Shin, Danli Xie, Xiao-Ping Zhong
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Diacylglycerol kinase θ: Regulation and stability [PDF]
Advances in Biological Regulation, 2013 Given the well-established roles of diacylglycerol (DAG) and phosphatidic acid (PtdOH) in a variety of signaling cascades, it is not surprising that there is an increasing interest in understanding their physiological roles and mechanisms that regulate their cellular levels.
Becky, Tu-Sekine +3 more
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Cell Reports, 2016 Synaptic transmission relies on coordinated coupling of synaptic vesicle (SV) exocytosis and endocytosis. While much attention has focused on characterizing proteins involved in SV recycling, the roles of membrane lipids and their metabolism remain ...
Hana L. Goldschmidt +5 more
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Endocannabinoids and diacylglycerol kinase activity
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2011 Mammalian diacylglycerol kinases are a family of enzymes that catalyze the phosphorylation of diacylglycerol to produce phosphatidic acid. The extent of interaction of these enzymes with monoacylglycerols is the focus of the present study. Because of the structural relationship between mono- and diacylglycerols, one might expect the monoacylglycerols ...
Gantayet, Arpita +4 more
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Arachidonoyl-specific diacylglycerol kinase ε and the endoplasmic reticulum
Frontiers in Cell and Developmental Biology, 2016 The endoplasmic reticulum (ER) comprises an interconnected membrane network, which is made up of lipid bilayer and associated proteins. This organelle plays a central role in the protein synthesis and sorting.
Tomoyuki Nakano +6 more
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Light Activation of the Phosphoinositide Cycle in Intrinsically Photosensitive Chicken Retinal Ganglion Cells [PDF]
, 2010 Purpose: In vertebrates, intrinsically photosensitive retinal ganglion cells (ipRGCs) acting as nonvisual photoreceptors transmit environmental illumination information to the brain, regulating diverse non–image-forming tasks.
Contin, Maria Ana +5 more
core +1 more source