Results 51 to 60 of about 916,035 (361)

DGKZ promotes TGFβ signaling pathway and metastasis in triple-negative breast cancer by suppressing lipid raft-dependent endocytosis of TGFβR2

Cell Death and Disease, 2022
Diacylglycerol kinase ζ (DGKZ) is a diacylglycerol kinase that metabolizes diacylglycerol to yield phosphatidic acid, and its function in breast cancer progression remains unclear. In this study, via screening of a CRISPR-Cas9 knockout library containing
Yuanyuan Zhao, Hefen Sun, Xuan Li, Qiqi Liu, Yang Liu, Yifeng Hou, Wei Jin   +6 more
doaj   +1 more source

Regulation of signal duration and the statistical dynamics of kinase activation by scaffold proteins [PDF]

PLoS Comput Biol. 2008 Jun 27;4(6):e1000099, 2008
Scaffolding proteins that direct the assembly of multiple kinases into a spatially localized signaling complex are often essential for the maintenance of an appropriate biological response. Although scaffolds are widely believed to have dramatic effects on the dynamics of signal propagation, the mechanisms that underlie these consequences are not well ...
arxiv   +1 more source

Diacylglycerol kinases: Relationship to other lipid kinases [PDF]

Advances in Biological Regulation, 2019
Lipid kinases regulate a wide variety of cellular functions and have emerged as one the most promising targets for drug design. Diacylglycerol kinases (DGKs) are a family of enzymes that catalyze the ATP-dependent phosphorylation of diacylglycerol (DAG) to phosphatidic acid (PtdOH).
Sandra B. Gabelli, Qianqian Ma, Daniel M. Raben   +2 more
openaire   +3 more sources

Prediction of kinase inhibitor response using activity profiling, in-vitro screening, and elastic net regression [PDF]

BMC Systems Biology 2014, 8:74, 2013
Many kinase inhibitors have been approved as cancer therapies. Recently, libraries of kinase inhibitors have been extensively profiled, thus providing a map of the strength of action of each compound on a large number of its targets. These profiled libraries define drug-kinase networks that can predict the effectiveness of new untested drugs and ...
arxiv   +1 more source

The Phenotypic Spectrum of Nephropathies Associated with Mutations in Diacylglycerol Kinase ε.

Journal of the American Society of Nephrology, 2017
The recent discovery of mutations in the gene encoding diacylglycerol kinase ε (DGKE) identified a novel pathophysiologic mechanism leading to HUS and/or MPGN. We report ten new patients from eight unrelated kindreds with DGKE nephropathy.
K. Ažukaitis, E. Simkova, M. A. Majid, M. Galiano, K. Benz, K. Amann, C. Bockmeyer, Radha Gajjar, K. Meyers, H. Cheong, Bärbel Lange-Sperandio, T. Jungraithmayr, V. Frémeaux-Bacchi, C. Bergmann, C. Bereczki, M. Miklaszewska, D. Csuka, Z. Prohászka, P. Killen, P. Gipson, M. Sampson, Mathieu Lemaire, F. Schaefer   +22 more
semanticscholar   +1 more source

Diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities. [PDF]

PLoS ONE, 2010
Diacylglycerol kinase (DGK) is an enzyme that phosphorylates diacylglycerol (DG) to produce phosphatidic acid (PA). DGKβ is widely distributed in the central nervous system, such as the olfactory bulb, cerebral cortex, striatum, and hippocampus.
Kenichi Kakefuda, Atsushi Oyagi, Mitsue Ishisaka, Kazuhiro Tsuruma, Masamitsu Shimazawa, Koichi Yokota, Yasuhito Shirai, Kyoji Horie, Naoaki Saito, Junji Takeda, Hideaki Hara   +10 more
doaj   +1 more source

Diacylglycerol kinase synthesized by commensal Lactobacillus reuteri diminishes Protein Kinase C phosphorylation and histamine-mediated signaling in the mammalian intestinal epithelium

Mucosal Immunology, 2017
Lactobacillus reuteri 6475 (Lr) of the human microbiome synthesizes histamine and can suppress inflammation via type 2 histamine receptor (H2R) activation in the mammalian intestine.
B. Ganesh, A. Hall, S. Ayyaswamy, J. Nelson, R. Fultz, A. Major, A. Haag, M. Esparza, M. Lugo, S. Venable, M. Whary, J. Fox, J. Versalovic   +12 more
semanticscholar   +1 more source

Cochlioquinone A, an Inhibitor of Diacylglycerol Kinase.

The Journal of Antibiotics, 1995
The effects of cochlioquinone A, isolated from Drechslera sacchari, were studied in vitro and in vivo. This compound specifically inhibited diacylglycerol kinase activity with Ki = 3.1 microM. The kinetics revealed that cochlioquinone A inhibited diacylglycerol kinase in competition with ATP, and non-competitively with diacylglycerol.
Toshiki Machida, Hiroshi Ogawara, Kyoichiro Higashi   +2 more
openaire   +4 more sources

A novel diacylglycerol kinase α-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response[S]

Journal of Lipid Research, 2016
Diacylglycerol kinase (DGK) consists of 10 isozymes. The α-isozyme enhances the proliferation of cancer cells. However, DGKα facilitates the nonresponsive state of immunity known as T-cell anergy; therefore, DGKα enhances malignant traits and suppresses ...
Ke-Wei Liu, N. Kunii, Megumi Sakuma, Atsumi Yamaki, S. Mizuno, Mayu Sato, Hiromichi Sakai, Sayaka Kado, K. Kumagai, H. Kojima, T. Okabe, T. Nagano, Y. Shirai, F. Sakane   +13 more
semanticscholar   +1 more source

Signaling roles of diacylglycerol kinases [PDF]

Journal of Cellular Biochemistry, 2005
AbstractDiacylglycerol kinases (DGKs) attenuate diacylglycerol signaling by converting this lipid to phosphatidic acid (PA). The nine mammalian DGKs that have been identified are widely expressed, but each isoform has a unique tissue and subcellular distribution.
openaire   +3 more sources