The potential of diallyl trisulfide for cancer prevention and treatment, with mechanism insights [PDF]
Frontiers in Cell and Developmental BiologyCancer has become an important public health problem worldwide, and there is currently a lack of effective treatment and prevention strategies. Natural plant active ingredients have been proven to be a safe and highly promising method for preventing and ...
Zhaofeng Liang, Song Jiajia
exaly +6 more sources
Diallyl disulfide and diallyl trisulfide in garlic as novel therapeutic agents to overcome drug resistance in breast cancer [PDF]
Journal of Pharmaceutical Analysis, 2022 Breast cancer is one of the leading causes of cancer-related deaths in women worldwide. It is a cancer that originates from the mammary ducts and involves mutations in multiple genes.
Ramarao Malla +2 more
exaly +6 more sources
Diallyl Trisulfide, the Antifungal Component of Garlic Essential Oil and the Bioactivity of Its Nanoemulsions Formed by Spontaneous Emulsification [PDF]
Molecules, 2021 The aim of this study was to evaluate the chemical compounds of garlic essential oil (EO), and determine the antifungal efficacy of garlic EO and its major components, diallyl trisulfide and its nanoemulsions against wood-rotting fungi, Trametes hirsuta ...
Hongjia Liu
exaly +4 more sources
Diallyl Trisulfide Enhances the Survival of Multiterritory Perforator Skin Flaps [PDF]
Frontiers in Pharmacology, 2022 The multiterritory perforator flap is one of the widest flap patterns used to repair tissue defects. However, flap necrosis of the distal part is still a challenging issue for plastic surgeons.
Chengji Dong +29 more
doaj +5 more sources
Antimicrobial Effect and the Mechanism of Diallyl Trisulfide against Campylobacter jejuni [PDF]
Antibiotics, 2021 Campylobacter jejuni is an important foodborne pathogen causing campylobacteriosis. It can infect humans through the consumption of contaminated chicken products or via the direct handling of animals.
Yuanyue Tang +5 more
doaj +5 more sources
Dietary Bioactive Diallyl Trisulfide in Cancer Prevention and Treatment [PDF]
International Journal of Molecular Sciences, 2017 Bioactive dietary agents have been shown to regulate multiple cancer hallmark pathways. Epidemiologic studies have linked consumption of Allium vegetables, such as garlic and onions, to decreased incidence of cancer. Diallyl trisulfide (DATS), a bioactive compound derived from Allium vegetables, has been investigated as an anti-cancer and ...
Silvia D Stan, Stan Silvia D
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Garlic Derived Diallyl Trisulfide in Experimental Metabolic Syndrome: Metabolic Effects and Cardioprotective Role [PDF]
International Journal of Molecular Sciences, 2020 This study aimed to examine the effects of diallyl trisulfide (DATS), the most potent polysulfide derived from garlic, on metabolic syndrome and myocardial function in rats with metabolic syndrome (MetS). For that purpose, we used 36 male Wistar albino rats divided into control rats, rats with MetS and MetS rats treated with 40 mg/kg of DATS every ...
Jovana Jeremic +2 more
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Breast Cancer Selective Disruption of Actin Cytoskeleton by Diallyl Trisulfide. [PDF]
J Cancer Prev, 2022 Diallyl trisulfide (DATS) is an attractive anti-cancer phytochemical with in vitro and in vivo growth inhibitory effects against different solid tumors including breast cancer. We have shown previously that an immortalized mammary epithelial cell line (MCF-10A) is resistant to growth inhibition by DATS.
Hahm ER, Mathan SV, Singh RP, Singh SV.
europepmc +3 more sources
Diallyl Trisulfide and Cardiovascular Health: Evidence and Potential Molecular Mechanisms. [PDF]
Int J Mol SciTraditionally, garlic has a valuable role in preventing and reducing the incidence of many diseases and pathophysiological disorders. Consequently, some researchers have focused on the beneficial cardiovascular properties of diallyl trisulfide (DATS), the most potent polysulfide isolated from garlic.
Novakovic J +5 more
europepmc +3 more sources
Identification of molecular target of diallyl trisulfide in leukemic cells [PDF]
Bioscience, Biotechnology and Biochemistry, 2014 Abstract To identify the molecular target of diallyl trisulfide (DATS) in human leukemic cell line U937, we examined modification of thiol group(s) of cellular proteins by the redox 2D PAGE. A unique protein spot appeared by DATS treatment was identified to be heat shock protein 27 (HSP27).
Jun Ogihara +2 more
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