Results 11 to 20 of about 12,487 (210)

Diallyl trisulfide induces pro-apoptotic autophagy via the AMPK/SIRT1 signalling pathway in human hepatocellular carcinoma HepG2 cell line [PDF]

Food & Nutrition Research, 2023
Background: Liver cancer is associated with a high mortality rate worldwide. Hepatocellular carcinoma (HCC) constitutes a large proportion of primary liver cancers, and most of its alterations currently remain untreatable.
Shuoshuo Sun, Xiyu Liu, Xiao Wei, Shaohong Zhang, Weimin Wang   +4 more
doaj   +3 more sources

Recent Research Advances in Multi-Functional Diallyl Trisulfide (DATS): A Comprehensive Review of Characteristics, Metabolism, Pharmacodynamics, Applications, and Drug Delivery Systems. [PDF]

Int J Nanomedicine
Maoru Wang,1,* Jiangping Yu,2,* Hui Xu,3 Kexin Xu,3 Muhammad Sohail,4 Jisheng Wang,1 Hong Ning,2 Jianqiao Zhang,5 Bin Yu2 1Drug Dispensing Department, The Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang, Sichuan, People’s ...
Wang M, Yu J, Xu H, Xu K, Sohail M, Wang J, Ning H, Zhang J, Yu B.   +8 more
europepmc   +3 more sources

Folic Acid Functionalized Diallyl Trisulfide-Solid Lipid Nanoparticles for Targeting Triple Negative Breast Cancer. [PDF]

Molecules, 2023
DATS (diallyl trisulfide), an anti-oxidant and cytotoxic chemical derived from the plant garlic, has been found to have potential therapeutic activity against triple-negative breast cancer (TNBC).
De A, Roychowdhury P, Bhuyan NR, Ko YT, Singh SK, Dua K, Kuppusamy G.   +6 more
europepmc   +3 more sources

Diallyl Trisulfide Causes Male Infertility with Oligoasthenoteratospermia in Sitotroga cerealella through the Ubiquitin-Proteasome Pathway. [PDF]

Cells, 2023
Essential oils extracted from plant sources along with their biologically active components may have negative effects on insects. Diallyl trisulfide (DAT) is an active component of garlic essential oil, and it exhibits multi-targeted activity against ...
Shah S, Elgizawy KK, Wu MY, Yao H, Yan WH, Li Y, Wang XP, Wu G, Yang FL.   +8 more
europepmc   +3 more sources

Diallyl trisulfide inhibits osteosarcoma 143B cell migration, invasion and EMT by inducing autophagy. [PDF]

Heliyon
Background: Diallyl trisulfide (DATS), a compound derived from garlic, has been demonstrated its anti-cancer properties. While it has been shown to inhibit the expression of epidermal growth factor receptor (EGFR) in various cancers, its effects on ...
Liu X, Wang N, He Z, Chen C, Ma J, Liu X, Deng S, Xie L.   +7 more
europepmc   +3 more sources

Antiviral activity of diallyl trisulfide against H9N2 avian influenza virus infection in vitro and in vivo [PDF]

Virology Journal, 2021
Background Diallyl trisulfide (DATS) is a garlic-derived organosulfur compound. As it has been shown to have anti-viral activity, we hypothesized that it may alleviate infections caused by H9N2 avian influenza virus (AIV), which is prevalent in poultry ...
Le Ming, Zhihui Li, Xiaofang Li, Ling Tang, Guimei He   +4 more
doaj   +2 more sources

Effects of garlic oil and diallyl trisulfide on glycemic control in diabetic rats

European Journal of Pharmacology, 2005
We investigated the effects of garlic oil and diallyl trisulfide on glycemic control in rats with streptozotocin-induced diabetes. Diabetic rats received by gavage garlic oil (100 mg/kg body weight), diallyl trisulfide (40 mg/kg body weight), or corn oil every other day for 3 weeks. Control rats received corn oil only.
Cheng-Tzu Liu, Lee-Yan Sheen
exaly   +4 more sources

Exploring the role and mechanisms of diallyl trisulfide and diallyl disulfide in chronic constriction-induced neuropathic pain in rats. [PDF]

Korean J Pain, 2020
Garlic oil is a rich source of organosulfur compounds including diallyl disulfide and diallyl trisulfide. There have been studies showing the neuroprotective actions of these organosulfur compounds. However, the potential of these organosulfur compounds in neuropathic pain has not been explored.
Wang G, Yang Y, Wang C, Huang J, Wang X, Liu Y, Wang H.   +6 more
europepmc   +4 more sources

Antiferroptotic properties of allicin and related organosulfur compounds—diallyl disulfide and diallyl trisulfide—from Garlic

Food and Chemical Toxicology
Allicin (diallyl thiosulfinate) is an abundant bioactive compound in garlic (Allium sativum L.) with broad-spectrum antiinflammatory, antifungal, antioxidant, and antitumor properties. The bioactive compounds of garlic including allicin may also help reduce the incidence of various diseases, although the individual contributions and precise mechanisms ...
Yoko Hirata, Haruna Nagase, Keitaro Satoh, Hiroshi Takemori, Kyoji Furuta, Yuji O. Kamatari   +5 more
openaire   +3 more sources

VALIDATION AND ANALYSIS OF DIALLYL DISULFIDE AND DIALLYL TRISULFIDE IN GARLIC (ALLIUM SATIVUM L.) USING GAS CHROMATOGRAPHY

International Journal of Applied Pharmaceutics, 2020
Objective: The purpose of this research was to optimize and validate a method for measuring the levels of diallyl disulfide (DADS) and diallyl trisulfide(DATS) in garlic and single clove garlic.Methods: The analysis was performed using gas chromatography (GC) equipped with an HP-1 column and a flame ionization detector.
HARMITA HARMITA, HERMAN SURYADI, LIDWINA DEVIANI LIKASA   +2 more
openaire   +4 more sources