Results 181 to 190 of about 3,935 (193)
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Effect of Diallyl Trisulfide on the Pharmacokinetics of Nifedipine in Rats
Journal of Food Science, 2011Abstract: This study aimed to evaluate the effect of diallyl trisulfide (DATS), a major component derived from garlic, on the pharmacokinetics of nifedipine. Pharmacokinetic parameters of nifedipine were determined in rats following an oral gavage (3 mg/kg) or intravenous administration (0.75 mg/kg) of ...
Yue, Wang +5 more
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Journal of Sulfur Chemistry, 2012
Accumulating pharmacological evidence has revealed that diallyl trisulfide (DATS) is uniquely active and its therapeutic effect prevails over diallyl disulfide (DADS). The cited reasons involve the bond dissociation energy, interconversion, lipophilicity, and polarizability of DATS.
Chiu-Lan Hsieh +5 more
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Accumulating pharmacological evidence has revealed that diallyl trisulfide (DATS) is uniquely active and its therapeutic effect prevails over diallyl disulfide (DADS). The cited reasons involve the bond dissociation energy, interconversion, lipophilicity, and polarizability of DATS.
Chiu-Lan Hsieh +5 more
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Naunyn-Schmiedeberg's Archives of Pharmacology, 2017
Sodium valproate (VP) is an important antiepileptic drug, although it can produce deleterious hepatotoxic reactions. Diallyl trisulfide (DATS) is the principle component of garlic oil that possesses antioxidant properties. This study explored the potential hepatoprotective activity of DATS against VP-induced hepatic damage and its underlying mechanisms.
Ahmed A, Shaaban, Dina S, El-Agamy
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Sodium valproate (VP) is an important antiepileptic drug, although it can produce deleterious hepatotoxic reactions. Diallyl trisulfide (DATS) is the principle component of garlic oil that possesses antioxidant properties. This study explored the potential hepatoprotective activity of DATS against VP-induced hepatic damage and its underlying mechanisms.
Ahmed A, Shaaban, Dina S, El-Agamy
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Anticancer effects of diallyl trisulfide derived from garlic.
Asia Pacific journal of clinical nutrition, 2008Alk(en)yl sulfides are characteristic flavor components of garlic. Several lines of epidemiological study indicate that the risk of a certain cancer can be prevented by consumption of garlic. In this manuscript, we examined the anticancer property of garlic-derived alk(en)yl sulfides, and the molecular basis especially for diallyl trisulfide which is a
Taiichiro, Seki +6 more
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Raman spectroscopic characteristics of diallyl trisulfide acting on trans‐crotonaldehyde
Journal of Raman Spectroscopy, 2015In this paper, the molecular mechanism of diallyl trisulfide (DATS) on trans‐crotonaldehyde (TCA) was studied by UV–vis absorption and Raman spectroscopies combining with density functional theory calculations. Experimental results indicate that the introduction of DATS can not only make the maximum absorption peak of TCA shift 15 nm, but also ...
Yanbin Su +5 more
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Preventive effect of Diallyl Trisulfide on cutaneous toxicities induced by EGFR inhibitor
International Immunopharmacology, 2019Cutaneous toxicities are the commonest side effects in patients with cancer treated using epidermal growth factor receptor inhibitors such as erlotinib. For patients with such toxicities, there is a lack of safe, effective pharmacological agents. Here we established a skin toxicity model and investigated the preventive and therapeutic effect of Diallyl
Yuping Liu +3 more
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Diallyl trisulfide suppresses the adipogenesis of 3T3-L1 preadipocytes through ERK activation
Food and Chemical Toxicology, 2012Garlic and its organosulfur compounds display hypolipidemic effects by inhibiting fatty acid and cholesterol synthesis. We investigated the anti-adipogenic effect of diallyl trisulfide (DATS), the second most abundant organosulfide in garlic oil. We studied the effects of DATS in 3T3-L1 preadipocytes and the mechanism involved in its action. DATS (0-75
Chong-Kuei, Lii +6 more
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Environmental Pollution, 2017
Benzene is a well-known occupational and environmental toxicant associated with cytopenia, which is characterized by a disorder in the peripheral blood cell counts. However, no effective preventive strategy has been developed yet to tackle the exposure to benzene in daily life.
Wenting, Han +6 more
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Benzene is a well-known occupational and environmental toxicant associated with cytopenia, which is characterized by a disorder in the peripheral blood cell counts. However, no effective preventive strategy has been developed yet to tackle the exposure to benzene in daily life.
Wenting, Han +6 more
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Phytomedicine, 2012
To elevate chemo-resistance of human cancer cells is a major obstacle in the treatment and management of malignant cancers. Diallyl sulfide (DAS), diallyl disulfide (DADS) and diallyl trisulfide (DATS) are presented in the Alliaceae family particularly in garlic.
Kuang-Chi, Lai +9 more
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To elevate chemo-resistance of human cancer cells is a major obstacle in the treatment and management of malignant cancers. Diallyl sulfide (DAS), diallyl disulfide (DADS) and diallyl trisulfide (DATS) are presented in the Alliaceae family particularly in garlic.
Kuang-Chi, Lai +9 more
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An oil-free microemulsion for intravenous delivery of diallyl trisulfide: Formulation and evaluation
International Journal of Pharmaceutics, 2011The aim of the present study was to develop an oil-free o/w microemulsion, Cremophor EL:ethanol-propylene glycol:saline, for diallyl trisulfide (DATS) for intravenous (i.v.) administration to modify the safety and pharmacokinetics of DATS. The ternary diagram was constructed to identify the regions of dilutable microemulsions, and the optimal ...
Xinru, Li +7 more
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