Results 101 to 110 of about 83,038 (344)

Switching the stereochemical outcome of 6-endo-trig cyclizations; Synthesis of 2,6-Cis-6-substituted 4-oxopipecolic acids [PDF]

, 2012
A base-mediated 6-endo-trig cyclization of readily accessible enone-derived α-amino acids has been developed for the direct synthesis of novel 2,6-cis-6- substituted-4-oxo-L-pipecolic acids. A range of aliphatic and aryl side chains were tolerated by
Agami C., Alastair A. Cant, Andrew Sutherland, Bernasconi R., Boger D. L., Cant A. A., Carbonnel S., Fowler L. S., Fowler L. S., Golubev A., Graham L. Simpson, Gutiérrez M. C., Hans Martin Senn, He M., Ireland R. E., Jatoi W. B., Johnson F., Jung J.-C., Kadouri-Puchot C., Lamarre D., Lindsay S. Fowler, Marin J., Mark Daly, Merino P., Occhiato E. G., Occhiato E. G., Purkayastha N., Purkayastha N., Romeo J. T., Romo D., Rudisill D. E., Schenk V. W., Smith A. B., Smith A. B., Smith A. B., Swindells D. C., Tanaka H., Vanderhaeghe H., Weigend F., Zacharius R. M., Zhao Y., Zhao Y.   +41 more
core   +1 more source

Total Asymmetric Synthesis of Glycomimetics and Polypropionates of Biological Interest

CHIMIA, 2008
Using readily available chiral auxiliaries such as (+)- and (?)-camphanic acid, (R,R)- and (S,S)-tartaric acid derivatives (e.g. RADO(R)-COCl, SADO(R)-COCl) efficient diastereoselective syntheses of rare sugars and glycomimetics have been ...
Pierre Vogel
doaj   +1 more source

Diastereoselection:  Introduction [PDF]

Chemical Reviews, 1999
B W, Gung, B, le Noble
openaire   +2 more sources

Hoch effiziente, präparative chromatographische Enantiomerentrennung von 2-Phenyl-1,3-dioxin-4-onen an Cellulose-triacetat und Cuprat-Additionen zu ?-Hydroxycarbonsäure-Derivaten

CHIMIA, 1991
The 2-Phenyl-dioxinones 1 and 2 are resolved on cellulose-triacetate columns (medium pressure, eluent MeOH, separation factors ? = 2.0–2.3, injection of g amounts).
Dieter Seebach, Urs Gysel, Joachim N. Kinkel   +2 more
doaj   +2 more sources

Towards the total synthesis of keramaphidin B

Beilstein Journal of Organic Chemistry, 2016
The enantio- and diastereoselective Michael addition of a δ-valerolactone-derived pronucleophile to a substituted furanyl nitroolefin catalysed by a bifunctional cinchonine-derived thiourea has been used as the key stereocontrolling step in a new ...
Pavol Jakubec, Alistair J. M. Farley, Darren J. Dixon   +2 more
doaj   +1 more source

Highly Efficient and Diastereoselective Synthesis of New Pyrazolylpyrrolizine and Pyrazolylpyrrolidine Derivates by a Three-Component Domino Process

Molecules, 2014
Diastereoselective reactions between 4-formylpyrazoles, N-substituted maleimides and glycine derivates led to new series of pyrazolyldipyrrolo [3,4-a:3',4'-f]pyrrolizines and pyrazolylpyrrolo[3,4-c]pyrroles in good yields.
Jairo Quiroga, Jaime Gálvez, Rodrigo Abonia, Braulio Insuasty, Alejandro Ortíz, Justo Cobo, Manuel Nogueras   +6 more
doaj   +1 more source

Total synthesis of (±)-paroxetine by diastereoconvergent cobalt-catalysed arylation

, 2014
A total synthesis of paroxetine is reported, with a diastereoselective and diastereoconvergent cobalt-catalysed sp3–sp2 coupling reaction involving a 3-substituted 4-bromo-N-Boc-piperidine (Boc = tert-butoxycarbonyl) substrate as a key step.
Despiau, Carole F., Dominey, Andrew P., Harrowven, David C., Linclau, Bruno   +3 more
core   +2 more sources

The synthesis of the 2,3-difluorobutan-1,4-diol diastereomers

Beilstein Journal of Organic Chemistry, 2017
The diastereoselective synthesis of fluorinated building blocks that contain chiral fluorine substituents is of interest. Here we describe optimisation efforts in the synthesis of anti-2,3-difluorobutane-1,4-diol, as well as the synthesis of the ...
Robert Szpera, Nadia Kovalenko, Kalaiselvi Natarajan, Nina Paillard, Bruno Linclau   +4 more
doaj   +1 more source

One-pot multi-reaction processes: synthesis of natural products and drug-like scaffolds [PDF]

, 2014
One-pot multi-reaction processes involving Overman rearrangements, metathesis cyclizations, and Diels–Alder reactions have been developed for the rapid and efficient synthesis of amino-substituted carbocyclic and heterocyclic compounds.
Calder, Ewen D.D., Grafton, Mark W., Sutherland, Andrew   +2 more
core   +1 more source

Ligand-enabled Ir-catalyzed intermolecular diastereoselective and enantioselective allylic alkylation of 3-substituted indoles

Chemical Science, 2015
A ligand-enabled Ir-catalyzed diastereoselective and enantioselective allylic alkylation of 3-substituted indoles is reported, providing indoline products containing three contiguous stereocenters in one step with high site-, regio-, diastereo- and ...
Xiao Zhang, Wen-Bo Liu, Hang-Fei Tu, S. You   +3 more
semanticscholar   +1 more source