Results 121 to 130 of about 23,776 (268)
Enantio-, atrop-, and diastereoselective macrolactonization to access type III cyclophanes
Nature CommunicationsAlthough chiral substituents have been incorporated into ansa chains to stabilize the conformations of cyclophanes and modulate the biological activities of pharmaceuticals, the asymmetric syntheses of these atropisomers relies on substrate-induced ...
Jiaming Wang +4 more
doaj +1 more source
Diastereoselectivity in Photochemistry
International audience ; Diastereoselective photochemical reactions play an important role for asymmetric synthesis, for example for the synthesis of natural or biologically active compounds. Chirality is either induced by a chiral auxiliary or by a chiral centers already present in the substrates.
openaire +2 more sources
Total Synthesis of Sacrolide A and Cytotoxic Evaluation
European Journal of Organic Chemistry, EarlyView.Isolated from the edible cyanobacterium Aphanothece sacrum, sacrolide A is a highly potent antimicrobial and cytotoxic metabolite. Its total synthesis via a convergent strategy enabled accurate assessment of its effects on liver and colon cells, offering new insights into its bioactivity and potential health risks.
Priyanka Kataria +7 more
wiley +1 more source
, 2019 A diastereoselective Co2(CO)8-mediated Pauson-Khand reaction (PKR) of siloxy-tethered 1,7-enynes for the synthesis of cyclopentaoxasilinones has been developed.
Daniel M., Lange +10 more
core +1 more source
Epoxidation of Cashmeran and Unprecedented Rearrangement to an α‐Carbonyl δ‐Spirolactone
European Journal of Organic Chemistry, EarlyView.A new strategy enables diastereoselective conversion of Cashmeran into a previously unknown α‐carbonyl δ‐spirolactone via epoxidation, Baeyer–Villiger oxidation, and acid‐catalyzed rearrangement. Structure and mechanism were confirmed by NMR, single crystal X‐ray diffraction, and computational studies. We report the epoxidation of Cashmeran followed by
Lukas Kell +7 more
wiley +1 more source
Unsaturated biobased polyesters from bicyclic α‐pinene‐based diols
Polymer International, EarlyView.We present the synthesis of four biosourced unsaturated polyesters made from chiral terpene‐based diols and esters of renewable diacids. The resulting materials harbor a bicyclic pinene ring in their backbones which leads to enhanced thermal properties while still conferring susceptibility to enzyme hydrolysis for chains having a cis alkene.
Ganapathy Ranjani +4 more
wiley +1 more source
Diastereoselective sulfoximine inhibition of carboxypeptidase A.
, 1991 Diastereoselective sulfoximine inhibition of carboxypeptidase ...
Zuowu (Joyce). Zhang (7960370)
core
The Chemical Record, EarlyView.This review highlights recent advances in the use of organic carbonates, dimethyl carbonate (DMC), diethyl carbonate (DEC), and propylene carbonate (PC), as solvents in organic synthesis. Based on over seventy studies from the past 6 years, it shows their application in different organic reaction types, emphasizing their role in safer and more ...
Gabriela T. Quadros +5 more
wiley +1 more source
Chiral (Stereoselective) Drugs, Asymmetric Synthesis, and Racemic Resolution Methods
Chirality, Volume 38, Issue 7, July 2026.Chirality is crucial in drug development since both biological targets in the organism and the majority of pharmaceutical compounds are chiral. The synthesis and resolution of chiral compounds are critical steps while developing chiral drugs. Asymmetric synthesis and racemic resolution are the two most common methods for obtaining enantiopure drugs ...
Burcu Karayavuz +1 more
wiley +1 more source
, 2018 Diastereoselective fluorination of N-Boc (R)- and (S)-2,2-dimethyl-4-((arylsulfonyl)methyl)oxazolidines and a previously unknown diastereoselective epimerization at the fluorine-bearing carbon atom α to the sulfone was realized.
Barbara Zajc (1923484) +6 more
core +1 more source