Results 121 to 130 of about 6,473 (220)

Decarboxylative alkylation of alkenes. [PDF]

Nature
Roy TK, Tamborini FM, Petzold R, Fu J, Tang Y, Ritter T.   +5 more
europepmc   +1 more source

Reenvisioning the De Mayo Reaction: A Boron‐Enabled Cycloaddition Approach

Angewandte Chemie, Volume 138, Issue 29, 13 July 2026.
An oxa‐boracycle conformational lock strategy enables photocatalytic [2+2] cycloaddition to afford densely substituted cyclobutylboronates. The conformational constraint suppresses triplet relaxation and promotes productive bimolecular reactivity.
Neetu Sharma, Yanyao Liu, Partha Sarathi Hazra, Evan B. Piper, Ryan Van Hoveln, Michael Kevin Brown   +5 more
wiley   +2 more sources

K⁺/Cu²⁺ Co-chelated diastereoselective Friedel-Crafts reaction with chiral <i>N</i>-sulfinyl ketimines for the facile synthesis of chiral bisindoles and their cytotoxicity. [PDF]

RSC Adv
Yan S, Xu M, Liu Y, Du Z, Zhang G, Liu Z, Xiao J, Guo X, Liao G, Min Q, Xie B, Qin S.   +11 more
europepmc   +1 more source

Recent Advances in Intramolecular C─N Bond Formation for Pyrrolidine Synthesis. [PDF]

ChemistryOpen
Kroņkalne R, Turks M.
europepmc   +1 more source

Synthesis of Benzopyran Atropisomers via Electrophilic Halogenation

European Journal of Organic Chemistry, Volume 29, Issue 27, 17 July 2026.
We report a halogenation‐based method for the synthesis of axially chiral benzopyrans, tolerating diverse substituents and halogens (Br, Cl, and I). A double bromination gives bisbenzopyrans with two stereogenic axes. Preliminary enantioselective conditions yield benzopyran atropisomer with up to 56% ee.
Alix Bourhis, Expédite Yen‐Pon, Jean Rodriguez, Damien Bonne   +3 more
wiley   +1 more source

One-pot multicomponent diastereoselective synthesis of indoline spirobicyclics using a recyclable chiral nanomagnetic L-proline catalyst under mild conditions. [PDF]

Sci Rep
Rafipour D, Sardarian AR, Jamali M, Davoodi S.   +3 more
europepmc   +1 more source

Total Synthesis of Sacrolide A and Cytotoxic Evaluation

European Journal of Organic Chemistry, Volume 29, Issue 27, 17 July 2026.
Isolated from the edible cyanobacterium Aphanothece sacrum, sacrolide A is a highly potent antimicrobial and cytotoxic metabolite. Its total synthesis via a convergent strategy enabled accurate assessment of its effects on liver and colon cells, offering new insights into its bioactivity and potential health risks.
Priyanka Kataria, Kamel Hadj‐Kaddour, Alexis Giraudon, Jawad Belkheir, Alexandre Guy, Thierry Durand, Magali Gary‐Bobo, Camille Oger   +7 more
wiley   +1 more source

NaHMDS/B(C₆F₅)₃-promoted diastereoselective Friedel-Crafts alkylation of indoles/pyrroles with <i>N-tert</i>-butanesulfinylimines: towards the asymmetric synthesis of bisindole alkaloid Calcicamide B. [PDF]

RSC Adv
Zhang G, Chen X, Liu Y, Peng R, Xu M, Yan S, Xiao J, Liu Z, Min Q, Liao G, Wang X, Qin S.   +11 more
europepmc   +1 more source

Fluorinated Aminopiperidones as Non‐Glutarimide Thalidomide Analogs: Stereodivergent Synthesis and Validation

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Fluorinated aminopiperidones, designed as non‐glutarimide thalidomide analogs, were synthesized with full regio‐ and stereocontrol. The C*–CF3 used as carbonyl surrogate improved solubility and membrane interactions while abolishing cereblon binding.
Boštjan Adamlje, Tihomir Tomašič, Christian Steinebach, Sebastian Ebeling, Alexander Herrmann, Marcus D. Hartmann, Jessica L. Horner, Kinjal Bhadresha, Cindy H. Chau, William D. Figg, Izidor Sosič, Andrej Emanuel Cotman   +11 more
wiley   +1 more source

Diastereoselective synthesis of novel (S)-lactic pyrazoline derivatives and investigation of antibacterial capabilities. [PDF]

Sci Rep
Gholami M, Imanzadeh G, Kabiri Esfahani F, Karami-Zarandi M, Shamkhali AN.   +4 more
europepmc   +1 more source