Results 141 to 150 of about 26,606 (255)

Nickel/Photoredox-catalyzed diastereoselective semihydrogenation of alkynes using a carboxylic acid as a cooperative ligand and hydrogen surrogate. [PDF]

Nat Commun
Zhang J, Zhang N, Sun W, Jie M, Pan Z, Xia C.   +5 more
europepmc   +1 more source

Toward the Synthesis of Pestalustaine A: Structural Revision and Formation of Original Strained Tricyclic Architectures

Angewandte Chemie, Volume 138, Issue 37, 7 September 2026.
Our synthetic endeavor toward the total synthesis of the reported unprecedented tricyclic skeleton of the sesquiterpene pestalustaine A allowed us to perform divergent cyclizations of a bicyclo[4.4.1]undec‐3‐ene into complex tricyclic architectures and to revise the structure of the natural product.
Wei Cao, Alicia Ross, Jean‐Pierre Baltaze, Régis Guillot, Menglin Xu, Rongzhen Qin, Bingcheng Yang, Isabel Wong, Katayoon Formul, Cyrille Kouklovsky, Dean J. Tantillo, Vincent Gandon, Guillaume Vincent   +12 more
wiley   +2 more sources

Next‐Generation Manufacturing: The Evolving Role of Biocatalysis in AstraZeneca

ChemBioChem, Volume 27, Issue 17, 14 September 2026.
Biocatalysis is strengthening AstraZeneca's manufacture of active pharmaceutical ingredients through faster development, robust scale‐up, and lower environmental impact. Case studies illustrate where biocatalysis delivers greatest value, while enabling platforms, teams, and partnerships shape its next phase.
Alba Diaz‐Rodriguez, Martin A. Hayes, Keith R. Mulholland, Fernando Tur, Samantha Staniland   +4 more
wiley   +1 more source

Photochemical Ring Opening of Cyclopropyl Silyl Ethers Enables β–β Coupling, Radical‐Polar Crossover and Annulation

Angewandte Chemie, Volume 138, Issue 37, 7 September 2026.
A photochemical platform enables β–β coupling of cyclopropyl silyl ethers with electron‐deficient alkenes. The resulting adducts serve as entry points into annulative and radical–polar crossover pathways, providing rapid access to fused, bridged, and spirocyclic architectures, including late‐stage scaffold diversification to diterpene‐like carbocyclic ...
Jacop Rydén, Eilidh Young, Wilma Olsson, Eskil Flodén, Mattias Tan, Sebastian Clementson   +5 more
wiley   +2 more sources

Diastereoselective synthesis of spiro[2.<i>n</i>]alkanes <i>via</i> intramolecular carbolithiation. [PDF]

Chem Sci
Teschers CS, Barra C, Scherübl M, Zuber J, Marek I.   +4 more
europepmc   +1 more source

Synthesis and Evaluation of Peptoid‐Based Compound Libraries as Inhibitors of Parasite Metallo‐Aminopeptidases

ChemMedChem, Volume 21, Issue 17, 14 September 2026.
Evaluation of two libraries of peptoid‐based compounds for inhibitory activity against PfA‐M1 from Plasmodium falciparum, TcLAP from Trypanosoma cruzi, and LmLAP from Leishmania major reveals the crucial role of hydrophobic interactions in the inhibition process of these parasite metallo‐aminopeptidases.
Mirta Elisa Aguado, Gerardo M. Ojeda‐Carralero, Mario Antonio Rodríguez, Isabella Rúa, Heisy Guerra, Edoardo Bailo Hernández, Guglielmo Coppola, Susana Alberti, Ariatne Rodríguez, Maikel Izquierdo, Christian Betzel, Filippo Pettazzi, Julieta Coro‐Bermello, Erik V. Van der Eycken, Bernhard Westermann, Jorge González‐Bacerio, Daniel G. Rivera   +16 more
wiley   +1 more source

Asymmetric Total Synthesis of C2-OH Lycopodium Alkaloids (-)-Palhinine B, (-)-Palhinine C, and (+)-Palhinine B Enabled by Stereocontrolled Diels-Alder Strategy. [PDF]

Org Lett
Pantawane A, Chen CM, Kuo TC, Reddy JS, Cheng MJ, Luo SY, Hsieh HP.   +6 more
europepmc   +1 more source

Catalytic Generation of Cationic Gold Carbene Complexes From 7‐Alkynylnorbornadienes and Their Intermolecular Cyclopropanation With Alkenes

Chemistry – A European Journal, Volume 32, Issue 34, 11 September 2026.
Efficient cationic gold(I)‐catalyzed intermolecular cyclopropanation of 7‐alkynylnorbornadiene derivatives has been developed. This methodology offers the synthesis of a new class of norbornene derivatives in high yield with excellent diastereoselectivity.
Kento Ishida, Kenta Toei, Fumiaki Tomi, Norio Sakai   +3 more
wiley   +1 more source

A General and Scalable Chiral Surrogate Rotaxane Strategy for Highly Enantioenriched Mechanically Planar Chiral Rotaxanes. [PDF]

Angew Chem Int Ed Engl
Lee SR, Liu YH, Chiu SH.
europepmc   +1 more source

Covalent Insertion of a Mn(Salen) Type Complex in Cross‐Linked Protein Crystals: Design of an Enantioselective Artificial Epoxidase

Chemistry – A European Journal, Volume 32, Issue 34, 11 September 2026.
An Artificial metalloenzyme was designed by a Michael addition between a MnSalen complex and a cysteine residue within NikA crystals. The heterogeneous catalyst was found capable of an enantioselective and stereospecific epoxidation of cis‐β‐methylstyrene in cristallo.
Manel Boukhallat, Ismail Benhamed, Jade Arnone, Stann Van Baaren, Clara Rinaldi, Patrice Catty, Caroline Marchi‐Delapierre, Christine Cavazza, Stéphane Ménage   +8 more
wiley   +1 more source