Results 161 to 170 of about 23,776 (268)

Smiles/Pudovik/Phospha–Brook Cascades from Passerini–Smiles Adducts

ChemistryEurope, Volume 4, Issue 6, June 2026.
The Passerini–Smiles reaction of aliphatic ketophosphonates affords starting materials for complex cascades triggered by a first Smiles rearrangement. The cascade showcases the power of phosphorous based transformations. Here the reversibility of the Pudovik reaction allows a further Truce–Smiles reaction enol before final Pudovik/Phosph–Brook sequence.
Cristina Cheibas, Nicolas Casaretto, Laurent El Kaim   +2 more
wiley   +1 more source

K⁺/Cu²⁺ Co-chelated diastereoselective Friedel-Crafts reaction with chiral <i>N</i>-sulfinyl ketimines for the facile synthesis of chiral bisindoles and their cytotoxicity. [PDF]

RSC Adv
Yan S, Xu M, Liu Y, Du Z, Zhang G, Liu Z, Xiao J, Guo X, Liao G, Min Q, Xie B, Qin S.   +11 more
europepmc   +1 more source

Selective Rh(II)‐Catalyzed Intermolecular Oxyamidation and Acid‐Promoted Nucleophilic Cyclization Cascade of Enamides

ChemistryEurope, Volume 4, Issue 6, June 2026.
A structurally diverse series of 1‐amino‐izidine scaffolds was accessed through a cascade process combining rhodium‐catalyzed nitrene‐transfer oxyamidation with subsequent nucleophilic cyclization under acidic conditions, proceeding via an in situ generated iminium intermediate.
Grégory Jestin, Romain Rey‐Rodriguez, Romane Manguin, Pascal Retailleau, Philippe Dauban, Isabelle Gillaizeau   +5 more
wiley   +1 more source

Non-chelation control in allylations of α-oxy ketones using group-14 allylatranes. [PDF]

Nat Commun
Tsutsui Y, Shiga K, Konishi A, Yasuda M.
europepmc   +1 more source

Decarboxylative alkylation of alkenes. [PDF]

Nature
Roy TK, Tamborini FM, Petzold R, Fu J, Tang Y, Ritter T.   +5 more
europepmc   +1 more source

Structural‐to‐Functional Complexity Transformations Enabled by Bridged Polyheterocycles: Access to Cis‐1,3‐Diamines and Amino‐Alcohols

ChemistryEurope, Volume 4, Issue 6, June 2026.
Polycyclic intermediates enable stereocontrolled synthesis of densely functionalized cis‐1,3‐diamine and amino alcohol carbocycles and heterocycles via structural‐to‐functional complexity transformations from low‐complexity starting material. Cis‐1,3‐functionalized carbocycles and saturated heterocycles are ubiquitous motifs in natural products ...
Jiayi Zhu, Erica Benedetti, Laurent Micouin   +2 more
wiley   +1 more source

Iridium-Catalyzed Stereoselective α-Alkylation of α-Hydroxy Ketones with Minimally Polarized Alkenes. [PDF]

J Am Chem Soc
Wang Y, Hong F, Robertson CM, Mudd RJ, Bower JF.   +4 more
europepmc   +1 more source

Dihydroquinazolinones by Titanocene‐Catalyzed Reductive Radical Addition to Quinazolinones

Chemistry – A European Journal, Volume 32, Issue 21, 1 June 2026.
Tri‐ and tetracyclic dihydroquinazolinones or quinazolinones by titanocene catalysis: A highly diastereoselective and efficient reductive radical addition to quinazolinones enables an unprecedented entry to pharmaceutically relevant dihydroquinazolinones by avoiding the interception of radical intermediates prior to the slow radical addition.
Thomas Heinrichs, Fabian Lang, Konstantin Woitol, Jana Vohn, Andreas Schneider, Andreas Gansäuer   +5 more
wiley   +1 more source

ProTides for Antiviral Activity Beyond Liver Cells

Chemistry – A European Journal, Volume 32, Issue 21, 1 June 2026.
A strategy for obtaining prodrugs of antiviral nucleotides with broad tissue activity is presented that relies on cycloalkyl or cycloalkylalkyl esters, improving uptake and esterase cleavage, and producing nanomolar inhibitors in kidney, colon, and lung cells.
Felix Goebel, Adrian Humboldt, Heeyoung Kim, Carl J. M. Schölzel, Ralf Bartenschlager, Clemens Richert   +5 more
wiley   +1 more source

One-pot multicomponent diastereoselective synthesis of indoline spirobicyclics using a recyclable chiral nanomagnetic L-proline catalyst under mild conditions. [PDF]

Sci Rep
Rafipour D, Sardarian AR, Jamali M, Davoodi S.   +3 more
europepmc   +1 more source