Results 111 to 120 of about 26,606 (255)

Rhodium‐Catalyzed Synthesis of Enantioenriched α‐Substituted Primary Amines Through Asymmetric Transfer Hydrogenation

Chemistry – A European Journal, EarlyView.
Enantioenriched α‐substituted primary amines are efficiently prepared by rhodium‐catalyzed asymmetric transfer hydrogenation of ortho‐hydroxyaryl N─H imines under mild conditions using a low catalyst loading and ammonium formate as the hydrogen source in high yields (up to 99%) and enantioselectivities (up to 99% ee).
Chonghuo Liu, Guillaume Lefèvre, Qin Yin, Phannarath Phansavath, Virginie Ratovelomanana‐Vidal   +4 more
wiley   +1 more source

Enabling Cross‐Coupling Reactivity of α‐Pentafluorosulfanyl Compounds with a Thermally Stable Organozinc α‐SF5 Reagent

Chemistry – A European Journal, EarlyView.
This work describes the first example of a thermally stable α‐SF5 organometallic reagent, which allows for extensive downstream functionalization by allylation and acylation reactions under copper catalysis, as well as palladium‐catalyzed Negishi‐type cross‐coupling conditions up to 96% yield. In silico analysis shines initial light on the requirements
Lujie Xu, David Rombach
wiley   +1 more source

Enantio-, atrop-, and diastereoselective macrolactonization to access type III cyclophanes

Nature Communications
Although chiral substituents have been incorporated into ansa chains to stabilize the conformations of cyclophanes and modulate the biological activities of pharmaceuticals, the asymmetric syntheses of these atropisomers relies on substrate-induced ...
Jiaming Wang, Kang Lv, Yilu Wen, Tao Liu, Changgui Zhao   +4 more
doaj   +1 more source

Access to Uncharted (Ethoxy)difluoromethylated‐Containing Tetrahydrofurans by Hydrogenation

Chemistry – A European Journal, EarlyView.
A Pd/C‐catalyzed selective hydrogenation of (ethoxy)difluoromethylated‐containing tetrahydrofurans was achieved. Depending on the pressure of H2, a divergent process led to either cis CF2CO2Et‐containing tetrahydrofurans or valuable α,α‐difluoro‐β‐hydroxyesters, offering key fluorinated building blocks for drug discovery while keeping the CF2CO2Et ...
Thibaud Charvillat, Victor Levet, Patrick Bernardelli, Marc Daumas, Hassan Oulyadi, Muriel Sebban, Vincent Ferey, Tatiana Besset   +7 more
wiley   +1 more source

Diastereoselectivity in Photochemistry

International audience ; Diastereoselective photochemical reactions play an important role for asymmetric synthesis, for example for the synthesis of natural or biologically active compounds. Chirality is either induced by a chiral auxiliary or by a chiral centers already present in the substrates.
openaire   +2 more sources

One-Pot Highly Diastereoselective Synthesis of cis-Vinylaziridines via the Sulfur Ylide-Mediated Aziridination and Palladium(0)-Catalyzed Isomerization

, 2010
Highly diastereoselective synthesis of cis-trisubstituted vinylaziridines containing a quaternary carbon center is realized by a one-pot protocol in which the combination of sulfur ylide-mediated aziridination of cyclic ketimines and Pd(0)-catalyzed ...
Zheng, Jun-Cheng, Tang, Yong, Sun, Xiu-Li, Zhu, Ben-Hu, Zhou, Yong-Gui, Yu, Chang-Bin, Shen, Qi, 周永贵   +7 more
core   +1 more source

Diastereoselective Synthesis of Iminosugars using g-Siloxyallyltins

, 2005
Communication par affiche intitulée (présentée par J.-P.
Beaudet, I., Le Grognec, E., Chevallier, J.F., Quintard, J.-P.   +3 more
core   +4 more sources

Synthetic Strategies for the Construction of Cyclobutane‐Fused Heterocycles

European Journal of Organic Chemistry, EarlyView.
Cyclobutane‐fused heterocycles are important motifs commonly present in bioactive compounds, recognized for their rigid 3D structures that confer unique properties. However, synthesizing these compounds remains challenging. This review discusses current methods for their synthesis, such as photochemical, metal‐catalyzed, and Lewis acid‐mediated [2 + 2]
Michela Vargiu, Mauro Uras, Angelo Frongia   +2 more
wiley   +1 more source

The Expanding Role of Diazirines in Synthetic Methodology

European Journal of Organic Chemistry, EarlyView.
Beyond their established role in photoaffinity labeling, diazirines have emerged as versatile reagents in synthetic chemistry. This review highlights their dual reactivity as carbene and nitrogen‐transfer precursors, showcasing mechanistic insights and diverse applications in cyclopropanations, cycloadditions, skeletal editing, amination, heterocycle ...
Viktor Savic, Dominik Schnalzer, Marko D. Mihovilovic, Michael Schnürch   +3 more
wiley   +1 more source

Diastereoselective synthesis of non‐proteinogenic α‐amino acids

, 2008
International audienceThe synthesis of enantiomerically pure azatyrosine, tribromophenylalanine and trichlorophenylalanine is described, using two methods, diastereoselective alkylation and (or) diastereoselective protonation of chiral ...
Viallefont, P.H., Rolland, Valérie, Pappalardo, L., Martinez, Jean, Roumestant, M.L., Lecointe, L.   +5 more
core   +1 more source