Results 111 to 120 of about 23,776 (268)
Highly diastereoselective silyl-modified Sakurai multicomponent reaction
, 2006 Highly diastereoselective silyl-modified Sakurai multicomponent ...
Marko, Istvan +5 more
core +1 more source
Chinese Journal of Chemistry, EarlyView.Under copper(I) catalysis, pentafluoroethylated alkenes can undergo smooth defluorosilylation to generate novel polyfluorinated products. The reaction exhibits high levels of diastereoselectivities for obtaining multisubstituted allylsilanes with control of the double bond geometry.
Yuwei Zong, Yihan Tang, Gavin Chit Tsui
wiley +1 more source
Diastereoselective Synthesis of β-Hydroxyketones
Natural Product Communications, 2008 The diastereoselective synthesis of 2,4-dibromo-3-hydroxy-1,3-diphenylbutan-1-one [ 4 ( a-a’ )]; 2,4-dibromo-3-hydroxy-1,3-di [( p -chloro)phenyl]butan-1-one [ 5 ( a-a’ )] and 2,4-dibromo-3-hydroxy-1,3-di[( p -phenyl)phenyl]butan-1-one [ 6(a-a’) ] using (
Teresa Mancilla Percino +2 more
doaj +1 more source
European Journal of Organic Chemistry, EarlyView.The intramolecular nitrile oxide olefin [3 + 2]‐cycloaddition offers a reliable entry toward 2‐aza‐bicyclo[4.3.0]‐nonanes, a substructure found in several bioactive piperidine alkaloids. The required oxime precursors were prepared in non‐racemic form by Ir‐catalyzed asymmetric allylation and ring‐closing metathesis.
Alicia Köcher +5 more
wiley +1 more source
Selective Synthesis of Functionalized, Tertiary Silanes by Diastereoselective Rearrangement−Addition
, 2016 Treatment of hydroxy-substituted silyl epoxides with Grignard reagents induces a 1,2-carbon shift to reveal α-silyl aldehydes, which are trapped by highly diastereoselective addition reactions of the Grignard reagent.
Zachary T. Ball (1819597) +2 more
core +1 more source
European Journal of Organic Chemistry, EarlyView.Chiral tri‐ and pentahydroxy spirocyclopentane‐indolizidines were synthesized using lithium diisopropylamide “LDA” promoted diallylation and tetrahydrofuran “THF” ring‐opening in a one‐pot procedure as a key step. The sequence leading to the targeted hydroxy‐spiroindolizidines was achieved by cis‐dihydroxylation followed by reduction of the enamine and
Paula Fraňová +6 more
wiley +1 more source
European Journal of Organic Chemistry, EarlyView.Effective synthesis of 3‐substituted isoindolinones is possible through novel cascade reactions of alkyl arylacetates with 2‐cyanobenzaldehydes under mild, basic conditions. Herein we report the use of alkyl arylacetates as pro‐nucleophiles in cascade reactions with 2‐cyanobenzaldehydes leading to the formation of novel 3‐substituted isoindolinones, a ...
Antonia Di Mola +4 more
wiley +1 more source
Diastereoselective Synthesis of the Hydroperoxide–Keto Form of (±)-Steenkrotin B
, 2018 A diastereoselective approach for the synthesis of the hydroperoxide–keto form of (±)-steenkrotin B (2′) is described. The key features of the strategy involve a Diels–Alder cycloaddition, a titanium(III)-catalyzed reductive annulation, and a regio- and
Hanfeng Ding (1743382) +7 more
core +1 more source
A Short Total Synthesis of the Daucane Sesquiterpenoid Ferutinin
European Journal of Organic Chemistry, EarlyView.Only nine steps were required to access the bioactive daucane sesquiterpene ester ferutinin (1) from 3‐methyl‐2‐cyclopentenone (3) and allyl p‐tolyl sulfoxide. A one‐pot 1,4‐addition/aldol sequence was used to rapidly provide diene 2 (TBS = tert‐butyldimethylsilyl), ring‐closing metathesis of which followed by alkylation and acylation gave rise to the ...
Christiane Osthaar +3 more
wiley +1 more source
Synthesis of Benzopyran Atropisomers via Electrophilic Halogenation
European Journal of Organic Chemistry, EarlyView.We report a halogenation‐based method for the synthesis of axially chiral benzopyrans, tolerating diverse substituents and halogens (Br, Cl, and I). A double bromination gives bisbenzopyrans with two stereogenic axes. Preliminary enantioselective conditions yield benzopyran atropisomer with up to 56% ee.
Alix Bourhis +3 more
wiley +1 more source