Catalytic Enantioselective Intramolecular Aza‐Michael Addition to α,β‐Unsaturated Esters
Angewandte Chemie, Volume 138, Issue 30, 20 July 2026.A general method for accessing enantioenriched saturated N‐heterocycles via a catalytic enantioselective intramolecular aza‐Michael reaction to α,β‐unsaturated esters is described. A superbasic bifunctional iminophosphorane (BIMP) catalyst was key to enabling reactivity of the high pKa sulfonamide pronucleophile, whilst delivering good to excellent ...
Evan G. W. Rutter +5 more
wiley +2 more sources
Diastereodivergent electrophilic trapping of α-boryl lithium derivatives. [PDF]
Beilstein J Org ChemPavlíčková T, Orbach N, Marek I.
europepmc +1 more source
A Chiral Saddle‐Shaped Nanographene With Two Heptagon‐Embedded [4]Helicenes
Angewandte Chemie International Edition, Volume 65, Issue 31, 27 July 2026.We present a novel synthetic strategy toward a chiral saddle‐shaped nanographene (cSNG) via a two‐step oxidation of a prochiral anthracene precursor. The Scholl‐type oxidation first yields a key intermediate with sp3‐defect heptagons, and subsequent oxidative dehydrogenation affords fully conjugated cSNG.
Felix Trautner +11 more
wiley +1 more source
Highly Cα-regio-, enantio- and diastereoselective Mukaiyama-type annulation of siloxyfurans: stereodivergent synthesis of multi-stereogenic tricyclic γ-lactones. [PDF]
Chem SciGan L +14 more
europepmc +1 more source
Asymmetric Total Synthesis of (-)-Verrucarol. [PDF]
Angew Chem Int Ed EnglPowers MH +5 more
europepmc +1 more source
Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview
Chemistry – A European Journal, Volume 32, Issue 28, 25 July 2026.The graphical abstract summarizes the review “Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview”, highlighting representative Pd(II)‐catalyzed methods for the β‐arylation of α‐amino acids. Key mechanistic features, substrate diversity, and synthetic relevance of these transformations are showcased. Abstract Metal‐catalyzed C─
Davide Illuminati +4 more
wiley +1 more source
Non-chelation control in allylations of α-oxy ketones using group-14 allylatranes. [PDF]
Nat CommunTsutsui Y, Shiga K, Konishi A, Yasuda M.
europepmc +1 more source
Pharmaceuticals Made with Hydrogen: A Sustainable and Efficient Approach Using Flow Synthesis
Chemistry – A European Journal, Volume 32, Issue 28, 25 July 2026.We demonstrate a sustainable strategy for pharmaceutical manufacturing by combining hydrogen, heterogeneous catalysis, and continuous flow synthesis. The development of novel catalysts and their application in a multi‐step synthesis of donepezil enabled a highly productive process with no intermediate purification.
Shū Kobayashi, Haruro Ishitani
wiley +1 more source
Iridium-Catalyzed Stereoselective α-Alkylation of α-Hydroxy Ketones with Minimally Polarized Alkenes. [PDF]
J Am Chem SocWang Y +4 more
europepmc +1 more source
Epoxidation of Cashmeran and Unprecedented Rearrangement to an α‐Carbonyl δ‐Spirolactone
European Journal of Organic Chemistry, Volume 29, Issue 28, 25 July 2026.A new strategy enables diastereoselective conversion of Cashmeran into a previously unknown α‐carbonyl δ‐spirolactone via epoxidation, Baeyer–Villiger oxidation, and acid‐catalyzed rearrangement. Structure and mechanism were confirmed by NMR, single crystal X‐ray diffraction, and computational studies. We report the epoxidation of Cashmeran followed by
Lukas Kell +7 more
wiley +1 more source