Results 71 to 80 of about 83,038 (344)

A diastereoselective approach to axially chiral biaryls via electrochemically enabled cyclization cascade

Beilstein Journal of Organic Chemistry, 2019
A diastereoselective approach to axially chiral imidazopyridine-containing biaryls has been developed. The reactions proceed through a radical cyclization cascade to construct the biaryls with good to excellent central-to-axial chirality transfer.
Hong Yan, Zhong-Yi Mao, Zhong-Wei Hou, Jinshuai Song, Hai-Chao Xu   +4 more
doaj   +1 more source

Stereoselective gridization and polygridization with centrosymmetric molecular packing

Nature Communications, 2020
Gridarenes with well-defined edges and vertices represent versatile nanoscale building blocks for installating frameworks but suffer from lack of stereoselective control during their synthesis. Here, the authors report a diastereoselective gridization of
Dongqing Lin, Ying Wei, Aizhong Peng, He Zhang, Chunxiao Zhong, Dan Lu, Hao Zhang, Xiangping Zheng, Lei Yang, Quanyou Feng, Linghai Xie, Wei Huang   +11 more
doaj   +1 more source

Fluorine‐Directed Diastereoselective Iodocyclizations

Angewandte Chemie International Edition, 2007
An inside job: β‐Fluorinated lactones and tetrahydrofurans are synthesized by iodocyclization of various allylic fluorides. The fluorine substituent acts as a highly efficient syn‐stereodirecting group for the ring closure. The experimental results combined with theoretical studies provide evidence in support of an “inside fluoro effect” to account for
Tredwell, M, Luft, J, Schuler, M, Tenza, K, Houk, K, Gouverneur, V   +5 more
openaire   +2 more sources

Organocatalytic enantio- and diastereoselective cycloetherification via dynamic kinetic resolution of chiral cyanohydrins

Nature Communications, 2017
Enantioselective synthesis of six-membered oxacycles with multiple stereogenic centres is essential for the discovery of new therapeutic agents. Here the authors show organocatalytic cycloetherification for the highly enantio- and diastereoselective ...
Naoki Yoneda, Yuki Fujii, Akira Matsumoto, Keisuke Asano, Seijiro Matsubara   +4 more
doaj   +1 more source

Diastereoselective desymmetric 1,2-cis-glycosylation of meso-diols via chirality transfer from a glycosyl donor

Nature Communications, 2020
Enzyme-catalyzed desymmetric glycosylations are often found in nature, however the corresponding chemical methods are lacking. Here, the authors report a highly diastereoselective desymmetric 1,2-cis-glycosylation of meso-diols found in myo-inositol 1,3 ...
Masamichi Tanaka, Koji Sato, Ryoki Yoshida, Nobuya Nishi, Rikuto Oyamada, Kazuki Inaba, Daisuke Takahashi, Kazunobu Toshima   +7 more
doaj   +1 more source

Stereoselective Synthesis of Euscapholide and Tetraketide via Prins Cyclisation and Ring-Closing Metathesis

SynOpen, 2022
A concise and diastereoselective total synthesis of tetraketide and euscapholide is described in ten steps in 10.6% overall yield from acetaldehyde and (S)-pent-4-ene-1,2-diol.
Dhanraj O. Biradar, Yogesh D. Mane, Basi V. Subba Reddy   +2 more
doaj   +1 more source

Synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations

Beilstein Journal of Organic Chemistry, 2012
Sequential cycloisomerizations of diynyl o-benzaldehyde substrates to access novel polycyclic cyclopropanes are reported. The reaction sequence involves initial Cu(I)-mediated cycloisomerization/nucleophilic addition to an isochromene followed by ...
Bo Leng, Stephanie Chichetti, Shun Su, Aaron B. Beeler, John A. Porco Jr.   +4 more
doaj   +1 more source

Enantioselective synthesis of non-proteinogenic 2-arylallyl-α-amino acids via Pd/In catalytic cascades [PDF]

, 2006
An efficient synthesis of both R- and S-enantiomers of 2-arylallyl-α-amino acids via a diastereoselective Pd/In mediated catalytic allylation of chiral N-sulfinyl-α-imino esters is described.
Anwar, Anwar, Cleghorn, Cleghorn, Colin Kilner, Colin W.G. Fishwick, Cooper, Cooper, Cooper, Davis, Ellman, Ellman, Evans, Grigg, Grigg, Hodgson, Hohsaka, John Blacker, Kevin Bailey, Najera, Ronald Grigg, Shaun McCaffrey, Stewart Korn, Visuvanathar Sridharan   +23 more
core   +1 more source

Recent developments in the asymmetric Reformatsky-type reaction

Beilstein Journal of Organic Chemistry, 2018
This review collects the most important developments in asymmetric Reformatsky-type reactions published since the beginning of 2013, including both diastereoselective methodologies based on the use of chiral substrates and enantioselective catalytic ...
Hélène Pellissier
doaj   +1 more source

Zn/ZnBr2 Catalysed Reaction of Aldehydes with Allylbromide: Synthesis of 2,6-Disubstituted 4-Bromotetrahydropyrans

SynOpen, 2022
An efficient approach for the one-pot synthesis of 4-bromotetrahydropyrans in a highly diastereoselective manner via the alkynylation followed by Prins cyclisation is described. The method employs aldehydes and allyl bromide as reactants, with a Zn/ZnBr2
D. O. Biradar, Y. D. Mane, Y. P. Sarnikar, S. G. Kulkarni, B. V. Subba Reddy, A. Venkat Narsaiah   +5 more
doaj   +1 more source