Results 71 to 80 of about 6,473 (220)
Chemistry – A European Journal, EarlyView.An Artificial metalloenzyme was designed by a Michael addition between a MnSalen complex and a cysteine residue within NikA crystals. The heterogeneous catalyst was found capable of an enantioselective and stereospecific epoxidation of cis‐β‐methylstyrene in cristallo.
Manel Boukhallat +8 more
wiley +1 more source
A concise enantioselective synthesis of the guaiane sesquiterpene (−)-oxyphyllol
Beilstein Journal of Organic Chemistry, 2013 (−)-Oxyphyllol was prepared in only 4 steps from an epoxy enone that already served as an intermediate for the total synthesis of the anticancer guaiane (−)-englerin A.
Martin Zahel, Peter Metz
doaj +1 more source
Titanium‐Catalyzed Diastereoselective Keto‐ and Iminonitrile Cyclizations
Chemistry – A European Journal, EarlyView.The titanium(III)‐catalyzed diastereoselective cyclization of readily‐available substituted ketonitriles gives cyclopentanones in good yield and stereoselectivity. Subsequent 1,2‐addition allows the preparation of cyclopentyls with three consecutive stereocenters.
Christoph Kern +4 more
wiley +1 more source
Diastereoselective Synthesis of β-Hydroxyketones
Natural Product Communications, 2008 The diastereoselective synthesis of 2,4-dibromo-3-hydroxy-1,3-diphenylbutan-1-one [ 4 ( a-a’ )]; 2,4-dibromo-3-hydroxy-1,3-di [( p -chloro)phenyl]butan-1-one [ 5 ( a-a’ )] and 2,4-dibromo-3-hydroxy-1,3-di[( p -phenyl)phenyl]butan-1-one [ 6(a-a’) ] using (
Teresa Mancilla Percino +2 more
doaj +1 more source
Molecules, 2017 A highly diastereoselective cyclopropanation of cyclic enones with sulfur ylides was developed under catalyst-free conditions, producing multifunctional spirocyclopropanes in generally excellent yields (up to 99% yield and >99:1 d.r.).
Yi Li +9 more
doaj +1 more source
FLP Mediated Conversion of Difluorobenzylalkynes to Fluoroallenyl Oniums via an SN1’ Pathway
Chemistry – A European Journal, EarlyView.Frustrated Lewis pair (FLP) selective C‒F activation of difluorobenzylalkynes allows the formation of fluoroallenic oniums via an SN1’ substitution pathway. The fluoroallenic onium salts are synthetic precursors that allow subsequent functionalization at allenic and onium positions.
Max Coles +6 more
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2016 A one-pot transformation, which involves the reaction of ketones with aldehydes in the presence of metal halides to furnish tetrahydro-2H-pyran-2,4-diols in a highly diastereoselective manner, is investigated thoroughly by experiments and computations ...
M. Emin Cinar +5 more
doaj +1 more source
Chemistry – A European Journal, EarlyView.Nitrooxylation—the installation of nitrate esters (–ONO2) has evolved from classical mixed‐acid protocols to catalytic and mechano‐, flow‐, photo‐, and electrochemical strategies. This review delineates ionic and radical manifolds for C–ONO2 bond formation, emphasizing mechanistic control, selected substrate scope, and selectivity.
Jayanta Dey, Dmitry Katayev
wiley +1 more source
Relay Approach: A Convergent Synthesis of Key Fragments en route to (+)‐Neosorangicin A
Chemistry – A European Journal, EarlyView.A selective synthesis of three key fragments of the antibiotically active (+)‐neosorangicin A is reported, providing a foundation for its convergent total synthesis and proof of strategy via a relay approach. ABSTRACT Herein, we report the synthesis of the three key fragments of the macrolide antibiotic (+)‐neosorangicin A, a compound exhibiting potent
Marvin Wenninger +6 more
wiley +1 more source
Stereochemical Control in the Matteson Reaction
Chemistry – A European Journal, EarlyView.The Matteson homologation is a highly versatile method for the stereoselective insertion of carbenoids into boronic esters. Through iterative application of the process, complex chiral molecules can be synthesized. The stereoselectivity of the reaction is determined by a chiral diol incorporated in the boronic ester.
Hae Mo Lee, Christoph Hirschhäuser
wiley +1 more source