Results 41 to 50 of about 186,279 (295)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Partial Information Differential Games for Mean-Field SDEs

, 2016
This paper is concerned with non-zero sum differential games of mean-field stochastic differential equations with partial information and convex control domain.
Xiao, Hua, Zhang, Shuaiqi
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Complementarity-based reformulation and numerical method for solving pursuit-evasion differential games

SICE Journal of Control, Measurement, and System Integration
Pursuit-evasion differential games are challenging to solve both analytically and numerically, particularly as the problem dimensionality increases. These games involve bounded control inputs for each player, reflecting the limitations commonly present ...
Feni Isdaryani, Kangyu Lin, Toshiyuki Ohtsuka   +2 more
doaj   +1 more source

Fast Reachable Set Approximations via State Decoupling Disturbances

, 2017
With the recent surge of interest in using robotics and automation for civil purposes, providing safety and performance guarantees has become extremely important.
Chen, Mo, Herbert, Sylvia, Tomlin, Claire J.   +2 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Distributed coordination of self-organizing mechanisms in communication networks [PDF]

, 2013
The fast development of the Self-Organizing Network (SON) technology in mobile networks renders the problem of coordinating SON functionalities operating simultaneously critical.
Altman, Eitan, Altman, Zwi, Combes, Richard, Tall, Abdoulaye   +3 more
core   +5 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Duality of the alternating integral for quasilinear differential games

Nonlinear Analysis, 2012
The concept of alternated integrals proved to be useful in differential games and in control theory under the conditions of uncertainty. In this article the connection between upper and lower alternating integrals for quasi-linear differential games is ...
Ikrom Iskanadjiev
doaj  

Robust control in two-player nonzero-sum LQ differential games with uncertainties: A spacecraft rendezvous case study

Franklin Open
This paper presents a novel framework for robust performance analysis in two-player nonzero-sum (NZS) linear-quadratic differential games under unknown uncertainties. Unlike existing methods that rely on specific or simplified uncertainty structures, our
Mohammad Bashiri, Tahereh Binazadeh, Meysam Azhdari   +2 more
doaj   +1 more source