Results 51 to 60 of about 18,357 (310)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

A Crash Course in Differential Games and Applications

Environmental and Resource Economics
The methodology of differential games is a combination of optimal control theory and game theory. It is the natural framework for economic analysis with strategic interaction and dynamical optimization. The theory gained traction by seminal papers in the
A. de Zeeuw
semanticscholar   +1 more source

A numerical method based on the complementarity and optimal control formulations for solving a family of zero-sum pursuit-evasion differential games

Journal of Computational and Applied Mathematics, 2020
This paper presents an efficient numerical method for a class of Zero-Sum Pursuit-Evasion Differential Games (ZSPEDGs). The aim of the presented method is to resolve the drawbacks of the indirect methods in solving ZSPEDGs.
Z. Yazdaniyan, M. Shamsi, Z. Foroozandeh, M. Pinho   +3 more
semanticscholar   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Executive Functioning in Alcoholics Following an mHealth Cognitive Stimulation Program: Randomized Controlled Trial

Journal of Medical Internet Research, 2014
BackgroundThe consequences of alcohol dependence are severe and may range from physical disease to neuropsychological deficits in several cognitive domains.
Gamito, Pedro, Oliveira, Jorge, Lopes, Paulo, Brito, Rodrigo, Morais, Diogo, Silva, Diana, Silva, Ana, Rebelo, Sara, Bastos, Marta, Deus, Alberto   +9 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Saddle-Point Equilibrium Strategy for Linear Quadratic Uncertain Stochastic Hybrid Differential Games Based on Subadditive Measures

Mathematics
This paper describes a kind of linear quadratic uncertain stochastic hybrid differential game system grounded in the framework of subadditive measures, in which the system dynamics are described by a hybrid differential equation with Wiener–Liu noise and
Zhifu Jia, Cunlin Li
doaj   +1 more source

Game-theoretic model of coordinations of interests at innovative development of corporations [PDF]

Компьютерные исследования и моделирование, 2016
Dynamic game theoretic models of the corporative innovative development are investigated. The proposed models are based on concordance of private and public interests of agents.
Gennady Anatolievich Ougolnitsky, Anatoly B. Usov   +1 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source