Results 261 to 270 of about 2,043,354 (309)

Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy

Advanced Science, EarlyView.
Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song, Can Zhao, Qiaoling Wang, Hongjiao Zhang, Xiao Liu, Linqi Wang, Michael Bromley, Wen‐Bing Yin   +7 more
wiley   +1 more source

The Mycorrhizal Fungal Species Funneliformis mosseae Reshapes Rhizosphere Microbial Metabolic Pathways of Soybeans Under Tetracycline Stress. [PDF]

Microbiologyopen
Yang C, Cai B, Chong HLH, Li J, Li L, Yong JWH, Chong KP.   +6 more
europepmc   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Multi-Omics Analysis Identifies Gut-Associated Metabolic Signatures Associated with Metformin-Mediated Protection Against LPS-Induced Lung Injury. [PDF]

Pharmaceuticals (Basel)
Cheng M, Zhang M, Wang W, Jia X, Cong B.
europepmc   +1 more source

The Effects of Different Storage Temperatures on Chemical Substance Changes in Saffron Stigmas Analyzed by LC-MS and GC-TOF-MS. [PDF]

Foods
Zhou L, Zhu J, Li X, Shao L, Xu Z, Xing L, Yang L, Zhang Y.   +7 more
europepmc   +1 more source

Comparative Analysis of Gut Metabolites in <i>Meles leucurus</i> Across Different Seasons. [PDF]

Animals (Basel)
Ma X, Zhang Y, Dong S, Sun M, Song Z, Wang X, Chen L.   +6 more
europepmc   +1 more source

Plasma metabolomic profiling identifies candidate biomarkers associated with sepsis diagnosis and mortality prediction. [PDF]

Front Immunol
Zhu Y, Wang H, Yi S, You F, Zhao P.
europepmc   +1 more source

An exploratory study of gut microbiota and serum metabolite profiles in type 2 diabetes patients with sleep disorders. [PDF]

Front Microbiol
Ma J, Zhang X, Pan Y, Bao X, Yi H, Hua J, Mu Q, Liu L, Hu C, Zhao D, Gao S.   +10 more
europepmc   +1 more source