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Exploiting key metabolic pathways of [PDF]

Biochemistry and Biophysics Reports
Mycobacterium tuberculosis ( Mtb ) caused disease Tuberculosis (TB) continues to be one of the leading causes of mortality although decades of medical research has progressed.
N. Thansila Parvin, Kaushik Chanda, M.M. Balamurali   +2 more
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Overexpression of enzymes in glycolysis and energy metabolic pathways to enhance coenzyme Q10 production in Rhodobacter sphaeroides VK-2-3

Frontiers in Microbiology, 2022
We subjected the components of the glycolysis and energy metabolism pathways of Rhodobacter sphaeroides (R. sphaeroides) to metabolic engineering to improve the titer and yield of coenzyme Q10 (CoQ10).
Long Zhang, Long Zhang, Long Zhang, Yong-li Li, Yong-li Li, Yong-li Li, Jian-hua Hu, Jian-hua Hu, Jian-hua Hu, Zhan-ying Liu, Zhan-ying Liu, Zhan-ying Liu   +11 more
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Pan-Cancer Identification of Prognostic-Associated Metabolic Pathways

Biology, 2023
Metabolic dysregulation has been reported involving in the clinical outcomes of multiple cancers. However, systematical identification of the impact of metabolic pathways on cancer prognosis is still lacking.
Wenbo Chen, Xin Chen, Zhenyu Zhao, Menglu Li, Shuang Dong, Sheng Hu, Xiaoyu Li, Mingqian Feng, Ke Chen, Shan Zhong, Chunjiang He   +10 more
doaj   +1 more source

The nuclear receptor CAR (NR1I3) regulates serum triglyceride levels under conditions of metabolic stress

Journal of Lipid Research, 2009
The nuclear receptor constitutive androstane receptor (CAR) (NR1I3) regulates hepatic genes involved in xenobiotic detoxification as well as genes involved in energy homeostasis.
Jodi M. Maglich, David C. Lobe, John T. Moore   +2 more
doaj   +1 more source

Characterization of microbial communities and predicted metabolic pathways in the uterus of healthy mares

Open Veterinary Journal, 2022
Background: Culture-independent techniques have made it possible to expand the knowledge about the composition of bacterial communities present in the healthy uterus and their role in health and disease, mainly in humans.
Pamela Thomson, Josefina Pareja, Andrea Nuñez, Rodrigo Santibañez, Rodrigo Castro   +4 more
doaj   +1 more source

Exploring glycosuria as a mechanism for weight and fat mass reduction. A pilot study with remogliflozin etabonate and sergliflozin etabonate in healthy obese subjects

Journal of Clinical & Translational Endocrinology, 2014
Inhibitors of sodium-dependent glucose co-transporter 2 (SGLT2) increase glucose excretion in the urine and improve blood glucose in Type 2 diabetes mellitus. Glycosuria provides an energy and osmotic drain that could alter body composition. We therefore
Antonella Napolitano, Sam Miller, Peter R. Murgatroyd, Elizabeth Hussey, Robert L. Dobbins, Edward T. Bullmore, Derek J.R. Nunez   +6 more
doaj   +1 more source

Activation of the Amino Acid Response Pathway Blunts the Effects of Cardiac Stress

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
Background The amino acid response (AAR) is an evolutionarily conserved protective mechanism activated by amino acid deficiency through a key kinase, general control nonderepressible 2.
Pu Qin, Pelin Arabacilar, Roberta E. Bernard, Weike Bao, Alan R. Olzinski, Yuanjun Guo, Hind Lal, Stephen H. Eisennagel, Michael C. Platchek, Wensheng Xie, Julius del Rosario, Mohamad Nayal, Quinn Lu, Theresa Roethke, Christine G. Schnackenberg, Fe Wright, Michael P. Quaile, Wendy S. Halsey, Ashley M. Hughes, Ganesh M. Sathe, George P. Livi, Robert B. Kirkpatrick, Xiaoyan A. Qu, Deepak K. Rajpal, Maria Faelth Savitski, Marcus Bantscheff, Gerard Joberty, Giovanna Bergamini, Thomas L. Force, Gregory J. Gatto, Erding Hu, Robert N. Willette   +31 more
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Correction to: HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction induced injury

Skeletal Muscle, 2018
Following publication of the original article [1], the authors flagged that there is a discrepancy with the Availability of data and materials statement on page 12 of the article.
Andrew N. Billin, Samuel E. Honeycutt, Alan V. McDougal, Jaclyn P. Kerr, Zhe Chen, Johannes M. Freudenberg, Deepak K. Rajpal, Guizhen Luo, Henning Fritz Kramer, Robert S. Geske, Frank Fang, Bert Yao, Richard V. Clark, John Lepore, Alex Cobitz, Ram Miller, Kazunori Nosaka, Aaron C. Hinken, Alan J. Russell   +18 more
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Stoichiometric synthesis of metabolic pathways [PDF]

Компьютерные исследования и моделирование, 2015
A vector-matrix approach to the theoretical design of metabolic pathways converting chemical compounds, viz., preset substrates, into desirable products is described.
Igor’ Georgievich Minkevich
doaj   +1 more source

Transcriptome analysis of human macrophages upon chikungunya virus (CHIKV) infection reveals regulation of distinct signaling and metabolic pathways during the early and late stages of infection

Heliyon, 2023
Macrophages are efficient reservoirs for viruses that enable the viruses to survive over a longer period of infection. Alphaviruses such as chikungunya virus (CHIKV) are known to persist in macrophages even after the acute febrile phase.
Priyanshu Srivastava, Sakshi Chaudhary, Surbhi Malhotra, Binuja Varma, Sujatha Sunil   +4 more
doaj   +1 more source