Results 21 to 30 of about 3,241,184 (308)

On functional module detection in metabolic networks [PDF]

open access: yes, 2013
Functional modules of metabolic networks are essential for understanding the metabolism of an organism as a whole. With the vast amount of experimental data and the construction of complex and large-scale, often genome-wide, models, the computer-aided ...
Koch, Ina   +3 more
core   +1 more source

Genome-Scale Investigation of the Metabolic Determinants Generating Bacterial Fastidious Growth

open access: yesmSystems, 2020
High proliferation rate and robustness are vital characteristics of bacterial pathogens that successfully colonize their hosts. The observation of drastically slow growth in some pathogens is thus paradoxical and remains unexplained.
Léo Gerlin   +6 more
doaj   +1 more source

Holistic evaluation of biodegradation pathway prediction: assessing multi-step reactions and intermediate products

open access: yesJournal of Cheminformatics, 2021
The prediction of metabolism and biotransformation pathways of xenobiotics is a highly desired tool in environmental sciences, drug discovery, and (eco)toxicology.
Jason Y. C. Tam   +3 more
doaj   +1 more source

TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei. [PDF]

open access: yes, 2014
The metabolic network of a cell represents the catabolic and anabolic reactions that interconvert small molecules (metabolites) through the activity of enzymes, transporters and non-catalyzed chemical reactions.
Opperdoes, F.R. (Fred)   +291 more
core   +2 more sources

Lipoprotein‐Associated Phospholipase A2 Activity Is a Marker of Risk But Not a Useful Target for Treatment in Patients With Stable Coronary Heart Disease

open access: yesJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundWe evaluated lipoprotein‐associated phospholipase A2 (Lp‐PLA2) activity in patients with stable coronary heart disease before and during treatment with darapladib, a selective Lp‐PLA2 inhibitor, in relation to outcomes and the effects of ...
Lars Wallentin   +60 more
doaj   +1 more source

Databases of metabolic pathways [PDF]

open access: yesBiochemistry and Molecular Biology Education, 2006
AbstractStudies of metabolism usually evoke memories of densely written wall charts of metabolic pathways of enormous complexity, such as the IUBMB‐Nicholson metabolic pathways map or the Roche metabolic pathways wall chart. Advances in bioinformatics in the past decade have brought about a revolution in the way the information in metabolic pathways is
openaire   +2 more sources

Assessment of Acute and Chronic Pharmacological Effects on Energy Expenditure and Macronutrient Oxidation in Humans: Responses to Ephedrine

open access: yesJournal of Obesity, 2011
Evidence of active brown adipose tissue in human adults suggests that this may become a pharmacological target to induce negative energy balance. We have explored whole-body indirect calorimetry to detect the metabolic effects of thermogenic drugs ...
Antonella Napolitano   +6 more
doaj   +1 more source

Metabolic responses of primary and transformed cells to intracellular Listeria monocytogenes. [PDF]

open access: yes, 2012
The metabolic response of host cells, in particular of primary mammalian cells, to bacterial infections is poorly understood. Here, we compare the carbon metabolism of primary mouse macrophages and of established J774A.1 cells upon Listeria monocytogenes
Wolfgang Eisenreich (108576)   +19 more
core   +1 more source

CORRELATION PROFILES OF THE ACCUMULATED METALS IN SEAWATER, SEDIMENT AND Pachygrapsus marmoratus (Fabricius) TISSUES IN BLACK SEA (ORDU, TURKEY)

open access: yesTrakya University Journal of Natural Sciences, 2018
This study was performed in order to investigate the interactions of accumulation patterns of some metals (Al, As, Cd, Cr, Cu, Fe, Mn, Ni, Pb and Zn) in exoskeleton, gill, hepatopancreas and muscle tissues of the marbled crab Pachygrapsus marmoratus ...
Şeyda Fikirdeşici Ergen   +4 more
doaj   +1 more source

Finding branched pathways in metabolic network via atom group tracking.

open access: yesPLoS Computational Biology, 2021
Finding non-standard or new metabolic pathways has important applications in metabolic engineering, synthetic biology and the analysis and reconstruction of metabolic networks.
Yiran Huang   +3 more
doaj   +1 more source

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