Results 281 to 290 of about 2,043,354 (309)

Differential Effects of Linoleic Acid Metabolites on Cardiac Sodium Current

The Journal of Pharmacology and Experimental Therapeutics, 2002
9,10-Epoxy-12-octadecenoic acid (EOA), a metabolite of linoleic acid, causes cardiac arrest in dogs. Other metabolites of linoleic acid also have toxic effects. This study investigates the mechanism of action of four of these compounds on cardiac Na(+) current (I(Na)).
Maddison D, Harrell, Joseph R, Stimers
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Phenolic metabolites of benzene inhibited the erythroid differentiation of K562 cells

Toxicology Letters, 2011
Benzene is a common occupational hazard and a ubiquitous environmental pollutant. Benzene exposure at the levels even below 1ppm still showed hematotoxicity. It is widely accepted that the metabolites of benzene play important roles in the benzene toxicity to the hematopoietic system, but little is known about the effects of benzene metabolites on ...
Xiao-Rong, Wu, Ming, Xue, Xiao-Fei, Li, Yan, Wang, Jie, Wang, Qing-Ling, Han, Zong-Chun, Yi   +6 more
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A study of urinary metabolites in patients with dicarboxylic aciduria for differential diagnosis

Pediatrics International, 1994
AbstractDicarboxylic aciduria (DCA‐uria) is a relatively common finding in the screening of organic acidemias by gas chromatography/mass spectrometry (GC/MS). A considerable number of patients with DCA‐uria are involved in disturbances of mitochondrial and peroxisomal fatty acid β‐oxidation. The differential diagnosis of DCA‐uria was investigated using
N, Shimizu, S, Yamaguchi, T, Orii
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Differential toxicities of cyclophosphamide and its glutathione metabolites to A549 cells

Toxicology in Vitro, 1995
Cyclophosphamide (CP), a widely used antineoplastic agent, is metabolized to species responsible for both the therapeutic and toxic effects of this drug. Acrolein is believed to be the primary toxic metabolite. This alpha,beta-unsaturated aldehyde reacts rapidly with glutathione (GSH) and can then be further metabolized to the mercapturic acid ...
C S, Perry, X, Liu, L G, Lund, C P, Whitman, J P, Kehrer   +4 more
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Role of Testosterone and its Metabolites in the Differentiation of the Mammary Gland in Rats

Endocrinology, 1976
The capacity of various androgens to virilize the differentiating mammary gland in the female rat fetus has been determined. Testosterone, 5alpha-androstane-3alpha, 17beta-diol (3alpha-diol), and dihydrotestosterone (DHT) virilize the anlagen of the mammary gland by suppressing nipple formation but 5alpha-androstane-3beta, 17beta-diol, androsterone ...
A S, Goldman, B, Shapiro, F, Neumann
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Osteoblast Differentiation and Control by Vitamin D and Vitamin D Metabolites

Current Pharmaceutical Design, 2004
Vitamin D plays a major role in the regulation of mineral homeostasis and affects bone metabolism. Most effects of vitamin D have been attributed to the 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) metabolite. 1,25-(OH)2D3 regulates its own metabolism by mediating the 24-hydroxylase activity, which leads to the degradation of the molecule but intermediate ...
Driel, Marjolein, Pols, Huib, van Leeuwen, Hans   +2 more
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Profiling of Biofluid Metabolites with a Kinetically Differentiated Binary Biosensing Platform

Analytical Chemistry
Biofluid metabolites have a crucial linkage with the health of the human body, and developing a universal method for metabolite monitoring is imperative for disease diagnosis and health management. Herein, we report a kinetically differentiated binary biosensing platform that is specifically responsive to NAD(P)H for profiling diverse biofluid ...
Bing Qi, Ziyun Miao, Jiahui Tan, Yingqian Wang, Jie Wang   +4 more
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Differential gut microbiota and microbial metabolites in adolescents with depression

Asian Journal of Psychiatry, 2023
Tian, Tian, Yinhua, Qin, Min, Wu, Wei, Wang, Tianyu, Song, Xingyi, Deng, Bing, Xu, Jing, Xie, Jian-Jun, Chen   +8 more
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Effects of whey on quality and differential metabolites of fermented camel jerky

Food Research International
To explore the effect of whey on the quality of camel meat products, this study developed a whey-fermented camel jerky and examined the impact of whey addition on the quality of fermented camel jerky. The effects of whey existence on the basic characteristics and differential metabolites of fermented camel meat jerky during storage were systematically ...
Jin, Li, Xige, He, Lu, Chen, Jin, Li, Xueting, Yu, Shaobo, Li, Gerelt, Borjigin, Tungalag, Dong, Xueyan, Yun   +8 more
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Cell Differentiation and Vitamin D (+ Metabolites)

1985
H. Reichel, H. P Koeffler, R. Barbers, R. Munker, A. W Norman, S. L. Teitelbaum, Z. Bar-Shavit, E H. Reitsma, H. G. Welgus, A. J. Kahn, U. Trechsel, V Evequoz, B. Hodler, H. Fleisch, T. Matsui, Y. Nakao, T. Nakagawa, T. Koizumi, Y Katakami, T. Sugiyama, T. Fujita, T. Suda, E. Abe, C. Miyaura, H. Tanaka, Y Shiina, T. Hayashi, H. Nagasawa, K. Chida, H. Hashiba, M. Fukushima, Y. Nishii, T. Kuroki, M. E. Harmand, L. Bordenave, R. Duphil, M. Thomasset, D. Ducassou, S. C. Manolagas, T. Yamamoto, T. Masuda, M. Matsuno, M. E Holick, B. D. Catherwood, J. E. Rubin, M. Kishihara, G. Mezzetti, B. Barbiroli, T. Oka, M. S. Cohen, R. L. Kaplan, C. N. D'Amico, R. C. Dodd, R. G. Snipes, D. E. Mesler, T. K. Gray, E Morel, D. Prowedini, D. Wegmann, J. Chiller, T. Shinki, C. E Daniel, A. Parreira, D. M. McCarth, H. S. Cross, R. A. Corradino, M. Peterlik, M. E. Markowitz, J. E Rosen, E. L. Smith, H. M. Holick, D. Millington, B. I. Weinberg, S. Ishizuka, M. T. Zarrabeitia, J. A. Riancho, M. C. Farinas, V Rodroguez-Valverde, J. Gonzalez-Macias   +78 more
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