Results 41 to 50 of about 2,043,354 (309)

Bile acid metabolites control TH17 and Treg cell differentiation [PDF]

Nature, 2018
Abstract Bile acids are abundantly present in the mammalian gut, where they undergo bacteria-mediated transformation, generating a large pool of bioactive molecules. While they have been shown to affect host metabolism, cancer progression and innate immunity, it is unknown whether bile acids affect the function of ...
Hang, S, Paik, D, Yao, L, Kim, E, Trinath, J, Lu, J, Ha, S, Nelson, BN, Kelly, SP, Wu, L, Zheng, Y, Longman, RS, Rastinejad, F, Devlin, AS, Krout, MR, Fischbach, MA, Littman, DR, Huh, JR   +17 more
openaire   +5 more sources

UPLC-QE-MS Analysis of the Differences in Milk Metabolites from Guanzhong Dairy Goats at the Peak and Late Lactation Stages [PDF]

Shipin Kexue
In order to explore the dynamic changes of metabolites in goat milk during different lactation periods, the differential metabolites in milk from Guanzhong dairy goats at the peak and late lactation stages were investigated by ultra-high performance ...
YU Mengqi, YUAN Yuxin, CHEN Lu, SHARI Akang, REN Xinyang, QU Yingxin, LI Guang
doaj   +1 more source

Metabolomics and Transcriptomics Analysis on Metabolic Characteristics of Oral Lichen Planus

Frontiers in Oncology, 2021
ObjectiveTo explore metabolic biomarkers related to erosive and reticulated oral lichen planus (OLP) by non-targeted metabolomics methods and correlate metabolites with gene expression, and to investigate the pathological network pathways of OLP from the
Ming-zhe Xin, Ming-zhe Xin, Ying-ying Shi, Ying-ying Shi, Chun-shen Li, Chun-shen Li, Li-hua Zuo, Li-hua Zuo, Na Li, Li-wei Liu, Li-wei Liu, He-xin Ma, He-xin Ma, Qiu-zheng Du, Qiu-zheng Du, Peng Xue, Zhi Sun, Zhi Sun, Hong-yu Zhao, Hong-yu Zhao   +19 more
doaj   +1 more source

Limited overlap of specific differential metabolites between strains.

, 2021
Yellow and red circles represent differential metabolites between strain Sylvio X10/4-infected and matched uninfected controls, and between strain CL-infected and matched uninfected controls, respectively.
James H. McKerrow (113918), Gautham Gautham (11520253), Danya A. Dean (11520250), Jair L. Siqueira-Neto (92312), Pieter C. Dorrestein (224907), Laura-Isobel McCall (222498)   +5 more
core   +1 more source

The characterization of metabolites alterations in white adipose tissue of diabetic GK Rats after ileal transposition surgery by an untargeted metabolomics approach

Adipocyte, 2021
Dysfunction of adipose tissue could lead to insulin resistance, obesity and type 2 diabetes. Thus, our present study aimed to investigate metabolites alterations in white adipose tissue (WAT) of diabetic GK rats after IT surgery.
Xiaorui Lyu, Kemin Yan, Weijie Chen, Yujie Wang, Huijuan Zhu, Hui Pan, Guole Lin, Linjie Wang, Hongbo Yang, Fengying Gong   +9 more
doaj   +1 more source

Analysis of brewing raw material components of sauce-flavor Baijiu based on non-targeted metabolomics [PDF]

Zhongguo niangzao
In order to analyze the composition of raw materials components for sauce-flavor (Jiangxiangxing) Baijiu brewing, physicochemical indexes of wheat and sorghum were detected, and the metabolites in two kinds of raw materials were analyzed by non-targeted ...
TANG Jiadai, WANG Yutong, HU Na, HE Junjun, GUO Min, MENG Zhuoni, LI Fangxiang
doaj   +1 more source

Metabolomics-based study of potential biomarkers of sepsis

Scientific Reports, 2023
The purpose of our study was to explore potential characteristic biomarkers in patients with sepsis. Peripheral blood specimens from sepsis patients and normal human volunteers were processed by liquid chromatography-mass spectrometry-based analysis ...
Yang Li, Chenglin Wang, Muhu Chen
doaj   +1 more source

Serum Metabolomic Profile in Hypoxia-Induced Pulmonary Hypertension Mice after C75 Treatment

Frontiers in Bioscience-Landmark, 2023
Background: Inhibition of fatty acid synthase (FAS) plays a crucial protective role in pulmonary hypertension (PH). Our aim was to identify novel metabolites in mice with hypoxia-induced PH after treatment with C75 (FAS inhibitor) and to confirm the ...
Shun Chen, Shujia Lin, Wei Liu, Qiuping Lin, Yi Yang, Qingzhu Qiu, Yanfang Zong, Tingting Xiao, Cuilan Hou, Lijian Xie   +9 more
doaj   +1 more source

Differential Retention of Gene Functions in a Secondary Metabolite Cluster

Molecular Biology and Evolution, 2017
In fungi, distribution of secondary metabolite (SM) gene clusters is often associated with host- or environment-specific benefits provided by SMs. In the plant pathogen Alternaria brassicicola (Dothideomycetes), the DEP cluster confers an ability to synthesize the SM depudecin, a histone deacetylase inhibitor that contributes weakly to virulence.
Hannah T, Reynolds, Jason C, Slot, Hege H, Divon, Erik, Lysøe, Robert H, Proctor, Daren W, Brown   +5 more
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Influence of nutrients and metabolites on the differentiation of plasma cells and implications for autoimmunity

Frontiers in Immunology, 2022
The modulation of inflammatory (auto)immune reactions by nutrients and gut bacterial metabolites is of great interest for potential preventive and therapeutic strategies. B cell-derived plasma cells are major players in inflammatory (auto)immune responses and can exhibit pro- or anti-inflammatory effects through (auto)antibody-dependent and ...
Bandik Föh, Bandik Föh, Jana Sophia Buhre, Christian Sina, Christian Sina, Marc Ehlers, Marc Ehlers   +6 more
openaire   +3 more sources