Results 61 to 70 of about 2,043,354 (309)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Metabolomic profiling of bovine leucocytes transformed by Theileria annulata under BW720c treatment
Parasites & Vectors, 2022 Background When Theileria annulata infects host cells, it undertakes unlimited proliferation as tumor cells. Although the transformed cells will recover their limited reproductive characteristics and enter the apoptosis process after treatment with ...
Hong-xi Zhao +4 more
doaj +1 more source
Identified differential metabolites in the HU+NAFLD serum.
, 2016 Identified differential metabolites in the HU+NAFLD serum.
Xiaojuan He (1930795) +13 more
core +1 more source
Acknowledgment to Reviewers of Metabolites in 2020
, 2021 Peer review is the driving force of journal development, and reviewers are gatekeepers who ensure that Metabolites maintains its standards for the high quality of its published papers [...
Metabolites Editorial Office Metabolites Editorial Office +2 more
core +1 more source
Experimental Biology and Medicine, 1953 SummarySeveral purine and pyrimidine derivatives reversed the growth inhibition of Aerobacter aerogenes caused by streptomycin under specified conditions. Inhibition by dihydrostreptomycin was not reversed under the same conditions. L-phenylalanine reversed the inhibition caused by dihydrostreptomycin and not that caused by streptomycin.
R F, PITTILO, J W, FOSTER
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Ten differential phytohormone metabolites of two chemotypes of P. cablin.
, 2023 Ten differential phytohormone metabolites of two chemotypes of P. cablin.
Mengling He (9472802) +6 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Progression indication ability of the identified differential metabolites.
, 2016 Progression indication ability of the identified differential metabolites.
Xiaojuan He (1930795) +13 more
core +1 more source