Liver organoids: modelling complexity in homeostasis and disease
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Screening results of differential metabolites between LPS group and NS group.
Screening results of differential metabolites between LPS group and NS group.
Na Pi (2946849) +7 more
core +1 more source
Metabolite composition of sinking particles reflects a changing microbial community and differential metabolite degradation [PDF]
Abstract Marine sinking particles transport carbon from the surface and bury it in deep sea sediments where it can be sequestered on geologic time scales. The combination of the surface ocean food web that produces these particles and the particle-associated microbial community that degrades these particles, creates a complex set of ...
Johnson, Winifred M. +7 more
openaire +1 more source
Impact of Benzene Metabolites on Differentiation of Bone Marrow Progenitor Cells [PDF]
Interleukin-3 (IL-3) and granulocyte/macrophage-colony-stimulating factor (GM-CSF) are responsible for maintaining survival and stimulating growth of early dormant hematopoietic progenitor cells (HPC). These cytokines exhibit extensive overlap, with GM-CSF supporting growth and differentiation of myeloid HPC.
R D, Irons, W S, Stillman
openaire +2 more sources
The microbiome in human skin aging
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
HPLC-based metabolomics of Dendrobium officinale revealing its antioxidant ability
Dendrobium officinale is an orchid with medicinal and nutritional properties that has received increasing attention because of its health benefits; however, there is limited information about the metabolic basis of these properties.
Zhengfei Luo +8 more
doaj +1 more source
KEGG pathway annotations for the differential metabolites in different growth periods.
KEGG pathway annotations for the differential metabolites in different growth periods.
Weiqiang Zhang (1333392) +8 more
core +1 more source
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Metabolomics and lipidomics of plasma biomarkers for tuberculosis diagnostics using UHPLC-HRMS
IntroductionDetermining metabolic profiles during host-pathogen interactions is crucial for developing novel diagnostic tests and exploring the mechanisms underlying infectious diseases.
Gaofeng Sun +7 more
doaj +1 more source
Identification results of differential metabolites in the roots of ZC_VS_CK castor plants.
Identification results of differential metabolites in the roots of ZC_VS_CK castor plants.
Wen Yanpeng (14709949) +10 more
core +1 more source

