Results 71 to 80 of about 4,395,934 (279)

DNA methylation profiling of the human major histocompatibility complex: A pilot study for the Human Epigenome Project [PDF]

, 2004
The Human Epigenome Project aims to identify, catalogue, and interpret genome-wide DNA methylation phenomena. Occurring naturally on cytosine bases at cytosine-guanine dinucleotides, DNA methylation is intimately involved in diverse biological processes ...
Gut, IG, Tost, J, Fischer, J, Hildmann, T, Lewin, J, Novik, KL, Beck, S, Cox, AV, Olek, A, Berlin, K, Otto, T, Howe, KL, Andrews, TD, Rakyan, VK   +13 more
core  

A meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex

Nature Communications, 2021
Although epigenome-wide association studies of Alzheimer’s disease have highlighted neuropathology-associated DNA methylation differences, previous studies have been limited in sample size and brain region used.
Rebecca G. Smith, Ehsan Pishva, Gemma Shireby, Adam R. Smith, Janou A. Y. Roubroeks, Eilis Hannon, Gregory Wheildon, Diego Mastroeni, Gilles Gasparoni, Matthias Riemenschneider, Armin Giese, Andrew J. Sharp, Leonard Schalkwyk, Vahram Haroutunian, Wolfgang Viechtbauer, Daniel L. A. van den Hove, Michael Weedon, Danielle Brokaw, Paul T. Francis, Alan J. Thomas, Seth Love, Kevin Morgan, Jörn Walter, Paul D. Coleman, David A. Bennett, Philip L. De Jager, Jonathan Mill, Katie Lunnon   +27 more
doaj   +1 more source

Paternal Sperm Gnas‐ICR Epigenetic Programming Contributes to PPP‐Like Phenotypes in Female Offspring

Advanced Science, EarlyView.
A paternal glucocorticoid–sperm Gnas‐ICR axis is linked to ovarian endocrine programming in female offspring. Paternal preconception caffeine exposure elevates corticosterone, promotes sperm Gnas‐ICR hypermethylation, and is associated with ovarian Gnas upregulation, cAMP/PKA/CREB–StAR activation, enhanced estradiol synthesis, and PPP‐like phenotypes ...
Jing Huang, Lu Chen, Tiancheng Wu, Yating Li, Hui Wang   +4 more
wiley   +1 more source

Genes with differentially methylated MAX binding sites at their promoters.

, 2023
(A) Shown is a Circos plot showing the location of genes with differentially methylated MAX binding sites. (B) Bar plot showing top gene ontology categories of differentially methylated MAX binding sites.
Tim Triche Jr (15368549), Mark S. Shiroishi (15368555), John D. Carpten (14895228), Ali Tafreshi (13546000), Gabriel Zada (275823), Alexander Micko (15368552), Douglass W. Tucker (14999925), Kyle T. Hurth (15368546), John D. Carmichael (5561180), Robin Du (15368540), Angad S. Gogia (15368543), Suhn K. Rhie (15169526), Dhiraj J. Pangal (15368537), Jacob Ruzevick (485552)   +13 more
core   +1 more source

Exploration of Biomarkers of Psoriasis through Combined Multiomics Analysis

Mediators of Inflammation, 2022
Background. Aberrant DNA methylation patterns are of increasing interest in the study of psoriasis mechanisms. This study aims to screen potential diagnostic indicators affected by DNA methylation for psoriasis based on bioinformatics using multiple ...
Lu Xing, Tao Wu, Li Yu, Nian Zhou, Zhao Zhang, Yunjing Pu, Jinnan Wu, Hong Shu   +7 more
doaj   +1 more source

Case report: Prenatal diagnosis of Kagami–Ogata syndrome in a Chinese family

Frontiers in Genetics, 2022
The aim of this work was to explore the genetic cause of the proband (Ⅲ2) presenting with polyhydramnios and gastroschisis. Copy number variation sequencing (CNV-seq), methylation-specific multiplex PCR (MS-PCR), and methylation-specific multiplex ...
Junjie Hu, Ying Zhang, Yanmei Yang, Liya Wang, Yixi Sun, Minyue Dong, Minyue Dong, Minyue Dong   +7 more
doaj   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

DNA methylation changes in CD4 T cells isolated from multiple sclerosis patients on dimethyl fumarate

Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2018
Background Dimethyl fumarate is an oral treatment for multiple sclerosis, whose mechanism of action is not fully understood. Objective To investigate the effects of dimethyl fumarate on DNA methylation in the CD4 + T cells of multiple sclerosis patients.
Vicki E Maltby, Rodney A Lea, Karen A Ribbons, Katherine A Sanders, Daniel Kennedy, Myintzu Min, Rodney J Scott, Jeannette Lechner-Scott   +7 more
doaj   +1 more source

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, EarlyView.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source

Characteristic DNA methylation profiles of chorionic villi in recurrent miscarriage

Scientific Reports, 2022
Dysregulation of transcriptional programs that are tightly regulated by DNA methylation during placental and fetal development at different gestational stages, may cause recurrent miscarriage.
Yosuke Matsumoto, Keiko Shinjo, Shoko Mase, Masaki Fukuyo, Kosuke Aoki, Fumiko Ozawa, Hiroyuki Yoshihara, Shinobu Goto, Tamao Kitaori, Yasuhiko Ozaki, Satoru Takahashi, Atsushi Kaneda, Mayumi Sugiura-Ogasawara, Yutaka Kondo   +13 more
doaj   +1 more source