Results 11 to 20 of about 2,784,026 (307)

Tracking autophagy during proliferation and differentiation of Trypanosoma brucei [PDF]

, 2014
Autophagy is a lysosome-dependent degradation mechanism that sequesters target cargo into autophagosomal vesicles. The Trypanosoma brucei genome contains apparent orthologues of several autophagy-related proteins including an ATG8 family. These ubiquitin-
Mottram, Jeremy, Jones, N.G., Coombs, Graham, Proto, William R   +3 more
core   +5 more sources

USP18 is an essential regulator of muscle cell differentiation and maturation [PDF]

, 2023
The ubiquitin proteasomal system is a critical regulator of muscle physiology, and impaired UPS is key in many muscle pathologies. Yet, little is known about the function of deubiquitinating enzymes (DUBs) in the muscle cell context.
den Hamer, Bianca, Hamer, B. den, Vendrell, Iolanda, Olie, C.S., Olie, Cyriel Sebastiaan, Kessler, B.M., Raz, V., Mei, Hailiang, de Greef, Jessica C, Pinto-Fernandez, A., Greef, J.C. de, Vendrell, I., Pinto-Fernández, Adán, Damianou, A., van der Wal, Erik, Kessler, Benedikt M, Wal, E. van der, Mei, H.L., Damianou, Andreas, Raz, Vered   +19 more
core   +1 more source

Rapid generation of secondary fibroblasts through teratoma formation

BioTechniques, 2015
The use of secondary or reprogrammable cells in the production of induced pluripotent stem cells (iPSCs) circumvents random infection by various viral particles and random, uncontrollable integrations of the viral genomes into different genomic loci.
Sang Mi Cho, Jung Sun Park, Byungkuk Min, Sujin Kwon, Yong-Kook Kang   +4 more
doaj   +1 more source

Palmitate differentially regulates the polarization of differentiating and differentiated macrophages [PDF]

Immunology, 2015
SummaryThe tissue accumulation of M1 macrophages in patients with metabolic diseases such as obesity and type 2 diabetes mellitus has been well‐documented. Interestingly, it is an accumulation of M2 macrophages that is observed in the adipose, liver and lung tissues, as well as in the circulation, of patients who have had major traumas such as a burn ...
Fangming, Xiu, Li, Diao, Peter, Qi, Michael, Catapano, Marc G, Jeschke   +4 more
openaire   +2 more sources

Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells [PDF]

, 2015
© 2015 Macmillan Publishers Limited. All rights reserved. microRNA-34a (miR-34a) and sirtuin 1 (SirT1) have been extensively studied in tumour biology and longevityaging, but little is known about their functional roles in smooth muscle cell (SMC ...
L A Luong, Wen, G., Q Chen, Luong, LA, Q Xiao, Zhu, J, Zhu, J., Chen, Q, Y Huang, Luong, L. A., Zhang, L., Ye, S., H Zhao, G Wen, Wang, W, L Zhang, Xu, Q., Yu, X., Wen, G, Xiao, Q, Ye, S, Huang, Y, Q Xu, Zhao, H, X Yu, Huang, Y., Xu, Q, W Wang, Chen, Q., J Zhu, Yu, X, Zhang, L, Wang, W., Xiao, Q., Zhao, H., S Ye   +35 more
core   +1 more source

Differentiation of differentiation

SSRN Electronic Journal, 2012
Increased global competitiveness, reduced product life cycles, rapid technological advancements, and dynamic customer requirements have drastically altered the nature of competition. Henderson (1989) argues that two firms cannot coexist if they make their livings in identical ways and that’s the reason why firm distinguish from its rivals.
Ivančić, Valentina, Jelenc, Lara
openaire   +3 more sources

Combination of metformin/efavirenz/fluoxetine exhibits profound anticancer activity via a cancer cell-specific ROS amplification

Cancer Biology & Therapy, 2023
The possible anticancer activity of combination (M + E + F) of metformin (M), efavirenz (E), and fluoxetine (F) was investigated in normal HDF cells and HCT116 human colon cancer cells.
Beom-Goo Kang, Madhuri Shende, Gozde Inci, Soo-Hyun Park, Jun-Sub Jung, Set Byeol Kim, Jeong Hoon Kim, Young Won Mo, Ji-Hyeon Seo, Jing-Hui Feng, Sung-Chan Kim, Soon Sung Lim, Hong-Won Suh, Jae-Yong Lee   +13 more
doaj   +1 more source

Efficient definitive endoderm induction from mouse embryonic stem cell adherent cultures: A rapid screening model for differentiation studies

Stem Cell Research, 2014
Definitive endoderm (DE) differentiation from mouse embryonic stem cell (mESC) monolayer cultures has been limited by poor cell survival or low efficiency.
Josué Kunjom Mfopou, Marloes Geeraerts, Roba Dejene, Stijn Van Langenhoven, Asma Aberkane, Leo A. Van Grunsven, Luc Bouwens   +6 more
doaj   +1 more source

DIFFERENTIAL GEOMETRY FROM DIFFERENTIAL EQUATIONS [PDF]

The Ninth Marcel Grossmann Meeting, 2001
37 pages, revised version with ...
Frittelli, Simonetta, Kozameh, Carlos, Newman, Ezra T.   +2 more
openaire   +2 more sources

Mesenchymal stromal cells derived from cervical cancer produce high amounts of adenosine to suppress cytotoxic T lymphocyte functions

Journal of Translational Medicine, 2016
Background In recent years, immunomodulatory mechanisms of mesenchymal stem/stromal cells (MSCs) from bone marrow and other “classic” sources have been described. However, the phenotypic and functional properties of tumor MSCs are poorly understood.
María de Lourdes Mora-García, Rosario García-Rocha, Omar Morales-Ramírez, Juan José Montesinos, Benny Weiss-Steider, Jorge Hernández-Montes, Luis Roberto Ávila-Ibarra, Christian Azucena Don-López, Marco Antonio Velasco-Velázquez, Vianey Gutiérrez-Serrano, Alberto Monroy-García   +10 more
doaj   +1 more source