Results 11 to 20 of about 4,094,095 (307)

Machine learning identifies phenotypic profile alterations of human dopaminergic neurons exposed to bisphenols and perfluoroalkyls

open access: yesScientific Reports, 2023
Parkinson’s disease (PD) is the second most common neurodegenerative disease and is characterized by the loss of midbrain dopaminergic neurons. Endocrine disrupting chemicals (EDCs) are active substances that interfere with hormonal signaling. Among EDCs,
Andrea Di Credico   +6 more
doaj   +1 more source

N-Acetylcysteine Reduces the Pro-Oxidant and Inflammatory Responses during Pancreatitis and Pancreas Tumorigenesis

open access: yesAntioxidants, 2021
Pancreatitis, an inflammation of the pancreas, appears to be a main driver of pancreatic cancer when combined with Kras mutations. In this context, the exact redox mechanisms are not clearly elucidated.
Marie-Albane Minati   +4 more
doaj   +1 more source

Rapid generation of secondary fibroblasts through teratoma formation

open access: yesBioTechniques, 2015
The use of secondary or reprogrammable cells in the production of induced pluripotent stem cells (iPSCs) circumvents random infection by various viral particles and random, uncontrollable integrations of the viral genomes into different genomic loci.
Sang Mi Cho   +4 more
doaj   +1 more source

Palmitate differentially regulates the polarization of differentiating and differentiated macrophages [PDF]

open access: yesImmunology, 2015
SummaryThe tissue accumulation of M1 macrophages in patients with metabolic diseases such as obesity and type 2 diabetes mellitus has been well‐documented. Interestingly, it is an accumulation of M2 macrophages that is observed in the adipose, liver and lung tissues, as well as in the circulation, of patients who have had major traumas such as a burn ...
Fangming, Xiu   +4 more
openaire   +2 more sources

CD8+ T cell differentiation and dysfunction in cancer

open access: yesNature reviews. Immunology, 2021
CD8+ T cells specific for cancer cells are detected within tumours. However, despite their presence, tumours progress. The clinical success of immune checkpoint blockade and adoptive T cell therapy demonstrates the potential of CD8+ T cells to mediate ...
M. Philip, A. Schietinger
semanticscholar   +1 more source

Combination of metformin/efavirenz/fluoxetine exhibits profound anticancer activity via a cancer cell-specific ROS amplification

open access: yesCancer Biology & Therapy, 2023
The possible anticancer activity of combination (M + E + F) of metformin (M), efavirenz (E), and fluoxetine (F) was investigated in normal HDF cells and HCT116 human colon cancer cells.
Beom-Goo Kang   +13 more
doaj   +1 more source

DIFFERENTIAL GEOMETRY FROM DIFFERENTIAL EQUATIONS [PDF]

open access: yesThe Ninth Marcel Grossmann Meeting, 2001
37 pages, revised version with ...
Frittelli, Simonetta   +2 more
openaire   +2 more sources

Efficient definitive endoderm induction from mouse embryonic stem cell adherent cultures: A rapid screening model for differentiation studies

open access: yesStem Cell Research, 2014
Definitive endoderm (DE) differentiation from mouse embryonic stem cell (mESC) monolayer cultures has been limited by poor cell survival or low efficiency.
Josué Kunjom Mfopou   +6 more
doaj   +1 more source

Mesenchymal stromal cells derived from cervical cancer produce high amounts of adenosine to suppress cytotoxic T lymphocyte functions

open access: yesJournal of Translational Medicine, 2016
Background In recent years, immunomodulatory mechanisms of mesenchymal stem/stromal cells (MSCs) from bone marrow and other “classic” sources have been described. However, the phenotypic and functional properties of tumor MSCs are poorly understood.
María de Lourdes Mora-García   +10 more
doaj   +1 more source

Differentiation of Effector CD4 T Cell Populations

open access: yesAnnual Review of Immunology, 2010
CD4 T cells play critical roles in mediating adaptive immunity to a variety of pathogens. They are also involved in autoimmunity, asthma, and allergic responses as well as in tumor immunity.
Jinfang Zhu, H. Yamane, W. Paul
semanticscholar   +1 more source

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