Results 181 to 190 of about 3,859 (214)

Phase I evaluation of intravenous difluoromethylornithine — a polyamine inhibitor

Investigational New Drugs, 1985
Difluoromethylornithine (DFMO), a non-competitive inhibitor of ornithine decarboxylase (ODC), the rate limiting enzyme of the polyamine synthetic pathway was evaluated in a Phase I trial. Intravenous DFMO was given to twenty patients with refractory leukemia by continuous infusion in doses from 5.5 to 64 g/m2.
A M, Maddox, M J, Keating, K E, McCredie, E, Estey, E J, Freireich   +4 more
openaire   +2 more sources

Inhibition of Leishmania Species by α-Difluoromethylornithine

1989
DL- α-difluoromethylornithine (DFMO) is a specific, irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in trypanosome polyamine biosynthesis (reviewed in 1). DFMO cures experimental infections of African trypanosomiasis, and is in phase 1 clinical trials2. Although the mechanism of selective toxicity is incompletely known,
Jan S. Keithly, Alan H. Fairlamb
openaire   +1 more source

Evaluation of Difluoromethylornithine for the Chemoprevention of Barrett's Esophagus and Mucosal Dysplasia

Cancer Prevention Research, 2011
Abstract Patients with Barrett's esophagus (BE) and dysplasia are candidates for chemopreventive strategies to reduce cancer risk. We determined the effects of difluoromethylornithine (DMFO) on mucosal polyamines, gene expression, and histopathology in BE. Ten patients with BE and low-grade dysplasia participated in a single-arm study of
Frank A, Sinicrope, Russell, Broaddus, Nina, Joshi, Eugene, Gerner, Elizabeth, Half, Ilan, Kirsch, Jan, Lewin, Bruce, Morlan, Waun Ki, Hong   +8 more
openaire   +2 more sources

Importance of the duration of inhibition on intestinal carcinogenesis by difluoromethylornithine in rats

Cancer Letters, 1987
The effect of the duration and sequence of inhibition of intestinal tumor formation in rats was studied to determine whether part time inhibition has any value. Four groups of male Sprague-Dawley rats were given 8 weekly s.c. injections of azoxymethane (AOM) 8 mg/rat. Three groups were given the inhibitor, difluoromethylornithine (DFMO) in the drinking
N D, Nigro, A W, Bull, M E, Boyd
openaire   +2 more sources

Prevention of metastasis of intraocular melanoma in mice treated with difluoromethylornithine

Graefe's Archive for Clinical and Experimental Ophthalmology, 1992
The antimetastatic potential of a novel chemotherapeutic agent, alpha-difluoromethylornithine (DFMO), was evaluated in a murine model of intraocular melanoma. In vivo studies demonstrated that DFMO retarded the growth and spontaneous metastasis of murine intraocular melanomas.
G, Sanborn, J, Niederkorn, J, Kan-Mitchell, D, Albert   +3 more
openaire   +2 more sources

Growth inhibition of a prostate tumor by α-difluoromethylornithine and by cyclophosphamide

Cancer Letters, 1982
The effects of the ornithine decarboxylase suicide substrate, difluoromethylornithine (DFMO), and of cyclophosphamide, individually and in combination, on the growth of the R3327MAT-Lu prostate derived tumor were determined. DFMO decreased the growth rate and resulted in a 75% reduction in DNA content compared to the control group.
W D, Heston, D, Kadmon, W R, Fair
openaire   +2 more sources

Effect of difluoromethylornithine on atrial natriuretic peptide in rat atria

Regulatory Peptides, 1993
Polyamines are aliphatic cations known to have a role in cellular growth and differentiation. In this study, difluoromethylornithine (DFMO), an inhibitor of polyamine synthesis, was used to investigate its effect on atrial natriuretic peptide (ANP) in atria of rat.
U R, Tipnis, J B, Gentry, J, Gutkowska
openaire   +2 more sources

Further studies on difluoromethylornithine in African trypanosomes.

Medical biology, 1982
DL-alpha-Difluoromethylornithine (DFMO), a specific enzyme-activated irreversible inhibitor of ornithine decarboxylase (ODC) was previously shown to cure mice infected with Trypanosoma brucei brucei, a parasite of game and cattle in Africa and Trypanosoma brucei rhodesiense, a human African Sleeping Sickness pathogen. Our studies now indicate that DFMO
P P, McCann, C J, Bacchi, A B, Clarkson, J R, Seed, H C, Nathan, B O, Amole, S H, Hutner, A, Sjoerdsma   +7 more
openaire   +1 more source

Difluoromethylornithine and Formycin B in Toxoplasmosis

Journal of Infectious Diseases, 1985
J M, Hofflin, D R, Guptill, F G, Araujo, J S, Remington   +3 more
openaire   +2 more sources

Uptake of α-difluoromethylornithine by mouse fibroblasts

Biochemical Pharmacology, 1982
B G, Erwin, A E, Pegg
openaire   +2 more sources