Results 71 to 80 of about 40,361 (295)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Determination of true digestible amino acids of feedstuffs utilizing cecectomized roosters

Revista Brasileira de Zootecnia, 2012
The objective of this study was to estimate the true digestibility coefficients of amino acids and digestible amino acid values of some poultry feedstuffs.
Eliane Aparecida da Silva, Luiz Fernando Teixeira Albino, Horacio Santiago Rostagno, Rodolfo Alves Vieira, Valdir Ribeiro Junior, Anastácia Maria de Araújo Campos, João Paulo Leles Pereira   +6 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Digestible lysine levels in diets supplemented with ractopamine

Revista Brasileira de Zootecnia, 2011
In order evaluate digestible lysine levels in diets supplemented with 20 ppm of ractopamine on the performance and carcass traits, 64 barrows with high genetic potential at finishing phase were allotted in a completely randomized block design with four ...
Evelar de Oliveira Souza, Douglas Haese, João Luís Kill, Ismail Ramalho Haddade, Elcio das Graça Lacerda, Alysson Saraiva, Francisco Carlos de Oliveira Silva, Rodrigo Pereira Sobreiro   +7 more
doaj   +1 more source

UTILISING Zn AND Cu PRODU T IN THE CORN MEAL SUBSTRATE AT Saccharomyces cerev s ae BIOPRO ESS AND ITS IMPLEMENTATION ON INTERNAL QUALITY OF BROILER [PDF]

, 2009
This research was conducte to find out the effect and optimal percentage of adding Zn and Cu proteinat supplement product of fermentation by Saccharomyces cerev s ae in the ration on internal quality of the broiler.The experiment use 125 broiler day ol
Abun, Abun, Darana, S, Destian, A, Widjastuti, T   +3 more
core  

Influence of ruminal degradable intake protein restriction on characteristics of digestion and growth performance of feedlot cattle during the late finishing phase. [PDF]

, 2014
Two trials were conducted to evaluate the influence of supplemental urea withdrawal on characteristics of digestion (Trial 1) and growth performance (Trial 2) of feedlot cattle during the last 40 days on feed.
Calderon, Jose F, Gonzalez, Victor M, May, Dixie, Montano, Martin, Plascencia, Alejandro, Salinas-Chavira, Jaime, Torrentera, Noemi, Zinn, Richard A   +7 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Sunflower meal for broilers of 22 to 42 days of age

Revista Brasileira de Zootecnia, 2011
The objective of the present experiment was to evaluate the inclusion of sunflower meal in diets formulated on total or digestible amino acid basis fed to broilers of 22 to 42 days of age.
Lúcio Francelino Araújo, Cristiane Soares da Silva Araújo, Natália Barros Petroli, Antonio Carlos de Laurentiz, Ricardo de Albuquerque, Messias Alves de Trindade Neto   +5 more
doaj   +1 more source

Standardized Ileal Amino Acid Digestibility of Commonly Used Feed Ingredients in Growing Broilers [PDF]

Asian-Australasian Journal of Animal Sciences, 2016
This experiment was conducted to determine standardized ileal amino acid digestibility (SIAAD) of commonly used feed ingredients in poultry diets in Pakistan.
Zafar Ullah, Gulraiz Ahmed, Mehr un Nisa, Muhammad Sarwar   +3 more
doaj   +1 more source

Nitrogen and energy partitioning in two genetic groups of pigs fed low-protein diets at 130 kg body weight [PDF]

, 2015
The aim was to evaluate the effect of low-protein (LP) or low-amino acid diets on digestibility, energy and nitrogen (N) utilisation in 2 genetic groups (GG) of pigs (129±11 kg BW). Duroc×Large White (A) pigs were chosen to represent a traditional GG for
Colombini, Stefania, Crovetto, Gianni M., Galassi, Gianluca, Gallo, Luigi, Malagutti, Luca, Rapetti, Luca, Schiavon, Stefano, Tagliapietra, Franco   +7 more
core   +3 more sources