Results 71 to 80 of about 1,286,089 (305)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Effect of Digestible Protein and Sulfur Amino Acids in Starter Diet on Performance and Small Intestinal (Jejunum) Morphology of Broilers

پژوهشهای علوم دامی ایران, 2016
Introduction Protein is an essential constituent of all tissues of animal body and has major effect on growth performance of the bird. A better understanding of the nutritional requirements of amino acids allows a more precise nutrition, offering the ...
Avisa Akhavan khaleghi, Abolghasem Golian, Ahmad Hasan Abadi, Ahmad Reza Raaji   +3 more
doaj  

Structural analyses combined with small-angle X-ray scattering reveals that the retention of heme is critical for maintaining the structure of horseradish peroxidase under denaturing conditions.

, 2018
We analyzed the structure of horseradish peroxidase (HRP) under denaturing conditions of 9 M urea or 6 M guanidine hydrochloride (GdnHCl). Far-UV circular dichroism (CD) spectra indicated the existence of native-like secondary structure of holo-HRP in 9 ...
Jang, D.S, Choi, K.Y., Jin, K.S, Cha, H.J   +3 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Ionization characteristics of amino acids in direct analysis in real time mass spectrometry. [PDF]

, 2014
The positive and negative ionization characteristics of 20 different α-amino acids were investigated using Direct Analysis in Real Time (DART) mass spectrometry. Almost all of the amino acids M were ionized to generate the (de)protonated analytes [M ± H](
Sekimoto, Kanako, Hike, Hiroshi, Takayama, Mitsuo, Shiota, Teruhisa, セキモト, カナコ, Kawamukai, Takatomo, 関本, 奏子, Sakakura, Motoshi, Usui, Fumihiko, Bando, Yasuhiko   +9 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

True ileal amino acid digestibility and digestible indispensable amino acid scores (DIAASs) of cooked tropical peas

Food Research International
Tropical peas can be used as both animal feed and human food but the nutritional quality of their proteins for humans is currently poorly documented. Here, 3 varieties of tropical peas were studied at two stages of seed maturity (green or dry): Cajanus Cajan (CC), Vigna Unguiculata (VU) and Lablab Purpureus (LP).
David, Jérémie, Buffière, Caroline, Hafnaoui, Noureddine, Migné, Carole, Bambou, Jean-Christophe, Archimède, Harry, Rémond, Didier   +6 more
openaire   +3 more sources

Utilization of ileal digestible amino acids by growing pigs: threonine [PDF]

British Journal of Nutrition, 1991
An experiment was conducted to determine the utilization of ileal digestible threonine by growing pigs. Three threonine-deficient diets (0.22 g ileal digestible threonine/MJ digestible energy (DE)) were formulated using cottonseed meal, meat-and-bone meal and soya-bean meal respectively, as the only source of threonine in the diet.
S A, Beech, E S, Batterham, R, Elliott
openaire   +4 more sources

Effect of variety, growing region and growing season on digestible energy content of wheats grown in Western Australia for weaner pigs [PDF]

, 2004
An experiment was conducted to examine the digestible energy (DE) content for weanling pigs in a cohort of wheats grown in Western Australia, and to establish relationships between DE content and their chemical composition.
Pluske, J.R., Mullan, B.P., Simmins, P.H., Kim, J.C.   +3 more
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source