Results 221 to 230 of about 118,223,277 (257)

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source

Nutrient Digestibility, Chitin Recovery and Antioxidant Capacity of <i>Tenebrio molitor</i> Larvae Meal in Canine- and Feline-Adapted In Vitro Digestion Using a Conventional Fish Meal as References. [PDF]

Animals (Basel)
Dametti MR, Frazzini S, Ferri I, Dell'Anno M, Spedale C, Ruffo G, Rossi L.   +6 more
europepmc   +1 more source

Lactate‐Induced K370 Lactylation of STING Inhibits STING‐TBK1 Signaling and Dampens Anti‐Tumor Immunity

Advanced Science, EarlyView.
Lactate accumulation in glioblastoma drives lactylation of STING at lysine 370, a primate‐conserved residue. K370 lactylation weakens STING‐TBK1 binding, destabilizes STING, and disrupts ER‐to‐Golgi trafficking, blunting type I interferon signaling. LDHA inhibition reverses K370 lactylation and improves the antitumor efficacy of STING agonism combined ...
Yueyao Wu, Jingzhe Wang, Xu Chen, Yuntong Yang, Ping Wei, Han Xie, Honghao Wang, Chunyu Zhang, Siyi Xu, Qi Wang, Chunlong Zhong, Jing Zhang   +11 more
wiley   +1 more source

Enzyme-Assisted Extraction and Hydrolysis of Dulse (<i>Palmaria palmata</i>) Proteins: Characterisation, Antioxidant Activity and Glucose-Management Potential. [PDF]

Foods
Amigo-Benavent M, Chen Y, Idowu AT, FitzGerald RJ.   +3 more
europepmc   +1 more source

Klotho‐Derived Peptide 1 Protects against Acute Kidney Injury by Directly Targeting Mitochondrial ATAD3A

Advanced Science, EarlyView.
This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang, Shihui Lin, Tianyu Wu, Zhixin Zhang, Hong Zhou, Xue Hong, Youhua Liu   +6 more
wiley   +1 more source

Polysaccharides from Er Chen Decoction: gastrointestinal fate, gut microbiota modulation and metabolomics. [PDF]

Front Microbiol
Liu YJ, Wang ZK, Yue LT, Qiao D, Deng QL, Chang XY, Liu T, Hu MB.   +7 more
europepmc   +1 more source

ROS‐Responsive Eye Drop for Controlled Release of 20‐Deoxyingenol Improves Diabetic Corneal Healing by Activating Macrophage Autophagy and Metabolic Reprogramming

Advanced Science, EarlyView.
Schematic illustration of ROS‐responsive TSPBA‐PVA microspheres loaded with 20‐deoxyingenol (TP/20‐DOI) for diabetic corneal wound healing: (a) fabrication and ROS‐triggered release; (b) autophagy activation and metabolic reprogramming in macrophages; (c) suppression of macrophage‐derived CXCL3/CXCL5, attenuation of neutrophil infiltration, and ...
Jiaxin Wu, Wanying Chen, Haijiang Qiu, Weihan Zheng, Ying Jiao, Jingheng Du, Zhudan Zhuang, Xing Hua, Jingyi Gu, Yuheng Liu, Zhaojin Li, Jingbin Xie, Hanxiao Sun, Huifei Lan, Xin Sun, Yunxia Xue, Ting Fu, Zhijie Li, Guobing Chen, Shiyu Li, Jun Liu   +20 more
wiley   +1 more source

Clogmia albipunctata fails to induce true intestinal myiasis: Evidence from in vitro and in vivo digestive models. [PDF]

PLoS One
Zhan H, Zhang L, Ge L, Chen Y, Zhang P, Jiao Y, Luo X, Xia H, Fang Q, Tao Z.   +9 more
europepmc   +1 more source

Multielement Composition and in Vitro Bioaccessibility in Brazilian Edible Floral Supplement Capsules Containing Dandelion and Hibiscus. [PDF]

Biol Trace Elem Res
Fiais TLS, Freitas Junior JM, Brito YFG, da Silva ES, de Jesus Benevides CM, de Souza TL, Santana JS, de Freitas Santos Júnior A.   +7 more
europepmc   +1 more source