Results 91 to 100 of about 10,900 (273)

Digitoxin analogues with improved anticytomegalovirus activity.

open access: yesACS Medicinal Chemistry Letters, 2014
Cardiac glycosides are potent inhibitors of cancer cell growth and possess antiviral activities at nanomolar concentrations. In this study we evaluated the anticytomegalovirus (CMV) activity of digitoxin and several of its analogues.
Hongyi Cai   +8 more
semanticscholar   +1 more source

GC–MS and FTIR Characterization of Bioactive Compounds in Aqueous Extracts of Terminalia laxiflora Root and Mitragyna inermis Stem Bark

open access: yesJournal of Chemistry, Volume 2025, Issue 1, 2025.
The contribution of medicinal plants in healthcare delivery has been acknowledged due to the numerous plant chemicals with health‐promoting properties. In Northern Ghana, where health resources are scarce coupled with endemic poverty, most traditional folks rely heavily on plants as a source of treatment.
Sylvenus Aguree   +3 more
wiley   +1 more source

Tools for clinical pharmacists to identify medications that can cause drug‐induced cognitive impairment: A systematic review

open access: yesJACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, Volume 7, Issue 12, Page 1207-1227, December 2024.
Abstract Cognitive impairment affects around 19% of community‐dwelling older adults in the United States. Pharmacists can play a significant role in identifying and deprescribing cognitive‐impairing medications through cognitive‐focused medication reviews or as part of comprehensive medication management.
Jacob Stanton   +4 more
wiley   +1 more source

CLINICAL NOTES ON DIGITOXIN. [PDF]

open access: yesJAMA: The Journal of the American Medical Association, 1899
Among the few really indispensable drugs which we have, digitalis would be placed in the very front rank by most medical men, and this is true in spite of the fact that its use is attended by certain disadvantages, and that these disadvantages are not regularly to be estimated, owing to the complex nature of the constituents of the drug, and the ...
openaire   +3 more sources

Absorption and Transport of Digitoxin in the Dog [PDF]

open access: yesCirculation Research, 1971
Absorption of digitoxin as its studied in 14 fasted anesthetized dogs after administration of 50 µc of 3 H-digitoxin mixed with 1 mg of unlabeled digitoxin into either the duodenum or stomach. Radioactivity was measured in portal, hepatic, and central venous plasma, thoracic duct lymph, common duct bile and urine ...
Marlys H. Witte   +3 more
openaire   +3 more sources

Efficacy and safety of low‐dose digoxin in patients with heart failure. Rationale and design of the DECISION trial

open access: yesEuropean Journal of Heart Failure, Volume 26, Issue 10, Page 2223-2230, October 2024.
Rationale and design of the DECISION trial. ECG, electrocardiogram; HF, heart failure; LVEF, left ventricular ejection fraction; NT‐proBNP, N‐terminal pro‐B‐type natriuretic peptide; NYHA, New York Heart Association. Abstract Aims Digoxin is the oldest drug in cardiovascular (CV) medicine, and one trial conducted >25 years ago showed a reduction in ...
Dirk J. van Veldhuisen   +36 more
wiley   +1 more source

Multipoint Costriking Nanodevice Eliminates Primary Tumor Cells and Associated‐Circulating Tumor Cells for Enhancing Metastasis Inhibition and Therapeutic Effect on HCC

open access: yesAdvanced Science, 2022
Eliminating primary tumor (“roots”) and inhibiting associated‐circulating tumor cells (associated‐CTCs, “seeds”) are vital issues that need to be urgently addressed in cancer therapy.
Weiwei Mu   +10 more
doaj   +1 more source

Functional modulation of the transient outward current Ito by KCNE beta-subunits and regional distribution in human non-failing and failing hearts [PDF]

open access: yes, 2006
Objectives: The function of Kv4.3 (KCND3) channels, which underlie the transient outward current I,, in human heart, can be modulated by several accessory subunits such as KChIP2 and KCNE1-KCNE5.
Banse, U.   +8 more
core   +1 more source

The phytochemical composition of Melia volkensii and its potential for insect pest management [PDF]

open access: yes, 2020
Due to potential health and environmental risks of synthetic pesticides, coupled with their non-selectivity and pest resistance, there has been increasing demand for safer and biodegradable alternatives for insect pest management.
Backx, Simon   +9 more
core   +2 more sources

Chronic digitalis therapy in patients before heart transplantation is an independent risk factor for increased posttransplant mortality

open access: yesTherapeutics and Clinical Risk Management, 2017
Rasmus Rivinius,1 Matthias Helmschrott,1 Arjang Ruhparwar,2 Ann-Kathrin Rahm,1,3 Fabrice F Darche,1 Dierk Thomas,1 Tom Bruckner,4 Philipp Ehlermann,1 Hugo A Katus,1 Andreas O Doesch1,5 1Department of Cardiology, Angiology and Pneumology, Heidelberg ...
Rivinius R   +9 more
doaj  

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