Results 121 to 130 of about 82,227 (164)

Contribution of Physical Interactions to Signaling Specificity between a Diguanylate Cyclase and Its Effector

mBio, 2015
Cyclic diguanylate (c-di-GMP) is a bacterial second messenger that controls multiple cellular processes. c-di-GMP networks have up to dozens of diguanylate cyclases (DGCs) that synthesize c-di-GMP along with many c-di-GMP-responsive target proteins that ...
Kurt M. Dahlstrom, Krista M. Giglio, Alan J. Collins, Holger Sondermann, George A. O’Toole   +4 more
doaj   +1 more source

Spatio-genetically coordinated TPR domain-containing proteins modulate c-di-GMP signaling in Vibrio vulnificus.

PLoS Pathogens
Vibrio species, which include several pathogens, are autochthonous to estuarine and warm coastal marine environments, where biofilm formation bolsters their ecological persistence and transmission.
Shobnom Mustaree, Ram Podicheti, Doug Rusch, Dean A Rowe-Magnus   +3 more
doaj   +1 more source

Oxygen-responsive KoBdcA/KoBdcB/KoBpdA system regulates c-di-GMP levels to control bacterial cellulose biosynthesis and motility in Kosakonia oryzendophytica FY-07

Microbiology Spectrum
Cyclic di-GMP (c-di-GMP) acts as a bacterial second messenger that regulates various physiological processes, including biofilm formation, motility, and virulence. It is synthesized by diguanylate cyclases (DGCs) and degraded by phosphodiesterases (PDEs),
Xueqing Zhao, Yucheng Shi, Wenzhuo Tian, Yutong Tian, Chuxiao Hu, Ziye Guo, Ting Ma, Guoqiang Li, Ge Gao   +8 more
doaj   +1 more source

STING-dependent recognition of cyclic di-AMP mediates type I interferon responses during Chlamydia trachomatis infection. [PDF]

, 2013
UnlabelledSTING (stimulator of interferon [IFN] genes) initiates type I IFN responses in mammalian cells through the detection of microbial nucleic acids. The membrane-bound obligate intracellular bacterium Chlamydia trachomatis induces a STING-dependent
Barker, Jeffrey R, Burdette, Dara L, Carpenter, Victoria K, Koestler, Benjamin J, Valdivia, Raphael H, Vance, Russell E, Waters, Christopher M   +6 more
core   +2 more sources

c-di-GMP phosphodiesterase ProE interacts with quorum sensing protein PqsE to promote pyocyanin production in Pseudomonas aeruginosa

mSphere
The universal bacterial second messenger bis-(3′-5′)-cyclic dimeric guanosine monophosphate (c-di-GMP) plays critical roles in regulating a variety of bacterial functions such as biofilm formation and virulence.
Qishun Feng, Xin Dai, Qiulan Wu, Lianhui Zhang, Liang Yang, Yang Fu   +5 more
doaj   +1 more source

More than Enzymes That Make or Break Cyclic Di-GMP—Local Signaling in the Interactome of GGDEF/EAL Domain Proteins of Escherichia coli

mBio, 2017
The bacterial second messenger bis-(3′-5′)-cyclic diguanosine monophosphate (c-di-GMP) ubiquitously promotes bacterial biofilm formation. Intracellular pools of c-di-GMP seem to be dynamically negotiated by diguanylate cyclases (DGCs, with GGDEF domains)
Olga Sarenko, Gisela Klauck, Franziska M. Wilke, Vanessa Pfiffer, Anja M. Richter, Susanne Herbst, Volkhard Kaever, Regine Hengge   +7 more
doaj   +1 more source

A general mechanism for initiating the bacterial general stress response

eLife
The General Stress Response promotes survival of bacteria in adverse conditions, but how sensor proteins transduce species-specific signals to initiate the response is not known. The serine/threonine phosphatase RsbU initiates the General Stress Response
Rishika Baral, Kristin Ho, Ramasamy P Kumar, Jesse B Hopkins, Maxwell B Watkins, Salvatore LaRussa, Suhaily Caban-Penix, Logan A Calderone, Niels Bradshaw   +8 more
doaj   +1 more source

A messenger molecule governs interdependency in an evolved Pseudomonas aeruginosa biofilm community [PDF]

, 2011
Biofilm populations are known to harbor great diversity, but the importance of this diversity is not fully understood. A likely contributor to this variation is the second messenger molecule cyclic-di-GMP: low levels associate with a planktonic lifestyle
Johnson, Thomas MacElliott
core   +1 more source

Role of c-di-GMP signalling in bacterial-host interactions [PDF]

, 2010
Bacteria have various ways to sense environmental signals and to adapt their behavior and physiology through different signaling systems. Secondary messenger signaling, amplified by enzymatic activity, rapidly transmits a signal in the cell, resulting in
Lamprokostopoulou, Agaristi
core  

Genetic dissection of cyclic di-GMP signaling in Pseudomonas aeruginosa via diguanylate cyclase disruption

bioRxiv
The second messenger bis-(3′→5′)-cyclic dimeric guanosine monophosphate (c-di-GMP) governs adaptive responses in the opportunistic pathogen Pseudomonas aeruginosa, including biofilm formation and the transition from acute to chronic infections ...
Román A. Martino, Daniel C. Volke, Albano H. Tenaglia, Paula M. Tribelli, P. Nikel, A. Smania   +5 more
semanticscholar   +1 more source