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Enzymatic synthesis of c-di-GMP using a thermophilic diguanylate cyclase
Analytical Biochemistry, 2009The cyclic dinucleotide c-di-GMP is a widespread bacterial messenger molecule with potential application as a therapeutic agent for treating bacterial infection. Current enzymatic synthesis of c-di-GMP using mesophilic diguanylate cyclase (DGC) proteins suffers from low production yield due to protein instability and strong product inhibition.
Feng, Rao +6 more
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ASSESSMENT OF A PREDICTED DIGUANYLATE CYCLASE IN TREPONEMA DENTICOLA
2018VCU Theses and ...
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Enzymatic Production of c-di-GMP Using a Thermophilic Diguanylate Cyclase
2017C-di-GMP has emerged as a prevalent bacterial messenger that controls a multitude of bacterial behaviors. Having access to milligram or gram quantities of c-di-GMP is essential for the biochemical and structural characterization of enzymes and effectors involved in c-di-GMP signaling.
Prabhadevi, Venkataramani +1 more
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Proceedings of the National Academy of Sciences of the United States of America, 2006
Alice N Neely +2 more
exaly
Alice N Neely +2 more
exaly

