Proteomic Biomarkers Are Linked to QTc Interval in Patients With Chronic Heart Failure
PROTEOMICS – Clinical Applications, Volume 20, Issue 1, January 2026.ABSTRACT Objective This study investigates the link between circulating proteins and rate‐corrected QT (QTc) interval in patients with heart failure with reduced ejection fraction (HFrEF) and their association with cardiovascular outcomes. Methods and Results We analyzed 197 HFrEF patients from the prospective Serial Biomarker Measurements and New ...
Mylène Barry‐Loncq de Jong +14 more
wiley +1 more source
New Insights on Sarcoplasmic Reticulum Calcium Regulation in Muscle Fatigue [PDF]
, 2011 A consistent observation with fatigue in skeletal muscle is a decline in the amplitude of the myoplasmic Ca2+ transient, which is thought to result primarily from a reduced Ca2+ flux through the ryanodine receptor (RyR1) of the sarcoplasmic reticulum (SR)
Fitts, Robert H.
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Dimethyl 4-(4-ethoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Acta Crystallographica Section E, 2009 In the title molecule, C19H23NO5, the dihedral angle formed by the benzene ring and the planar part of the dihydropyridine ring is 83.52 (5)°. The dihydropyridine ring adopts a flattened boat conformation. In the crystal, molecules are
Hoong-Kun Fun +4 more
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Pulmonary Circulation, Volume 16, Issue 1, January 2026.ABSTRACT Pulmonary hypertension (PH) causes progressive pulmonary vascular resistance and right heart failure. We investigated whether beta‐alanine (β‐Ala) improves right ventricular (RV) remodeling and dysfunction in a monocrotaline (MCT)‐induced PH rat model. Male Wistar rats were assigned to control, MCT‐PH, and β‐Ala‐treated PH groups.
Hongling Su +11 more
wiley +1 more source
Synthesis of dihydropyridine and piperidine derivatives via an unexpected reaction of pyridine with acetyl chloride [PDF]
, 2013 Acetyl chloride reacts with pyridine to give a mixture of N-acetyl-1,4- and 1,2-dihydropyridyl acetic acid (1a,b) after water quenching. The reactioninvolves the formation of a zwitterionic ketene enolate intermediate which results from deprotonation of
Mannu, Alberto +2 more
core
Opposite Effects of a Single IIIS5 Mutation on Phenylalkylamine and Dihydropyridine Interaction with L-type Ca2+ Channels [PDF]
, 2004 Irene Huber +5 more
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Clinical Otolaryngology, Volume 51, Issue 1, Page 17-24, January 2026.ABSTRACT Objective Identify and summarise the evidence on the efficacy of low‐dose verapamil use for adult patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP). Methods Two reviewers independently searched the data sources until the 28th of December 2023.
Fangxing Yin +3 more
wiley +1 more source
Perioperative Acute Hypertension – Role of Clevidipine Butyrate
Frontiers in Pharmacology, 2014 Lakshmi N Kurnutala +3 more
doaj +1 more source
Addressing unmet needs for chronic kidney disease treatment in type 1 diabetes: A review
Diabetes, Obesity and Metabolism, Volume 28, Issue 1, Page 16-26, January 2026.Abstract Chronic kidney disease (CKD) is a serious complication occurring in nearly one of three people with type 1 diabetes (T1D). Major therapeutic advances have been made in the management of CKD for people with type 2 diabetes (T2D), thereby improving their kidney, cardiovascular, and survival outcomes.
Katherine R. Tuttle +3 more
wiley +1 more source
High doses of lercanidipine are better tolerated than other dihydropyridines in hypertensive patients with metabolic syndrome: results from the TOLERANCE study [PDF]
, 2008 Vivencio Barrios +6 more
openalex +1 more source