Results 11 to 20 of about 4,456 (181)

Transdermal delivery of Diltiazem HCl from matrix film: Effect of penetration enhancers and study of antihypertensive activity in rabbit model [PDF]

Journal of Advanced Research, 2016
Rabinarayan Parhi
exaly   +2 more sources

The effect of pH and Polymer type on Release of Diltiazem HCl from hydrophilic matrices

Journal of Mazandaran University of Medical Sciences, 2007
Background and Purpose: Oral administrations have been used for many years as a main method comparing to other methods. Sustained release techniques have been a great interest recently.
J. Akbari, Ph.D.,  R. Enayati-fard, Ph.D, M. Saeedi, Ph.D., A. Aghpour, Pharm.D   +3 more
doaj   +1 more source

Anogenital Contact Dermatitis in Spain: A REIDAC Study of Patients Undergoing Patch Testing in 2019-2024. [PDF]

Contact Dermatitis
Allergic contact dermatitis is very common in patients with anogenital lesions referred for patch testing in Spain. Key allergens include fragrances, preservatives and topical treatments like anaesthetics and steroids. Emerging sensitisers including benzisothiazolinone and sodium metabisulphite are also relevant.
Grau-Pérez M, Mercader-García P, Giménez-Arnau AM, Sanz-Sánchez T, Ninet VZ, Guijarro SC, Miquel FJM, Salvador JFS, González-Pérez R, González IR, Baldrich ES, Carrascosa JM, de Frutos FJO, Serna MR, Ortega MEG, Suárez CP, Triviño FJN, Chicharro P, Andreu M, Gilo AS, Pereyra Rodríguez JJ, Nieto MAP, Melé-Ninot G, Guillén PS, de la Fuente EG, Elosua-González M, Munera-Campos M, Romero FT, Descalzo MÁ, Borrego L.   +29 more
europepmc   +2 more sources

Neuron-non-neuron electrical coupling networks are involved in chronic stress-induced electrophysiological changes in lateral habenular neurons. [PDF]

J Physiol
Abstract figure legend We investigated electrophysiological changes in lateral habenula (LHb) neurons induced by chronic social defeat stress in mice. LHb neurons exhibited short (<400 ms) rebound depolarizing potentials (short‐RDPs) or long‐RDPs (order of seconds) (long‐RDPs) after the offset of hyperpolarization. The incidence of long‐RDP neurons was
Yamaoka K, Nozaki K, Zhu M, Terai H, Kobayashi K, Ito H, Matsumata M, Takemoto H, Ikeda S, Sotomaru Y, Mori T, Aizawa H, Hashimoto K.   +12 more
europepmc   +2 more sources

Optimasi Hidroksipropil Metilselulosa dan Polivinil Pirolidon dalam Sediaan Mucoadhesive Buccal Film Diltiazem Hidroklorida [PDF]

, 2021
Diltiazem HCl is a class of benzodiazepine calcium channel blockers used to treat angina pectoris, arrhythmias, and hypertension. Diltiazem HCl improves first-pass metabolism, a short half time of 3-5 hours, and bioavailability of diltiazem for oral ...
Sari, Lusia Oktora Ruma Kumala, Sudianingsih, Septi, Wicaksono, Yudi   +2 more
core   +2 more sources

Aptamer-based cocaine assay using a nanohybrid composed of ZnS/Ag2Se quantum dots, graphene oxide and gold nanoparticles as a fluorescent probe [PDF]

, 2020
Authors report on a new fluoro-graphene-plasmonic nanohybrid aptamer-based fluorescent nanoprobe for cocaine. To construct the nanoprobe, newly synthesized glutathione-capped ZnS/Ag 2Se quantum dots (QDs) were first conjugated to graphene oxide (GO) to ...
Abdolvand, Amin, Adegoke, Oluwasesan, Nic Daeid, Niamh, Pereira-Barros, Magda A., Zolotovskaya, Svetlana   +4 more
core   +2 more sources

Thermodynamics of clay–drug complex dispersions: Isothermal titration calorimetry and high-performance liquid chromatography

Journal of Pharmaceutical Analysis, 2020
An understanding of the thermodynamics of the complexation process utilized in sustaining drug release in clay matrices is of great importance. Several characterisation techniques as well as isothermal calorimetry were utilized in investigating the ...
Ana-Maria Totea, Juan Sabin, Irina Dorin, Karl Hemming, Peter R. Laity, Barbara R. Conway, Laura Waters, Kofi Asare-Addo   +7 more
doaj   +1 more source

Development and release mechanism of diltiazem HCl prolonged release matrix tablets [PDF]

Drug Delivery, 2009
A coated matrix tablet formulation has been used to develop controlled release diltiazem HCl (DIL) tablets. The developed drug delivery system provided prolonged drug release rates over a defined period of time. DIL tablets prepared using dry mixing and direct compression and the core consisted of hydrophilic and hydrophobic polymers such as ...
Harikrishna, Boyapally, Ravi Kumar, Nukala, Dionysios, Douroumis   +2 more
openaire   +2 more sources

Design & Evaluation of Pulsatile Drug Delivery of Diltiazem Hcl

International Journal For Multidisciplinary Research, 2023
Oral controlled drug delivery systems represent the most popular form of controlled drug delivery systems for the obvious advantages of oral route of drug administration.
BHUKYA NAGARAJU -, M ANVESH RAJ -, Nagaraju B. -   +2 more
openaire   +1 more source

A Facile Protocol for C(sp²)-C(sp³) Bond Formation Reactions Toward Functionalized E3 Ligase Ligands. [PDF]

ChemMedChem
A robust C(sp2)–C(sp3) decarboxylative coupling strategy enables access to new CRBN ligands and degraders with improved physicochemical properties. This synthetic approach is expanding the chemical space beyond C(sp2)–N linkages, fine‐tuning proteolysis‐targeting chimera activities and unlocking previously inaccessible degrader chemotypes.
Maksutova A, Geiger TM, Cianni L, Pieńkowska DE, Gerhartz J, Read L, Bricelj A, Herrmann A, Nelles ML, Ng YLD, Hartmann MD, Krönke J, Sosič I, Nowak RP, Gütschow M, Steinebach C.   +15 more
europepmc   +2 more sources