Results 31 to 40 of about 4,456 (181)

The influence of fillers on theophylline release from clay matrices [PDF]

, 2015
: The objectives of this study were to investigate the suitability of magnesium aluminium silicate (MAS) (Veegum®) to control drug release of a model drug, theophylline, from tablet matrices.
Adebisi, Adeola O., Asare-Addo, Kofi, Conway, Barbara R.   +2 more
core   +1 more source

Some variables affecting the characteristics of Eudragit E-sodium alginate polyelectrolyte complex as a tablet matrix for diltiazem hydrochloride

Acta Pharmaceutica, 2014
Eudragit E (EE)-sodium alginate (SA) polyelectrolyte complexes (PECs) were prepared at pH 4 and 5.8 using sodium alginate of high (SAH) and low viscosity (SAL).
Yusif Rehab Mohammad, Hashim Irhan Ibrahim Abu, El-Dahan Marwa Salah   +2 more
doaj   +1 more source

Standard Protocols for Characterising Primary and In Vitro-Generated Human Hepatocytes. [PDF]

J Cell Mol Med
ABSTRACT Hepatocyte‐like cells (HLCs) derived from pluripotent stem cells (PSCs) or direct reprogramming are an unlimited source of human hepatocytes for biomedical applications. HLCs are used to model human diseases, develop precise drugs and establish groundbreaking regenerative cell‐based therapies.
Heydari Z, Gramignoli R, Piryaei A, Zahmatkesh E, Pooyan P, Seydi H, Nussler A, Szkolnicka D, Rashidi H, Najimi M, Hay DC, Vosough M.   +11 more
europepmc   +2 more sources

In vivo Assessment of Diltiazem HCl Immobilized Co-polymeric pH Sensitive Microgels

FRONTIERS IN CHEMICAL SCIENCES, 2023
Novel stimuli responsive coplymeric (2-ethyl hexyl acrylate -co- itaconic acid diltiazem HCl loaded microgels were fabricated and characterized successfully to reduce the degradation of drugs in acidic pH of stomach resulting in reduced bioavailability to minimize dosing frequency and enhance patient compliance.
Rabia Razzaq, null Fahmida Jabeen, null Zarmina Rashid, null Nazar Mohammad Ranjha   +3 more
openaire   +1 more source

Development and Validation of Novel Analytical Method for Estimation of Diltiazem HCL

International Journal Of Pharmaceutical And Bio-Medical Science, 2023
A novel, simple, accurate and precise Zero order derivative spectroscopic method was developed and validated for the estimation of Diltiazem HCl in bulk and Pharmaceutical dosage forms and has an absorption maximum at 193 nm in 0.05N Sulphuric acid. The Linearity was found to be in the concentration range of 3-18 μg/ml and the correlation coefficient ...
M, Pooja, Chaithra CN, Rajasekaran, S.
openaire   +1 more source

Comparative effectiveness of monotherapies and combination therapies for patients with hypertension: protocol for a systematic review with network meta-analyses [PDF]

, 2013
BACKGROUND: Hypertension has been cited as the most common attributable risk factor for death worldwide, and in Canada more than one of every five adults had this diagnosis in 2007.
Andrea Tricco, Brian Hutton, David Moher, Dean Fergusson, Edward Mills, Fatemeh Yazdi, Frans HH Leenen, Jennifer Tetzlaff, Justin Thielman, Kristian Thorlund, Lise Bjerre, Salmaan Kanji, Sharon Straus   +12 more
core   +1 more source

Development and evaluation of microporous osmotic tablets of diltiazem hydrochloride

Journal of Advanced Pharmaceutical Technology & Research, 2012
Microporous osmotic tablet of diltiazem hydrochloride was developed for colon targeting. These prepared microporous osmotic pump tablet did not require laser drilling to deliver the drug to the specific site of action.
Afifa Bathool, D V Gowda, Mohammed S Khan, Ayaz Ahmed, S L Vasudha, K Rohitash   +5 more
doaj   +1 more source

The association of the vanin-1 N131S variant with blood pressure is mediated by endoplasmic reticulum-associated degradation and loss of function [PDF]

, 2014
High blood pressure (BP) is the most common cardiovascular risk factor worldwide and a major contributor to heart disease and stroke. We previously discovered a BP-associated missense SNP (single nucleotide polymorphism)-rs2272996-in the gene encoding ...
Bandyopadhyay, Anupam, COGENT BP consortium,, Cooper, Richard S, Elston, Robert C, Feng, Tao, Franceschini, Nora, Gao, Jianmin, Mu, Ting-Wei, Sung, Yun Ju, Tang, Hua, Tayo, Bamidele O, Wang, Heming, Wang, Ya-Juan, Williams, Scott M, Zhu, Xiaofeng   +14 more
core   +7 more sources

Preparation of modified release diltiazem HCl capsule by complexation with ion exchange resin [PDF]

Iraqi Journal of Pharmacy, 2011
Background: Diltiazem HCl is a calcium channel blocker drug used in the treatment of angina pectoris and hypertension. Objective: To prepare a sustained release diltiazem HCl capsule by complexation with polystyrene sulfonate strong cation exchange resin (dowex®50wx4) as a complexing and retarding agent.
Eman B.H. Al-Khedairy, Alaa A. Abdulrasso, Jenan M. AL-Mosawi   +2 more
openaire   +2 more sources

Evaluation of the drug solubility and rush ageing on drug release performance of various model drugs from the modified release polyethylene oxide matrix tablets [PDF]

, 2017
Hydrophilic matrix systems are currently some of the most widely used drug delivery systems for controlled-release oral dosage forms. Amongst a variety of polymers, polyethylene oxide (PEO) is considered an important material used in pharmaceutical ...
A Miranda, AG Thombre, BJ Lee, CJ Kim, D Kiss, EM Yasser, H Lapidus, J Gaston, J Petrovi’c, K Cho, K Pielichowski, KA Khan, L Liu, L Maggie, L Yang, M Dimitrov, M Efentakis, M Rane, MA Khan, MA Longer, MM Crowley, MO Emeji, N Sarisuta, P Roy, PD Haan, PS Heng, S Engineer, S Shojaee, S Shojaee, SW Bigger, USP Pharmacopoeia 26, Y Malah   +31 more
core   +1 more source