Results 41 to 50 of about 4,501 (180)

Vegetable Oil‐Based Materials for Drug Delivery Systems and Wound Dressings

Macromolecular Bioscience, EarlyView.
Renewable resources like vegetable oils are increasingly explored for biomaterial production in biomedical applications. Their monoglycerides and triglycerides inherently possess functions or can be chemically modified to introduce functional groups suitable for polymerization, yielding biomaterials with desirable properties such as flexibility ...
Lucas M. Favre, Nicolas Masurier, Anne Aubert‐Pouëssel   +2 more
wiley   +1 more source

Antiplasmodial Activity and Pharmacokinetic Profiling of Cryptolepine and 2,7‐Dibromocryptolepine With a View to Informing the Design of Novel Antimalarial Cryptolepine Analogues

Drug Development Research, Volume 87, Issue 2, April 2026.
ABSTRACT The roots of the climbing shrub Cryptolepis sanguinolenta are traditionally used in West Africa for the treatment of malaria. The principal constituent, cryptolepine (1), has been shown to have antimalarial activity but there are concerns regarding its toxicity on account of its DNA‐intercalating property.
Elodie Chenu, James Duffy, Arnold Donkor Forkuo, Stephen Y. Gbedema, Seham Abdelall, Muhammad Wahajuddin, Huw S. Jones, Colin W. Wright   +7 more
wiley   +1 more source

Evaluation of the drug solubility and rush ageing on drug release performance of various model drugs from the modified release polyethylene oxide matrix tablets [PDF]

, 2017
Hydrophilic matrix systems are currently some of the most widely used drug delivery systems for controlled-release oral dosage forms. Amongst a variety of polymers, polyethylene oxide (PEO) is considered an important material used in pharmaceutical ...
A Miranda, AG Thombre, BJ Lee, CJ Kim, D Kiss, EM Yasser, H Lapidus, J Gaston, J Petrovi’c, K Cho, K Pielichowski, KA Khan, L Liu, L Maggie, L Yang, M Dimitrov, M Efentakis, M Rane, MA Khan, MA Longer, MM Crowley, MO Emeji, N Sarisuta, P Roy, PD Haan, PS Heng, S Engineer, S Shojaee, S Shojaee, SW Bigger, USP Pharmacopoeia 26, Y Malah   +31 more
core   +1 more source

Application of 4-chloro-7-nitrobenzofurazan for the analysis of propafenone and diltiazem hydrochlorides using kinetic spectrophotometric and spectrofluorimetric methods [PDF]

, 2013
Several simple, sensitive, accurate and inexpensive spectrophotometric and spectrofluorimetric methods were developed for the determination of propafenone HCl and diltiazem HCl using 4-chloro-7-nitrobenzofurazan (NBD-Cl) accompanied with kinetic study ...
Abdellatef, Hisham Ezzat, Ayad, Magda Mohamed, Hosny, Mervat Mohamed, Sharaf, Yassmin Ahmed   +3 more
core   +1 more source

Development and Validation of Quality by Design‐Based HPLC Method for Impurity Profiling of Alprazolam

SEPARATION SCIENCE PLUS, Volume 8, Issue 10, October 2025.
ABSTRACT A quality by design (QbD)‐aided stability‐indicating method was developed for the simultaneous quantification of alprazolam and its four impurities using HPLC. The method was systematically optimized, followed by the establishment of a “method operable design region (MODR).” Critical parameters and ICH (Q14) emphasize the adherence to a “low ...
Mahesh Napa, Venkata Ratnam K., Venkata Nadh Ratnakaram, Sunil Dhuri, Bondigalla Ramachandra   +4 more
wiley   +1 more source

Sex‐specific mechanisms of cerebral microvascular BKCa dysfunction in a mouse model of Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue 2, February 2025.
Abstract INTRODUCTION Cerebrovascular dysfunction occurs in Alzheimer's disease (AD), impairing hemodynamic regulation. Large conductance Ca2+‐activated K+ channels (BKCa) regulate cerebrovascular reactivity and are impaired in AD. BKCa activity depends on intracellular Ca2+ (Ca2+ sparks) and nitro‐oxidative post‐translational modifications.
Josiane F. Silva, Felipe D. Polk, Paige E. Martin, Stephenie H. Thai, Andrea Savu, Matthew Gonzales, Allison M. Kath, Michael T. Gee, Paulo W. Pires   +8 more
wiley   +1 more source

Identifikasi Potensi Interaksi Obat Pada Pasien Rawat Inap Penyakit Dalam Di RSUD Dr. Moewardi Tahun 2014 [PDF]

, 2016
Patients with internal diseases are usually treated by a combination of more than two drugs that causes potential drug interactions. Patients who suffer from the internal disease usually suffer from more than one disease.
, Dra. Nurul Mutmainah, M.Si., Apt, Widyaningrum, Ristia   +1 more
core  

Regulation of Cardiomyocyte Proliferation by microRNAs and Small Molecules [PDF]

, 2018
Understanding the molecular mechanisms regulating cardiac cell proliferation during the embryonic, fetal and adult life holds a paramount importance in view of developing innovative strategies aimed at inducing myocardial regeneration after cardiac ...
Torrini, Consuelo
core   +1 more source

Part 2: Drug Interactions Involving Cannabis Products in Persons Aged 18 and Over: A Summary of Published Case Reports and Analysis of the FDA Adverse Event Reporting System

Pharmacology Research &Perspectives, Volume 13, Issue 1, February 2025.
ABSTRACT The increasing utilization of cannabis products combined with lack of data regarding potential cannabis–prescription drug interactions is concerning. This study aimed to review published case reports and FDA Adverse Event Reporting System (FAERS) spontaneous reports to assess cannabis–drug interactions in persons aged 18 and over. A literature
Maryann R. Chapin, Sandra L. Kane‐Gill, Xiaotong Li, Kojo Abanyie, Sanya B. Taneja, Susan Egbert, Mary F. Paine, Richard D. Boyce   +7 more
wiley   +1 more source

Inhibition of diacylglycerol lipase α induced blood–brain barrier breach in female Sprague–Dawley rats

The Journal of Physiology, Volume 603, Issue 4, Page 929-947, 15 February 2025.
Abstract figure legend This study demonstrated that intraperitoneal administration of the diacylglycerol lipase α (DAGLα) inhibitor, LEI‐106, causes blood–brain barrier (BBB) disruption manifesting as increased [14C]sucrose uptake in in situ brain perfusion experiments.
Erika Liktor‐Busa, Aidan A. Levine, Sally J. Young, Colin Bader, Seph M. Palomino, Felipe D. Polk, Sarah A. Couture, Paulo W. Pires, Trent Anderson, Tally M. Largent‐Milnes   +9 more
wiley   +1 more source