Results 51 to 60 of about 1,271 (129)

Proteome-Wide Survey Reveals Norbornene Is Complementary to Dimedone and Related Nucleophilic Probes for Cysteine Sulfenic Acid [PDF]

, 2019
Detection of cysteine sulfenic acid in live cells is critical in advancing our understanding of cysteine redox chemistry and its biological function. Accordingly, there is a need to develop sulfenic acid-specific chemical probes with distinct reaction ...
Marc, Remke, Lisa, Alcock, Michael, Perkins, Gonçalo, Bernardes, Kai, Stühler, Maike, Langini, Justin, Chalker   +6 more
core   +1 more source

4a′-Hydroxy-3′,3′,5,6′,6′,7-hexamethyl-3′,4′,4a′,6′,7′,9a′-hexahydrospiro[indole-3,9′-xanthene]-1′,2,8′(1H,2′H,5′H)-trione

Molbank, 2023
Pseudo-multicomponent reactions (Pseudo-MCRs) have led to a variety of compounds with interesting biological properties, especially desirable in the pharmaceutical industry.
Yuliya E. Ryzhkova, Varvara M. Kalashnikova, Fedor V. Ryzhkov, Artem N. Fakhrutdinov, Michail N. Elinson   +4 more
doaj   +1 more source

β‐Triketone‐Based Ionizable Cationic Lipids Synthesized via Click Chemistry for siRNA Delivery

Advanced Science, Volume 13, Issue 26, 8 May 2026.
This study innovatively applies β‐triketone‐based click chemistry in the synthesis of ionizable cationic lipids (ICLs), which allows the generation of a lipid library in large quantities and in a short time. The ICLs identified achieved effective lipid nanoparticles‐mediated hepatic gene silencing in vivo using siRNA, and computational simulations are ...
Huatian Li, Haocheng Tang, Yiqing Mu, Shangyu Chen, Paul Edward Floreancig, Junmei Wang, Yixian Huang, Song Li   +7 more
wiley   +1 more source

Direct Mechanoorganocatalysis via Surface Functionalization of Milling Reactors With Amine Functions

ChemistryEurope, Volume 4, Issue 5, May 2026.
Surface functionalization of milling jars in epoxy resin furnished reactive milling jars, able to perform direct mechanoorganocatalysis with high efficiency, recyclability, and simplified purification. This proof of concept was applied successfully to base‐catalyzed Knoevenagel condensation and multicomponent reactions.
Joao Tanepau, Maxime Provost, Marie Gressier, Marie‐Joëlle Menu, Sandrine Duluard, Frédéric Lamaty, Julien Pinaud, Xavier Bantreil   +7 more
wiley   +1 more source

Synthesis of Polyhydroxylated Pyrrolidinyl Analogs of Sugar Nucleotides. Experimental and Computational Studies on Their Interactions With GalNAC‐T's

ChemBioChem, Volume 27, Issue 7, 14 April 2026.
A multidisciplinary approach based on organic synthesis supported by quantum mechanical calculations, efficient phosphorylation methods, affinity studies using conventional techniques and saturation transfer difference nuclear magnetic resonance, together with molecular dynamics simulations, has enabled the preparation of nucleotide analogs with ...
Pedro Merino, Veronica Juste, Alejandro Montesa, Sandra Pereira, Sara Orta, Manuel Pedrón, Ana I. Jiménez, Sonsoles Martín‐Santamaría, Ramón Hurtado‐Guerrero, Ignacio Delso, Tomás Tejero   +10 more
wiley   +1 more source

Structure and total synthesis of benzylthiocrellidone, a novel dimedone-based vinyl sulfide from the sponge Crella spinulata

, 1999
A concise synthesis of the yellow pigment benzylthiocrellidone 1, based on a Michael addition-elimination of dimedone 2 to the ketene thioacetal 7 derived from dimedone, benzyl bromide and carbon disulfide, is described.
Lam, Hon Wai, Cooke, Paul A., Pattenden, Gerald, Bandaranayake, Wickramasinghe M., Wickramasinghe, Wasantha A.   +4 more
core   +1 more source

Development of a Green Method for the Synthesis of Xanthene-1,8-dione Derivatives from Dimedone and Aldehydes

Engineering Proceedings
A green and efficient method was developed for the synthesis of 1,8-dioxo-octahydroxanthene derivatives using linear alkylbenzene sulfonic acid (LABSA) as an eco-friendly Brønsted acid catalyst under aqueous reflux conditions.
Imene Maallem, Malika Berredjem
doaj   +1 more source

Hexahydroquinoline Featuring Amide Functionality: A Promising Scaffold With Calcium Channel Blocking Activity

Drug Development Research, Volume 87, Issue 2, April 2026.
ABSTRACT Hexahydroquinoline (HHQ) is a widely recognized scaffold that has garnered considerable attention owing to its diverse pharmacological properties. The structure of HHQ includes a 1,4‐dihydropyridine (DHP) ring, which serves as the pharmacophore for the predominant class of drugs known as calcium channel blockers.
Ebru Koçak Aslan, Kevin Lam, Sun Huang, Göknil Pelin Coşkun, Ayşe Karagüzel, Katrin Denzinger, Kaan Birgül, Mert Ülgen, Jordan W. Nafie, Onur Şahin, Daniel W. Armstrong, Gerald W. Zamponi, Gerhard Wolber, Miyase Gözde Gündüz   +13 more
wiley   +1 more source

Rh(III)-catalyzed chelation-assisted C–H activation/annulation of 2-arylimidazolines with cyclic diazo-1,3-dicarbonyl compounds: a novel approach to tetracyclic annulated derivatives of 2,3-dihydroimidazo[2,1-a]isoquinoline

Beilstein Journal of Organic Chemistry
2-Arylimidazolines were annulated with cyclic diazo-1,3-dicarbonyl compounds under Rh(III)-catalysis for the first time. The developed general and efficient approach based on CH-activation allowed the efficient preparation of five novel types of ...
Ivan Lyutin, Grigory Kantin, Olga Bakulina, Dmitry Dar'in   +3 more
doaj   +1 more source

Synthesis of Heterocyclic Compounds Derived From Dimedone and Their Anti-tumor and Tyrosine Kinase Inhibitions

Acta Chimica Slovenica, 2020
The reaction of dimedone with arylaldehydes gave the benzylidene derivatives 3a–c, the latter underwent a series of heterocyclization reactions to give fused thiophene, pyrazole isoxazole and pyridazine derivatives.
Rafat Mohareb, Fatma Manhi, Amal Abdelwahab   +2 more
doaj   +1 more source