Results 111 to 120 of about 7,495 (248)

Recreational use of naturally occurring dimethyltryptamine – contributing to psychosis? [PDF]

Australian & New Zealand Journal of Psychiatry, 2012
Johanna M Warren, Pallavi Dham-Nayyar, and Jacob ...
Warren, J., Dham-Nayyar, P., Alexander, J.   +2 more
openaire   +3 more sources

Psychedelics as pharmacotherapeutics for substance use disorders: A scoping review on clinical trials and perspectives on underlying neurobiology

British Journal of Pharmacology, EarlyView.
Theorized mechanism of dopamine homeostasis restoration in the nucleus accumbens core induced by a psychedelic intervention. Abstract Psychedelics have garnered great attention in recent years as treatments for major depressive disorder (MDD) and treatment‐resistant depression because of their ability to alter consciousness and afflicted cognitive ...
Lucas Wittenkeller, Gary Gudelsky, T. John Winhusen, Davide Amato   +3 more
wiley   +1 more source

Exploring Endogenous Tryptamines: Overlooked Agents Against Fibrosis in Chronic Disease? A Narrative Review

Livers
Long regarded as illicit substances with no clinical value, N-dimethylated tryptamines—such as N,N-dimethyltryptamine, 5-methoxy-N,N-dimethyltryptamine, and bufotenine—have been found to produce naturally in a wide variety of species, including humans ...
Hunter W. Korsmo
doaj   +1 more source

N,N-DIMETHYLTRYPTAMINE, A NATURAL HALLUCINOGEN, AMELIORATES ALZHEIMER’ S DISEASE BY RESTORING NEURONAL SIGMA-1 RECEPTOR- MEDIATED ENDOPLASMIC RETICULUM-MITOCHONDRIA CROSSTALK [PDF]

Int J Neuropsychopharmacol
Background Aberrant neuronal Sigma-1 receptor (Sig-1r)-mediated endoplasmic reticulum (ER)- mitochondria signaling plays a key role in the neuronal cytopathology of Alzheimer’s disease (AD).
Dan Cheng, Zhuo Lei, K. Chu, Oi Jin Honey Lam, C. Chiang, Zhang-Jin Zhang   +5 more
europepmc   +2 more sources

Integrating the Mystical Experience Questionnaire Into a Broader Psychometric Framework: English Validation of the Psychedelic Experience Scale and Comparison of Psilocybin and LSD Sessions Across Two Controlled Settings

International Journal of Methods in Psychiatric Research, Volume 35, Issue 2, June 2026.
ABSTRACT Objectives For English, the validated part of Psychedelic Experience Scale (PES48) is a four‐factor structure called the Mystical Experience Questionnaire (MEQ30). The other validated part of the PES48 consists of four more factors: two more mystical factors (paradoxicality and connectedness, which together with the MEQ30 form the MEQ40), and ...
Kurt Stocker, Matthias Hartmann, Frederick S. Barrett, William A. Richards, Nathan D. Sepeda, Laura Ley, Anna M. Becker, Friederike Holze, Matthias E. Liechti   +8 more
wiley   +1 more source

A Fully Validated LC-MS Quantitation Method for Psychoactive Compounds Found in Native South American Plant Species

Psychoactives
Psychoactive drugs are compounds that alter the function of the central nervous system, resulting in changes in perception, mood, cognition, and behavior.
Jonathan Tran, Aaron C. Elkins, Simone Vassiliadis, Noel O. I. Cogan, Simone J. Rochfort   +4 more
doaj   +1 more source

DMT alters cortical travelling waves

eLife, 2020
Psychedelic drugs are potent modulators of conscious states and therefore powerful tools for investigating their neurobiology. N,N, Dimethyltryptamine (DMT) can rapidly induce an extremely immersive state of consciousness characterized by vivid and ...
Andrea Alamia, Christopher Timmermann, David J Nutt, Rufin VanRullen, Robin L Carhart-Harris   +4 more
doaj   +1 more source

Hemorheological and metabolic consequences of renal ischemia-reperfusion and their modulation by N,N-dimethyltryptamine on a rat model [PDF]

, 2018
K
Bidiga, László, Deák, Ádám, Frecska, Ede, Ghanem, Souleiman, Magyar, Zsuzsanna, Mester, Anita, Nemes, Balázs Áron, Németh, Norbert, Pető, Katalin, Somogyi, Viktória, Tánczos, Bence   +10 more
core   +1 more source

Towards Mechanism‐Informed Treatments for Mental Health

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Neuropsychiatric disorders impose a major global health burden, and current treatments, which historically mostly targeted dopamine and serotonin dysfunctions, often provide only partial, symptomatic relief. This review highlights emerging evidence that additional neuromodulator systems, including acetylcholine, norepinephrine, and endocannabinoids ...
Iker Bengoetxea de Tena, Farhanah Nabilah Sallie, Arvie Rodriguez Abiero, Beatrice Rizzi, Leandro Gabriel Champarini, Elisa Corti, Gianluca Masella, Ariel L. Dunn, Luisa Bandeira Binder, Tyler J. Wenzel, Agustin I. Robles, Roberta G. Anversa, Cécilia Tremblay, Aliance Romain Fokoua, Randriely Merscher Sobreira de Lima, Mateus D'Ávila, Trang T. T. Truong, Jessica C. Pierce, Rui S. Rodrigues, Luis Dinamarca‐Villarroel, Felipe Borges Almeida, Aino‐Kaisa Piironen, Andrey F. L. Aguiar, Andrés M. Jaramillo, Lucas Santos, Anja de Lange, David J. Nutt, Andrew J. Lawrence   +27 more
wiley   +1 more source

A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms

Psychopharmacology, 2019
5-methoxy-N,N-dimethyltryptamine (hereinafter referred to as 5-MeO-DMT) is a psychedelic substance found in the secretion from the parotoid glands of the Bufo alvarius toad.
M. V. Uthaug, R. Lancelotta, K. Oorsouw, K. Kuypers, N. Mason, J. Rak, A. Šuláková, Radek Jurok, M. Maryška, M. Kuchař, T. Páleníček, J. Riba, J. Ramaekers   +12 more
semanticscholar   +1 more source