Results 101 to 110 of about 3,335 (217)

Continuous flow synthesis of N,N-dimethyltryptamine (DMT) analogues with therapeutic potential

Herein, we describe the continuous flow synthesis and in-line extraction of N,N-dimethyltryptamine (DMT) and several of its analogues using a Fischer indole reaction, along with a larger gram scale synthesis (4.75 g) of the model compound. These products
Stevens, Christian, Vandevelde, Marthe, Stevens, Christian V., Simoens, Andreas, Dejaegere, Andreas   +4 more
core   +1 more source

Short term changes in the proteome of human cerebral organoids induced by 5-methoxy-N,N-dimethyltryptamine

, 2017
Dimethyltryptamines are hallucinogenic serotonin-like molecules present in traditional Amerindian medicine (e.g.Ayahuasca)recently associated with cognitive gains, antidepressant effects and changes in brain areas related to attention.
Juliana Minardi Nascimento, Daniel Martins-de-Souza, Renata de Moraes Maciel, Draulio B. de Araujo, Rafaela Costa Sartore, Sidarta Ribeiro, Stevens Rehen, Vanja Dakic   +7 more
core   +1 more source

Best practices for first psychedelic experiences: harm reduction advice from the psychedelic community

Harm Reduction Journal
Background The use of psychedelics is currently increasing in the United States. Awareness of clinical trials investigating the therapeutic applications of psychedelics may result in a record number of people who use psychedelics for the first-time. This
Daniel J. Kruger, Gina Mersereau, Ashley Sullivan, Julie Barron, Moss Herberholz, Niloufar Pouyan, Jacob S. Aday, Kevin F. Boehnke   +7 more
doaj   +1 more source

An ontogenic study of the behavioral effects of chronic intermittent exposure to ayahuasca in mice

Brazilian Journal of Medical and Biological Research
Ayahuasca is a beverage obtained from decoctions of the Banisteriopsis caapi plus Psychotria viridis. In religious contexts, ayahuasca is used by different age groups.
N.F. Correa-Netto, M.Y. Masukawa, F. Nishide, G.S. Galfano, F. Tamura, M.K. Shimizo, M.P. Marcato, J.G. Santos Junior, A. Linardi   +8 more
doaj   +1 more source

Human psychopharmacology of N,N-dimethyltryptamine

, 1996
We generated dose-response data for the endogenous and ultra-short-acting hallucinogen, N,N-dimethyltryptamine (DMT), in a cohort of experienced hallucinogen users, measuring multiple biological and psychological outcome measures.
Strassman, Rick J
core  

Why N,N-dimethyltryptamine matters: unique features and therapeutic potential beyond classical psychedelics

Frontiers in Psychiatry
Graphical ...
Cristiano Chaves, Rafael G. dos Santos, Rafael G. dos Santos, Serdar M. Dursun, Serdar M. Dursun, Massimo Tusconi, Mauro Giovanni Carta, Elisa Brietzke, Jaime E. C. Hallak, Jaime E. C. Hallak, Jaime E. C. Hallak   +10 more
doaj   +1 more source

An encounter with death: a comparative thematic and content analysis of naturalistic DMT experiences and the near-death experience

Frontiers in Psychology
IntroductionClassical near-death experiences (NDEs) refer to states of disconnected consciousness characterised by a range of features occurring in the context of being close to death. Various psychedelic substances, such as N,N-dimethyltryptamine (DMT),
Pascal Michael, David Luke, David Luke, Oliver Robinson   +3 more
doaj   +1 more source

Dose response and time course effects off N,N-dimethyltryptamine on dissruption of rat shuttlebox avoidance

, 1977
N,N-Dimethyltryptamine (DMT) was given (ip) in different doses (0.25, 0.5, 1.0, 2.0, 4.0, 8.0 mg/kg) in a randomized order to a group of ten rats (Fisher 344/Mai) who were trained to a high, stable base line of conditioned avoidance responding in the ...
E.A. Moja, R. J. Wyatt, J. C. Gillin, D. M. Stoff   +3 more
core  

Complete biosynthesis of psychedelic tryptamines from three kingdoms in plants. [PDF]

Sci Adv
Berman P, Höfer J, Mehlman H, Almekias-Siegl E, Khersonsky O, Dong Y, Heinig U, Sulimani L, Hao LK, Cohen S, Peleg Y, Meir S, Rogachev I, Meiri D, Fleishman SJ, Aharoni A.   +15 more
europepmc   +1 more source

Reaction of N,N‑Dimethyltryptamine with Dichloromethane Under Common Experimental Conditions

ACS Omega, 2018
Lee E. Dunlap, David E. Olson
doaj   +1 more source