Results 41 to 50 of about 3,335 (217)

Antidepressive and anxiolytic effects of ayahuasca: a systematic literature review of animal and human studies

Brazilian Journal of Psychiatry, 2016
Objective: To conduct a systematic literature review of animal and human studies reporting anxiolytic or antidepressive effects of ayahuasca or some of its isolated alkaloids (dimethyltryptamine, harmine, tetrahydroharmine, and harmaline).
Rafael G. dos Santos, Flávia L. Osório, José Alexandre S. Crippa, Jaime E. C. Hallak   +3 more
doaj   +1 more source

Quantum chemical study of the hydrolysis of oxidized endogenous psychedelic N,N-dimethyltryptamine [PDF]

, 2022
The metabolism of biogenic N,N-dimethyltryptamine (DMT) starts with its enzymatic oxidation to indole-3-N,N-dimethylethaniminium cation (imDMT(+)) by monoamine oxidase (MAO).
Kubicsko, Karoly, Kovacs, Richard D., Farkas, Odon   +2 more
core   +1 more source

1H Nuclear Magnetic Resonance: A Future Approach to the Metabolic Profiling of Psychedelics in Human Biofluids?

Frontiers in Psychiatry, 2021
While psychedelics may have therapeutic potential for treating mental health disorders such as depression, further research is needed to better understand their biological effects and mechanisms of action when considering the development of future novel ...
Sylvana Vilca-Melendez, Malin V. Uthaug, Malin V. Uthaug, Julian L. Griffin   +3 more
doaj   +1 more source

In silico study of dimethyltryptamine analogues against 5-HT1B receptor: Molecular docking, dynamic simulations and ADMET prediction [PDF]

Journal of HerbMed Pharmacology, 2022
Introduction: The 5-HT1B receptor has a potential role in various psychiatric disorders such as depression, anxiety, and post-traumatic stress disorder.
Neyder Contreras, Antistio Alvíz-Amador, Isabella Manzur-Villalobos   +2 more
doaj   +1 more source

Influence of environmental factors and cultural methods on the content of N,N-Dimethyltryptamine in Psychotria viridis (Rubiaceae).

, 2018
Psychotria viridis is one of the species that produces N,N-dimethyltryptamine. Its decoction together with other species, such as Banisteriopsis caapi, produces ayahuasca, a beverage used for ritualistic and medicinal purposes.
Bearzoti, Eduardo, Cardoso, Gabriele de Azevedo, Vieira Filho, Sidney Augusto, Cavalcanti, André Dias, Okuma, Adriana Akemi, Duarte, Lucienir Pains, Oliveira, Fernando Luiz Pereira de   +6 more
core   +2 more sources

Concise Synthesis of -Dimethyltryptamine and 5-Methoxy--dimethyltryptamine Starting with Bufotenine from Brazilian ssp

Natural Product Communications, 2015
Bufotenine ( 1 , 5-hydroxy- N,N -dimethyltryptamine) was isolated from seeds of Anadenanthera spp., a tree widespread in the Brazilian cerrado, using an efficient acid-base shakeout protocol. The conversion of bufotenine into N,N -dimethyltryptamine ( 4 )
Leandro A. Moreira, Maria M. Murta, Claudia C. Gatto, Christopher W. Fagg, Maria L. dos Santos   +4 more
doaj   +1 more source

Targeting INMT and interrupting its methylation pathway for the treatment of castration resistant prostate cancer

Journal of Experimental & Clinical Cancer Research, 2021
Background Castration-resistant prostate cancer (CRPC) is associated with a very poor prognosis, and the treatment of which remains a serious clinical challenge.
Shangwei Zhong, Ji-Hak Jeong, Changhao Huang, Xueyan Chen, Shohreh Iravani Dickinson, Jasreman Dhillon, Li Yang, Jun-Li Luo   +7 more
doaj   +1 more source

sj-docx-1-jop-10.1177_02698811221104054 – Supplemental material for Significance of mammalian N, N-dimethyltryptamine (DMT): A 60-year-old debate

, 2022
Supplemental material, sj-docx-1-jop-10.1177_02698811221104054 for Significance of mammalian N, N-dimethyltryptamine (DMT): A 60-year-old debate by Javier Hidalgo Jiménez and José Carlos Bouso in Journal of ...
Javier Hidalgo Jiménez (12876833), José Carlos Bouso (10680081)   +1 more
core   +1 more source

Rumors of Psychedelics, Psychotropics and Related Derivatives in Vachellia and Senegalia in Contrast with Verified Records in Australian Acacia

Plants, 2022
There are almost 1000 species of Acacia sensu stricto in Australia, while the 44 species and 4 subspecies in southern Africa were taxonomically revised in the year 2011 to Senegalia and Vachellia.
Nicholas J. Sadgrove
doaj   +1 more source

Behavioral effects of 5-methoxy-N:N-dimethyltryptamine, other tryptamines, and LSD

, 1962
The effect of 5-methoxy-N:N-dimethyltryptamine on the conditioned avoidance response of trained rats was compared quantitatively, using a shuttle-box, with that of several substituted tryptamines and LSD-25.
Peter K. Gessner, Irvine H. Page
core   +1 more source