Results 31 to 40 of about 5,561 (207)
LC/MS/MS analysis of the endogenous dimethyltryptamine hallucinogens, their precursors, and major metabolites in rat pineal gland microdialysate [PDF]
, 2013 We report a qualitative liquid chromatography–tandem mass spectrometry (LC/MS/MS) method for the simultaneous analysis of the three known N , N ‐dimethyltryptamine endogenous hallucinogens, their precursors and metabolites, as well as melatonin and its ...
Barker, Steven A. +3 more
core +1 more source
Pharmacokinetics of N,N-dimethyltryptamine in Humans
European Journal of Drug Metabolism and Pharmacokinetics, 2023 N,N-dimethyltryptamine (DMT) is a psychedelic compound under development for the treatment of major depressive disorder (MDD). This study evaluated the preclinical and clinical pharmacokinetics and metabolism of DMT in healthy subjects.The physiochemical properties of DMT were determined using a series of in vitro experiments and its metabolic profile ...
Meghan Good +11 more
openaire +2 more sources
Frontiers in Psychiatry, 2021 While psychedelics may have therapeutic potential for treating mental health disorders such as depression, further research is needed to better understand their biological effects and mechanisms of action when considering the development of future novel ...
Sylvana Vilca-Melendez +3 more
doaj +1 more source
In silico study of dimethyltryptamine analogues against 5-HT1B receptor: Molecular docking, dynamic simulations and ADMET prediction [PDF]
Journal of HerbMed Pharmacology, 2022 Introduction: The 5-HT1B receptor has a potential role in various psychiatric disorders such as depression, anxiety, and post-traumatic stress disorder.
Neyder Contreras +2 more
doaj +1 more source
Natural Product Communications, 2015 Bufotenine ( 1 , 5-hydroxy- N,N -dimethyltryptamine) was isolated from seeds of Anadenanthera spp., a tree widespread in the Brazilian cerrado, using an efficient acid-base shakeout protocol. The conversion of bufotenine into N,N -dimethyltryptamine ( 4 )
Leandro A. Moreira +4 more
doaj +1 more source
Journal of Experimental & Clinical Cancer Research, 2021 Background Castration-resistant prostate cancer (CRPC) is associated with a very poor prognosis, and the treatment of which remains a serious clinical challenge.
Shangwei Zhong +7 more
doaj +1 more source
Plants, 2022 There are almost 1000 species of Acacia sensu stricto in Australia, while the 44 species and 4 subspecies in southern Africa were taxonomically revised in the year 2011 to Senegalia and Vachellia.
Nicholas J. Sadgrove
doaj +1 more source
Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens [PDF]
, 2016 The present study investigated interactions between the novel psychoactive tryptamines DiPT, 4-OH-DiPT, 4-OH-MET, 5-MeO-AMT, and 5-MeO-MiPT at monoamine receptors and transporters compared with the classic hallucinogens lysergic acid diethylamide (LSD ...
Hoener, Marius C. +3 more
core +1 more source
Frontiers in PsychiatryBackgroundDue to their potential impact on mood and wellbeing there has been increasing interest in the potential of serotonergic psychedelics such as N,N-dimethyltryptamine (DMT) in the treatment of major depressive disorder (MDD).AimThe aim of Part A ...
Ellen James +14 more
doaj +1 more source
The pharmacological interaction of compounds in ayahuasca: a systematic review [PDF]
Brazilian Journal of Psychiatry, 2020 Ayahuasca is a South American psychoactive plant brew used as traditional medicine in spiritual and in cultural rituals. This is a review of the current understanding about the pharmacological mechanisms that may be interacting in ayahuasca.
Simon Ruffell +4 more
doaj +1 more source