Results 31 to 40 of about 3,892 (211)

Proliferative Effects of the Psychedelic N,N-Dimethyltryptamine (DMT) in Human Neural Stem Cells. [PDF]

ACS Chem Neurosci
The serotonergic psychedelic N,N-dimethyltryptamine (DMT) produces rapid antidepressant effects in preclinical and early clinical studies. Therapeutic benefits have been linked to sustained neural plasticity, including adult neurogenesis in rodents ...
Salerno JA, Dominguez ER, Karmirian K, Arrais BABMS, Alves J, Erjautz G, Kroening K, Souza LRQ, Ornelas I, Rehen S.   +9 more
europepmc   +2 more sources

Antidepressive and anxiolytic effects of ayahuasca: a systematic literature review of animal and human studies

Brazilian Journal of Psychiatry, 2016
Objective: To conduct a systematic literature review of animal and human studies reporting anxiolytic or antidepressive effects of ayahuasca or some of its isolated alkaloids (dimethyltryptamine, harmine, tetrahydroharmine, and harmaline).
Rafael G. dos Santos, Flávia L. Osório, José Alexandre S. Crippa, Jaime E. C. Hallak   +3 more
doaj   +1 more source

Discovery and In Vitro Characterization of SPL028: Deuterated N,N‑Dimethyltryptamine

, 2023
The psychedelic N,N- dimethyltryptamine (DMT) is in clinical development for the treatment of major depressive disorder. However, when administered via intravenous infusion, its effects are short-lived due to rapid clearance.
Zelah Joel (16912794), Marie Layzell (16912785), Peter Rands, Carol Routledge, Carol Routledge (3023037), Ellen James (12499174), Meghan Good, Rick Cousins (5932172), Ellen James, Peter Rands (16912788), Rick Cousins, Tiffanie Benway (16912797), Zelah Joel, Meghan Good (16912791), Tiffanie Benway, Marie Layzell   +15 more
core   +2 more sources

1H Nuclear Magnetic Resonance: A Future Approach to the Metabolic Profiling of Psychedelics in Human Biofluids?

Frontiers in Psychiatry, 2021
While psychedelics may have therapeutic potential for treating mental health disorders such as depression, further research is needed to better understand their biological effects and mechanisms of action when considering the development of future novel ...
Sylvana Vilca-Melendez, Malin V. Uthaug, Malin V. Uthaug, Julian L. Griffin   +3 more
doaj   +1 more source

Methanol extract and N,N-dimethyltryptamine from psychotria viridis ruiz & pav. inhibit in vitro the Zika virus infection.

, 2021
Zika virus (ZIKV) is a public health problem due to its association with serious fetal and neurological complications and the lack of antiviral agents and licensed vaccines against this virus.
Nizer, Waleska Stephanie da Cruz, Magalhães, Cíntia Lopes de Brito, Tótola, Antônio Helvécio, Ferraz, Ariane Coelho, Moraes, Thaís de Fátima Silva, Vieira Filho, Sidney Augusto, Magalhães, José Carlos de, Soares, Débora Barbosa da Silva, Duarte, Lucienir Pains   +8 more
core   +1 more source

Influence of environmental factors and cultural methods on the content of N,N-Dimethyltryptamine in Psychotria viridis (Rubiaceae).

, 2018
Psychotria viridis is one of the species that produces N,N-dimethyltryptamine. Its decoction together with other species, such as Banisteriopsis caapi, produces ayahuasca, a beverage used for ritualistic and medicinal purposes.
Bearzoti, Eduardo, Cardoso, Gabriele de Azevedo, Vieira Filho, Sidney Augusto, Cavalcanti, André Dias, Okuma, Adriana Akemi, Duarte, Lucienir Pains, Oliveira, Fernando Luiz Pereira de   +6 more
core   +3 more sources

In silico study of dimethyltryptamine analogues against 5-HT1B receptor: Molecular docking, dynamic simulations and ADMET prediction [PDF]

Journal of HerbMed Pharmacology, 2022
Introduction: The 5-HT1B receptor has a potential role in various psychiatric disorders such as depression, anxiety, and post-traumatic stress disorder.
Neyder Contreras, Antistio Alvíz-Amador, Isabella Manzur-Villalobos   +2 more
doaj   +1 more source

Concise Synthesis of -Dimethyltryptamine and 5-Methoxy--dimethyltryptamine Starting with Bufotenine from Brazilian ssp

Natural Product Communications, 2015
Bufotenine ( 1 , 5-hydroxy- N,N -dimethyltryptamine) was isolated from seeds of Anadenanthera spp., a tree widespread in the Brazilian cerrado, using an efficient acid-base shakeout protocol. The conversion of bufotenine into N,N -dimethyltryptamine ( 4 )
Leandro A. Moreira, Maria M. Murta, Claudia C. Gatto, Christopher W. Fagg, Maria L. dos Santos   +4 more
doaj   +1 more source

-dimethyltryptamine Concentration in Ritualistic Ayahuasca Users [PDF]

, 2023
Consumption of the psychedelic brew ayahuasca is a central ritualistic aspect of the Santo Daime religion. The current observational, baseline controlled study was designed to assess whether members (n = 24) of the Santo Daime church would show enhanced ...
Toennes, Stefan, Reckweg, Johannes, Ramaekers, Jan, Mallaroni, Pablo, Lilian Kloft, Stefan W. Toennes, van Oorsouw, Kim, Johannes G. Ramaekers, Pablo Mallaroni, Johannes T. Reckweg, Natasha L. Mason, Kim van Oorsouw, Kloft, Lilian, Mason, Natasha   +13 more
core   +1 more source

Targeting INMT and interrupting its methylation pathway for the treatment of castration resistant prostate cancer

Journal of Experimental & Clinical Cancer Research, 2021
Background Castration-resistant prostate cancer (CRPC) is associated with a very poor prognosis, and the treatment of which remains a serious clinical challenge.
Shangwei Zhong, Ji-Hak Jeong, Changhao Huang, Xueyan Chen, Shohreh Iravani Dickinson, Jasreman Dhillon, Li Yang, Jun-Li Luo   +7 more
doaj   +1 more source