Results 31 to 40 of about 3,335 (217)

Pharmacokinetics of N,N-dimethyltryptamine in Humans

European Journal of Drug Metabolism and Pharmacokinetics, 2023
N,N-dimethyltryptamine (DMT) is a psychedelic compound under development for the treatment of major depressive disorder (MDD). This study evaluated the preclinical and clinical pharmacokinetics and metabolism of DMT in healthy subjects.The physiochemical properties of DMT were determined using a series of in vitro experiments and its metabolic profile ...
Meghan Good, Zelah Joel, Tiffanie Benway, Carol Routledge, Chris Timmermann, David Erritzoe, Richard Weaver, Graham Allen, Charlotte Hughes, Helen Topping, Amy Bowman, Ellen James   +11 more
openaire   +2 more sources

The endogenous hallucinogen and trace amine N,N-dimethyltryptamine (DMT) displays potent protective effects against hypoxia via sigma-1 receptor activation in human primary iPSC-derived cortical neurons and microglia-like immune cells

Frontiers in Neuroscience, 2016
N,N-dimethyltryptamine (DMT) is a potent endogenous hallucinogen present in the brain of humans and other mammals. Despite extensive research, its physiological role remains largely unknown.
Attila Szabo, Attila Szabo, Attila Szabo, Attila Kovacs, Jordi Riba, Jordi Riba, Srdjan Djurovic, Srdjan Djurovic, Eva Rajnavolgyi, Ede Frecska   +9 more
doaj   +1 more source

Effects of N,N-dimethyltryptamine on electrically evoked responses in the cat visual system and modification by neuroleptic agents, [PDF]

, 1976
The effects of N,N-dimethyltryptamine on electrically evoked potentials in the visual system of the cat and the interaction of selected neuroleptic agents with dimethyltryptamine were studied.
Moore, R. H., Hatada, K., Domino, Edward F.   +2 more
core   +1 more source

The therapeutic potentials of ayahuasca: possible effects against various diseases of civilization

Frontiers in Pharmacology, 2016
Ayahuasca is an Amazonian psychoactive brew of two main components. Its active agents are β-carboline and tryptamine derivatives. As a sacrament, ayahuasca is still a central element of many healing ceremonies in the Amazon Basin and its ritual ...
Ede eFrecska, Petra eBokor, Michael eWinkelman   +2 more
doaj   +1 more source

Discovery and In Vitro Characterization of SPL028: Deuterated N,N‑Dimethyltryptamine

, 2023
The psychedelic N,N- dimethyltryptamine (DMT) is in clinical development for the treatment of major depressive disorder. However, when administered via intravenous infusion, its effects are short-lived due to rapid clearance.
Zelah Joel (16912794), Marie Layzell (16912785), Peter Rands, Carol Routledge, Carol Routledge (3023037), Ellen James (12499174), Meghan Good, Rick Cousins (5932172), Ellen James, Peter Rands (16912788), Rick Cousins, Tiffanie Benway (16912797), Zelah Joel, Meghan Good (16912791), Tiffanie Benway, Marie Layzell   +15 more
core   +2 more sources

Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report

Brazilian Journal of Psychiatry, 2015
Objectives: Ayahuasca (AYA), a natural psychedelic brew prepared from Amazonian plants and rich in dimethyltryptamine (DMT) and harmine, causes effects of subjective well-being and may therefore have antidepressant actions.
Flávia de L. Osório, Rafael F. Sanches, Ligia R. Macedo, Rafael G. dos Santos, João P. Maia-de-Oliveira, Lauro Wichert-Ana, Draulio B. de Araujo, Jordi Riba, José A. Crippa, Jaime E. Hallak   +9 more
doaj   +1 more source

Psychedelics: A new era of treatment?

European Psychiatry, 2021
Introduction Psychedelics - including LSD (lysergic acid diethylamide), psilocybin, DMT (N, N-dimethyltryptamine), ayahuasca and mescaline - have an ancient history across various civilizations.
S. Torres
doaj   +1 more source

A Review of Aeruginascin and Potential Entourage Effect in Hallucinogenic Mushrooms

European Psychiatry, 2022
Introduction The 5-HT2A agonist classic psychedelic, psilocybin (O-phosphoryl-4-hydroxy-N,N-dimethyltryptamine) is a tryptophan, indole-based alkaloid present in up to 2% of certain hallucinogenic “magic” mushroom species; typically Psilocybe azurescens,
P. Chue, A. Andreiev, E. Bucuci, C. Els, J. Chue   +4 more
doaj   +1 more source

Methanol extract and N,N-dimethyltryptamine from psychotria viridis ruiz & pav. inhibit in vitro the Zika virus infection.

, 2021
Zika virus (ZIKV) is a public health problem due to its association with serious fetal and neurological complications and the lack of antiviral agents and licensed vaccines against this virus.
Nizer, Waleska Stephanie da Cruz, Magalhães, Cíntia Lopes de Brito, Tótola, Antônio Helvécio, Ferraz, Ariane Coelho, Moraes, Thaís de Fátima Silva, Vieira Filho, Sidney Augusto, Magalhães, José Carlos de, Soares, Débora Barbosa da Silva, Duarte, Lucienir Pains   +8 more
core   +1 more source

-dimethyltryptamine Concentration in Ritualistic Ayahuasca Users [PDF]

, 2023
Consumption of the psychedelic brew ayahuasca is a central ritualistic aspect of the Santo Daime religion. The current observational, baseline controlled study was designed to assess whether members (n = 24) of the Santo Daime church would show enhanced ...
Toennes, Stefan, Reckweg, Johannes, Ramaekers, Jan, Mallaroni, Pablo, Lilian Kloft, Stefan W. Toennes, van Oorsouw, Kim, Johannes G. Ramaekers, Pablo Mallaroni, Johannes T. Reckweg, Natasha L. Mason, Kim van Oorsouw, Kloft, Lilian, Mason, Natasha   +13 more
core   +1 more source