Results 11 to 20 of about 2,551 (177)

An Encounter With the Other: A Thematic and Content Analysis of DMT Experiences From a Naturalistic Field Study

open access: yesFrontiers in Psychology, 2021
Introduction:N,N-dimethyltryptamine (DMT) is an endogenous serotonergic psychedelic capable of producing radical shifts in conscious experience. Increasing trends in its use, as well as new trials administering DMT to patients, indicate the growing ...
Pascal Michael   +3 more
doaj   +1 more source

Infoveillance and Critical Analysis of the Systematically Reviewed Literature on Dimethyltryptamine and the “God Molecule”

open access: yesPharmaceuticals, 2023
Aboriginals of Latin America have used DMT (N,N-dimethyltryptamine) in ritualistic ceremonies for centuries. Nevertheless, there are limited data on web users’ interest concerning DMT.
Ahmed Al-Imam   +4 more
doaj   +1 more source

Neuropharmacology of N,N-dimethyltryptamine [PDF]

open access: yesBrain Research Bulletin, 2016
N,N-dimethyltryptamine (DMT) is an indole alkaloid widely found in plants and animals. It is best known for producing brief and intense psychedelic effects when ingested. Increasing evidence suggests that endogenous DMT plays important roles for a number of processes in the periphery and central nervous system, and may act as a neurotransmitter.
Theresa M, Carbonaro, Michael B, Gatch
openaire   +2 more sources

In Vitro Study of the Bioavailability and Bioaccessibility of the Main Compounds Present in Ayahuasca Beverages

open access: yesMolecules, 2021
Ayahuasca is a psychoactive beverage that contains the psychoactive compound N,N-dimethyltryptamine and β-carboline alkaloids. This study aims at determining in vitro the bioavailability and bioaccessibility of the main compounds present in decoctions of
Joana Gonçalves   +7 more
doaj   +1 more source

Novel Psychoactive Substances—Recent Progress on Neuropharmacological Mechanisms of Action for Selected Drugs

open access: yesFrontiers in Psychiatry, 2017
A feature of human culture is that we can learn to consume chemical compounds, derived from natural plants or synthetic fabrication, for their psychoactive effects.
Zurina Hassan   +8 more
doaj   +1 more source

A Model for the Application of Target-Controlled Intravenous Infusion for a Prolonged Immersive DMT Psychedelic Experience

open access: yesFrontiers in Pharmacology, 2016
The state of consciousness induced by N,N-dimethyltryptamine (DMT) is one of the most extraordinary of any naturally-occurring psychedelic substance.
Andrew Robert Gallimore, Rick Strassman
doaj   +1 more source

Pharmacokinetics of N,N-dimethyltryptamine in Humans

open access: yesEuropean Journal of Drug Metabolism and Pharmacokinetics, 2023
N,N-dimethyltryptamine (DMT) is a psychedelic compound under development for the treatment of major depressive disorder (MDD). This study evaluated the preclinical and clinical pharmacokinetics and metabolism of DMT in healthy subjects.The physiochemical properties of DMT were determined using a series of in vitro experiments and its metabolic profile ...
Meghan Good   +11 more
openaire   +2 more sources

Acute Intoxication following Dimethyltryptamine Ingestion [PDF]

open access: yesCase Reports in Emergency Medicine, 2018
Ayahuasca is a hallucinogenic tea that is most commonly comprised of the vine Banisteriopsis caapi alone or in combination with other plants such as Psychotria viridis. This concoction results in an orally active form of dimethyltryptamine (DMT), a hallucinogenic amine.
Matthew H. Bilhimer   +5 more
openaire   +3 more sources

The endogenous hallucinogen and trace amine N,N-dimethyltryptamine (DMT) displays potent protective effects against hypoxia via sigma-1 receptor activation in human primary iPSC-derived cortical neurons and microglia-like immune cells

open access: yesFrontiers in Neuroscience, 2016
N,N-dimethyltryptamine (DMT) is a potent endogenous hallucinogen present in the brain of humans and other mammals. Despite extensive research, its physiological role remains largely unknown.
Attila Szabo   +9 more
doaj   +1 more source

The therapeutic potentials of ayahuasca: possible effects against various diseases of civilization

open access: yesFrontiers in Pharmacology, 2016
Ayahuasca is an Amazonian psychoactive brew of two main components. Its active agents are β-carboline and tryptamine derivatives. As a sacrament, ayahuasca is still a central element of many healing ceremonies in the Amazon Basin and its ritual ...
Ede eFrecska   +2 more
doaj   +1 more source

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