Transient destabilization of whole brain dynamics induced by N,N-Dimethyltryptamine (DMT) [PDF]
Communications BiologyThe transition towards the brain state induced by psychedelic drugs is frequently neglected in favor of a static description of their acute effects. We use a time-dependent whole-brain model to reproduce large-scale brain dynamics measured with fMRI from
Juan Ignacio Piccinini +8 more
doaj +3 more sources
Pharmaceuticals, 2023 Aboriginals of Latin America have used DMT (N,N-dimethyltryptamine) in ritualistic ceremonies for centuries. Nevertheless, there are limited data on web users’ interest concerning DMT.
Ahmed Al-Imam +4 more
doaj +2 more sources
Acute Intoxication following Dimethyltryptamine Ingestion [PDF]
Case Reports in Emergency Medicine, 2018 Ayahuasca is a hallucinogenic tea that is most commonly comprised of the vine Banisteriopsis caapi alone or in combination with other plants such as Psychotria viridis. This concoction results in an orally active form of dimethyltryptamine (DMT), a hallucinogenic amine.
Matthew H. Bilhimer +5 more
core +4 more sources
Registered Clinical Trials of Ayahuasca and DMT: A Scoping Review. [PDF]
Clin Pharmacol TherInterest in ayahuasca and its main component, N,N‐Dimethyltryptamine (DMT), has currently moved from historical and experimental use into modern clinical development. Yet, current evidence is fragmented, and systematic mapping of trial methods and design choices remains limited.
Stojanović T +4 more
europepmc +2 more sources
Structural Pharmacology of Bufotenine Derivatives in Activating the 5-HT1A Receptor for Therapeutic Potential in Depression and Anxiety [PDF]
ResearchThe 5-HT1A receptor is a critical target in the treatment of depression and anxiety. Bufotenine derivatives, such as 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), 5-hydroxy-N,N-dimethyltryptamine (5-OH-DMT), and 5-hydroxy-N,N,N-dimethyltryptamine—derived
Shu-jie Li +16 more
doaj +2 more sources
Computational evaluation of aluminum and zinc doped C20 fullerenes as advanced sensors for the detection of the narcotic dimethyltryptamine [PDF]
Scientific ReportsN, N-Dimethyltryptamine (N, N-DMT) is a potent psychedelic substance whose detection is crucial in medical and forensic contexts. In this study, we computationally evaluate the potential of aluminum- and zinc-doped C20 fullerenes (AlC19 and ZnC19) as ...
Saad M. Alshahrani
doaj +2 more sources
Dimethyltryptamine: Endogenous Role and Therapeutic Potential [PDF]
Journal of Psychoactive Drugs, 2019 N, N-dimethyltryptamine (DMT) is an indole alkaloid produced by a number of plants and animals, including humans. Its psychoactive effects were first described in 1956 by Stephen Szára, but have been exploited for centuries by South American indigenous populations in the form of ayahuasca. In the present review, we assess the state of the art regarding
Alexandra Vsl, Rodrigues +2 more
exaly +3 more sources
N,N‐dimethyltryptamine and Amazonian ayahuasca plant medicine [PDF]
Human Psychopharmacology: Clinical and Experimental, 2022 AbstractObjectiveReports have indicated possible uses of ayahuasca for the treatment of conditions including depression, addictions, post‐traumatic stress disorder, anxiety and specific psychoneuroendocrine immune system pathologies. The article assesses potential ayahuasca and N,N‐dimethyltryptamine (DMT) integration with contemporary healthcare.
Edward James +3 more
openaire +5 more sources
Ayahuasca and Its Main Component N,N-Dimethyltryptamine (DMT) for the Treatment of Mental Disorders: Mechanisms of Action, Clinical Studies, and Tools to Explore the Human Mind [PDF]
BiomedicinesIn recent years, psychopharmacology has experienced a significant challenge, highlighting a renewed and strong scientific interest in psychedelics as breakthrough therapies for mental disorders.
Alice Melani +9 more
doaj +2 more sources
Dimethyltryptamine: hallucinogenic alkaloid on the Central Nervous System
Acta Brasiliensis, 2018 Hallucinogenic plants are widely used in rituals and religious cults. Ayahuasca tea and wine black Jurema, both hallucinogenic beverages, present the alkaloid dimethyltryptamine (DMT) responsible for the hallucinogenic effect due to interaction with ...
Darliane Freire Almeida +2 more
doaj +3 more sources