Results 21 to 30 of about 3,335 (217)

Lysergic Acid Diethylamide, Psilocybin and Dimethyltryptamine in Depression Treatment: A Systematic Review

open access: yesPharmaceuticals, 2021
Despite many different kinds of substances available for depression treatment, depression itself still appears to be a clinical challenge. Recently, formerly illicit substances came to scientists’ attention, including lysergic acid diethylamide (LSD ...
Gniewko Więckiewicz   +4 more
doaj   +2 more sources

Inhaled N, N-dimethyltryptamine diminishes connectivity between the ventral tegmental area and the nucleus accumbens: relevance to pathologies of mesolimbic and mesocortical pathways [PDF]

open access: yesScientific Reports
Reward processing is a broad psychological construct that can be parsed into distinct components known as “reinforcement learning” (learning), “reward responsiveness” (liking), and “motivation to obtain a reward” (wanting).
Gisela Lima   +6 more
doaj   +2 more sources

N,N-Dimethyltryptamine

open access: yes, 2020
A mystery that has been going on for centuries. The N,N-dimethyltryptamine (DMT) molecule, which is found in every living thing, especially in humans at the time of birth and death, and which some claim to open the door of the parallel universes, is a very harmful hallucinogen for some.
openaire   +2 more sources

N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role and Function [PDF]

open access: yesFrontiers in Neuroscience, 2018
This report provides a historical overview of research concerning the endogenous hallucinogen N, N-dimethyltryptamine (DMT), focusing on data regarding its biosynthesis and metabolism in the brain and peripheral tissues, methods and results for DMT ...
Steven A. Barker
doaj   +2 more sources

Effects of Ayahuasca on Personality: Results of Two Randomized, Placebo-Controlled Trials in Healthy Volunteers

open access: yesFrontiers in Psychiatry, 2021
Rationale: Previous studies with the serotonergic hallucinogens LSD and psilocybin showed that these drugs induced changes in personality traits, such as increases in Openness.
Juliana Mendes Rocha   +17 more
doaj   +1 more source

An Encounter With the Other: A Thematic and Content Analysis of DMT Experiences From a Naturalistic Field Study

open access: yesFrontiers in Psychology, 2021
Introduction:N,N-dimethyltryptamine (DMT) is an endogenous serotonergic psychedelic capable of producing radical shifts in conscious experience. Increasing trends in its use, as well as new trials administering DMT to patients, indicate the growing ...
Pascal Michael   +3 more
doaj   +1 more source

Neuropharmacology of N,N-dimethyltryptamine [PDF]

open access: yesBrain Research Bulletin, 2016
N,N-dimethyltryptamine (DMT) is an indole alkaloid widely found in plants and animals. It is best known for producing brief and intense psychedelic effects when ingested. Increasing evidence suggests that endogenous DMT plays important roles for a number of processes in the periphery and central nervous system, and may act as a neurotransmitter.
Theresa M, Carbonaro, Michael B, Gatch
openaire   +2 more sources

In Vitro Study of the Bioavailability and Bioaccessibility of the Main Compounds Present in Ayahuasca Beverages

open access: yesMolecules, 2021
Ayahuasca is a psychoactive beverage that contains the psychoactive compound N,N-dimethyltryptamine and β-carboline alkaloids. This study aims at determining in vitro the bioavailability and bioaccessibility of the main compounds present in decoctions of
Joana Gonçalves   +7 more
doaj   +1 more source

Novel Psychoactive Substances—Recent Progress on Neuropharmacological Mechanisms of Action for Selected Drugs

open access: yesFrontiers in Psychiatry, 2017
A feature of human culture is that we can learn to consume chemical compounds, derived from natural plants or synthetic fabrication, for their psychoactive effects.
Zurina Hassan   +8 more
doaj   +1 more source

A Model for the Application of Target-Controlled Intravenous Infusion for a Prolonged Immersive DMT Psychedelic Experience

open access: yesFrontiers in Pharmacology, 2016
The state of consciousness induced by N,N-dimethyltryptamine (DMT) is one of the most extraordinary of any naturally-occurring psychedelic substance.
Andrew Robert Gallimore, Rick Strassman
doaj   +1 more source

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