Results 121 to 130 of about 2,828 (161)
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Diosmetin Induces Apoptosis of Acute Myeloid Leukemia Cells
Molecular Pharmaceutics, 2018Acute myeloid leukemia is an aggressive disease with limited and nonselective therapeutic options. This study explored the bioactivity and cell death inducing mechanism of diosmetin, a novel compound identified in a nutraceutical screen to impart selective anti-AML activity.
Paul Spagnuolo
exaly +3 more sources
Mechanism underlying the vasodilation induced by diosmetin in porcine coronary artery
European Journal of Pharmacology, 2020Diosmetin is a flavonoid present naturally in citrus fruit. Plants containing diosmetin have been reported to have anti-hypertensive and vasorelaxant effects. Therefore, experiments were carried out to study the effects of diosmetin in segments of the porcine coronary artery (PCA).
Abdul Jabbar Shāh +2 more
exaly +3 more sources
Journal of Agricultural and Food Chemistry, 2012
The binding mechanism of molecular interaction between diosmetin and human serum albumin (HSA) in a pH 7.4 phosphate buffer was studied using atomic force microscopy (AFM) and various spectroscopic techniques including fluorescence, resonance light scattering (RLS), UV-vis absorption, circular dichroism (CD), and Fourier transform infrared (FT-IR ...
Guowen Zhang, Junhui Pan
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The binding mechanism of molecular interaction between diosmetin and human serum albumin (HSA) in a pH 7.4 phosphate buffer was studied using atomic force microscopy (AFM) and various spectroscopic techniques including fluorescence, resonance light scattering (RLS), UV-vis absorption, circular dichroism (CD), and Fourier transform infrared (FT-IR ...
Guowen Zhang, Junhui Pan
exaly +3 more sources
Phytotherapy Research
AbstractDiosmetin, a natural occurring flavonoid, is primarily found in citrus fruits, beans, and other plants. Diosmetin demonstrates a variety of pharmacological activities, including anticancer, antioxidant, anti‐inflammatory, antibacterial, metabolic regulation, cardiovascular function improvement, estrogenic effects, and others.
Li Xiaofang, Zihao Sun
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AbstractDiosmetin, a natural occurring flavonoid, is primarily found in citrus fruits, beans, and other plants. Diosmetin demonstrates a variety of pharmacological activities, including anticancer, antioxidant, anti‐inflammatory, antibacterial, metabolic regulation, cardiovascular function improvement, estrogenic effects, and others.
Li Xiaofang, Zihao Sun
exaly +3 more sources
Bioactivation of the phytoestrogen diosmetin by CYP1 cytochromes P450
Cancer Letters, 2009Breast cancer is a major cause of death worldwide. Amongst the various forms of treatment chemoprevention is favoured and natural products such as the dietary flavonoids have been examined for their cancer preventative activity. In this study we investigated the anticancer activity of the flavonoid diosmetin, as a result of cytochrome P450 CYP1 ...
Androutsopoulos, Vasilis +3 more
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Pharmacokinetic studies of diosmin and diosmetin in perfused rat liver
Xenobiotica, 19931. The kinetics and metabolism of diosmin and diosmetin were investigated in the isolated perfused rat liver in order to assess the role of the liver. 2. Diosmetin and especially diosmin disappeared quickly from the perfusion medium. 3. Both flavonoids were rapidly metabolized and diosmetin was partly excreted in bile as the glucuronide and sulphate ...
R, Perego +4 more
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Diosmetin inhibits the expression of alpha-hemolysin in Staphylococcus aureus
Antonie van Leeuwenhoek, 2015Staphylococcus aureus is a significant human pathogen that causes a wide range of diseases. Alpha-hemolysin (Hla), a pore-forming cytotoxin that is produced by most S. aureus strains, can cause tissue injury and plays a critical role in the virulence of this pathogen.
Liu, Shui +8 more
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Journal of Food Biochemistry, 2020
The interaction between adipocytes and macrophages in obese tissues plays a critical role in the onset of metabolic syndromes. This study aimed to evaluate the modulatory effect of diosmetin on anti-inflammatory and anti-lipolytic activities in the coculture of macrophages and adipocytes. The secretion of inflammatory mediators increased in a coculture
Hana Lee +4 more
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The interaction between adipocytes and macrophages in obese tissues plays a critical role in the onset of metabolic syndromes. This study aimed to evaluate the modulatory effect of diosmetin on anti-inflammatory and anti-lipolytic activities in the coculture of macrophages and adipocytes. The secretion of inflammatory mediators increased in a coculture
Hana Lee +4 more
openaire +2 more sources
In vivo and in vitro glucuronidation of the flavonoid diosmetin in rats.
Drug Metabolism and Disposition, 1993Flavonoids form an important family of compounds widely present in plants and therefore in food, sometimes as substitutes for synthetic antioxidants. Although the excretion routes of flavonoids in animals has been explored, little is known about the details of their conjugation in the xenobiotic metabolism pathway.
J A, Boutin +6 more
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Vietnam Journal of Chemistry
AbstractThe Diosmetin Phytosome (Dt‐Ph) was developed to enhance the complex's aqueous solubility and in vitro drug release compared to pure Diosmetin (Dt). The process variables such as the reactants’ molar ratio, reaction time, stirring speed, and reaction temperature were varied to identify the most appropriate conditions for synthesis.
Thi‐Kim‐Chi Huynh +11 more
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AbstractThe Diosmetin Phytosome (Dt‐Ph) was developed to enhance the complex's aqueous solubility and in vitro drug release compared to pure Diosmetin (Dt). The process variables such as the reactants’ molar ratio, reaction time, stirring speed, and reaction temperature were varied to identify the most appropriate conditions for synthesis.
Thi‐Kim‐Chi Huynh +11 more
openaire +1 more source